M-CSA Mechanism and Catalytic Site Atlas

Hyaluronate lyase (M-CSA:439)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1c82

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1egu(A), 1f9g(A), 1ojp(A), 1w3y(A), 2brp(A), 2brv(X), 2brw(A, B)

PDB sequences homologous to 1c82

Reference PDB chains/ identical chains	Homologous PDB chains	His399(232)A Tyr408(241)A Asn349(182)A Arg462(295)A
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1n7o(A)	His230 Tyr239 Asn180 Arg293
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	His232 Tyr241 Asn182 Arg295
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1n7n(A)	His230 Tyr239 Asn180 Arg293
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1hmw(A) 1hm2(A) 1hm3(A) 1hmu(A)	His225 Tyr234 Asn175 Arg288
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1loh(A) 1lxk(A)	His230 Phe239 Asn180 Arg293
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1f1s(A) 1lxm(A) 1i8q(A)	His309 Tyr318 Asn259 Arg372
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1n7r(A)	His230 Tyr239 Asn180 Arg293
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	2e24(A)	His221 Tyr230 Asn169 Arg284
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1x1i(A) 1x1j(A) 1x1h(A)	His221 Tyr230 Ala169 Arg284
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1ojo(A)	His232 Phe241 Asn182 Arg295
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1cb8(A)	His203 Tyr212 Asn153 Arg266
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	2x03(B,A)	His244 Ala253 Asn194 Arg307
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1j0m(A) 1j0n(A)	His221 Tyr230 Asn169 Arg284
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1rwa(A) 1rwf(A) 1rwc(A) 1rwg(A) 1rwh(A)	His233 Tyr242 Asn183 Arg296
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1n7p(A)	His230 Tyr239 Asn180 Arg293
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1ojm(A)	His230 Tyr239 Asn180 Arg293
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	2wco(A) 2wda(A)	His244 Tyr253 Asn194 Arg307
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	2e22(A)	His221 Tyr230 Asn169 Arg284
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1rw9(A)	His233 Tyr242 Asn183 Arg296
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1n7q(A)	His230 Tyr239 Asn180 Arg293
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	1ojn(A)	His232 Phe241 Asn182 Arg295
1c82(A) 1ojp(A) 1egu(A) 2brp(A) 2brw(B,A) 2brv(X) 1w3y(A) 1f9g(A)	6f2p(A)	x x x x