M-CSA Mechanism and Catalytic Site Atlas

Brefeldin A esterase (M-CSA:453)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of O68884

Reference Sequence	Homologue	Ser202 Asp308 His338 Tyr233 Tyr238 Gly127 (main-N) Gly128 (main-N)
O68884	O68884	Ser202 Asp308 His338 Tyr233 Tyr238 Gly127 Gly128
O68884	P16386	Ser424 Asp692 His722 not aligned not aligned Gly352 Gly353
O68884	P15304	Ser723 Asp1003 His1033 not aligned not aligned Gly651 Gly652
O68884	Q9US38	Ser181 Asp283 His313 not aligned not aligned Gly109 Gly110
O68884	P54310	Ser423 Asp694 His724 not aligned not aligned Gly351 Gly352
O68884	Q05469	Ser725 Asp994 His1024 not aligned not aligned Gly653 Gly654
O68884	P9WK87	Ser162 Asp260 His290 not aligned not aligned Gly90 Gly91
O68884	Q68J42	Ser424 Asp691 His721 not aligned not aligned Gly352 Gly353
O68884	Q5UQ83	Ser185 Asp282 His312 not aligned not aligned Ala113 Gly114
O68884	Q9R101	Ser424 Asp692 His722 not aligned not aligned Gly352 Gly353
O68884	Q0ZPV7	Ser169 Asp276 His306 Gly203 Lys208 Gly92 Gly93
O68884	B5BLW5	Ser156 Asp251 His281 not aligned not aligned Gly84 Ala85
O68884	P24484	Ser239 Asp361 His391 not aligned not aligned Gly167 Gly168
O68884	P9WK86	Ser162 Asp260 His290 not aligned not aligned Gly90 Gly91