M-CSA Mechanism and Catalytic Site Atlas

Chitinase (GH18, Class II) (M-CSA:478)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences homologous to 1ctn

Reference PDB chains/ identical chains	Homologous PDB chains	Tyr390(367)A Asp313(290)A Asp311(288)A Glu315(292)A
1ctn(A)	2g8z(A) 1zbk(A) 2g41(A) 2dsu(A) 1zl1(A) 2dsv(A) 2dsw(A) 1sr0(A) 2dpe(A) 2fdm(A)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	1hjv(C,B,A,D) 1nws(C,B,A,D) 1nwu(C,B,A,D) 1nwt(C,B,A,D) 1nwr(C,B,A,D) 1hjw(B,A) 1hjx(C,B,A,D)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	3g6m(A) 3g6l(A)	Tyr222 Asp152 Asp150 Glu154
1ctn(A)	3alf(A)	Tyr184 Asp114 Asp112 Glu116
1ctn(A)	5gzt(B)	Tyr970 Asp893 Asp891 Glu895
1ctn(A)	4uri(B,A)	Tyr185 Asp114 Asp112 Glu116
1ctn(A)	1guv(A)	Tyr191 Asp117 Asp115 Glu119
1ctn(A)	4ptm(A)	Tyr205 Asp134 Asp132 Glu136
1ctn(A)	4lgx(A)	Tyr208 Asp137 Asp135 Glu139
1ctn(A)	1ctn(A)	x x x x
1ctn(A)	2wk2(A)	Tyr367 Asp290 Asp288 Glu292
1ctn(A)	1itx(A)	Tyr247 Asp170 Asp168 Glu172
1ctn(A)	4txg(A)	Tyr397 Asp312 Asp310 Glu314
1ctn(A)	3wqw(A) 3wqv(A) 3wl1(A)	Tyr199 Asp128 Asp126 Glu130
1ctn(A)	3b9d(A) 3b9e(A) 3b9a(A)	Tyr370 Asp292 Asp290 Met294
1ctn(A)	1wb0(A) 1waw(A)	Tyr191 Asp117 Asp115 Glu119
1ctn(A)	3rme(B,A) 3fy1(B,A) 3rm9(B,A) 3fxy(C,B,A,D) 3rm4(B,A) 3rm8(B,A)	Tyr191 Asp117 Asp115 Glu119
1ctn(A)	4ay1(C,E,G,F,D,L,I,A,H,J,B,K)	Phe187 Ser118 Asp116 Ile120
1ctn(A)	4mpk(A) 4q7n(A) 4nsb(A) 4mtv(A) 4mav(A) 1tfv(A) 2o9o(A) 4ml4(A) 2qf8(A)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	3arz(A) 3arq(A) 3arv(A) 3arp(A) 3b8s(B,A) 3aro(A) 3arw(A) 3arr(A) 3ary(A) 3arx(A)	Tyr370 Asp292 Asp290 Glu294
1ctn(A)	3wl0(A)	Tyr199 Asp128 Asp126 Ala130
1ctn(A)	2ybu(E,C,F,D,A,B) 2ybt(C,E,F,D,A,B)	Tyr195 Asp121 Asp119 Glu123
1ctn(A)	4nzc(A) 4q22(A)	Tyr205 Asp134 Asp132 Glu136
1ctn(A)	1wno(B,A)	x x x x
1ctn(A)	4w5u(B,A)	Tyr250 Asp181 Asp179 Glu183
1ctn(A)	1x6l(A) 1x6n(A) 1rd6(A)	Tyr390 Asp313 Asp311 Glu315
1ctn(A)	3wij(A)	Tyr192 Asp118 Asp116 Gln120
1ctn(A)	1ll6(C,B,A,D)	Tyr204 Asn134 Asp132 Glu136
1ctn(A)	5wus(A) 5wvh(A)	x x x x
1ctn(A)	2dt3(A) 2o92(A) 2dt0(A) 1zu8(A) 2dsz(A) 1zbv(A) 2aos(A) 1zbw(A) 2b31(A) 2dt1(A) 2olh(A) 2dt2(A)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	5y2a(B,A)	x x x x
1ctn(A)	1e15(B,A) 1ur8(B,A) 1e6r(B,A) 1gpf(B,A) 1o6i(B,A) 1w1y(B,A) 1w1t(B,A) 1w1v(B,A) 1w1p(B,A)	Tyr214 Asp142 Asp140 Glu144
1ctn(A)	1lg2(A) 1lq0(A) 1lg1(A) 6ze8(C,E,F,D,A,B)	Tyr191 Asp117 Asp115 Glu119
1ctn(A)	4z2i(A) 3wd0(A) 4z2j(A) 4z2k(A) 3wd4(A) 3wd3(A) 3wd1(A) 3wd2(A) 4z2h(A) 4z2l(A) 4z2g(A)	Tyr218 Asp146 Asp144 Glu148
1ctn(A)	2esc(A)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	3qok(A)	Tyr225 Asp154 Asp152 Glu156
1ctn(A)	3wkz(A)	Tyr199 Asp128 Asp126 Gln130
1ctn(A)	5y2c(B,A)	x x x x
1ctn(A)	4wkf(A) 4wjx(A) 4wka(A) 4wkh(A) 4wk9(A) 5nr8(A) 5nra(A) 5nrf(A)	Tyr191 Asp117 Asp115 Glu119
1ctn(A)	1hki(A) 1hkj(A) 1hkm(A)	Tyr191 Asp117 Asp115 Glu119
1ctn(A)	1ffr(A)	Phe367 Asp290 Asp288 Glu292
1ctn(A)	4dws(C,B,A,D)	Tyr337 Asp260 Asp258 Glu262
1ctn(A)	1xhg(A) 1zbc(A) 1xrv(A) 1zb5(A)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	1e6z(B,A)	Tyr213 Asp141 Asp139 Glu143
1ctn(A)	1hkk(A)	Tyr191 Asp117 Asp115 Glu119
1ctn(A)	1ur9(B,A)	Tyr214 Asn142 Asp140 Glu144
1ctn(A)	1ffq(A) 1edq(A)	Tyr367 Asp290 Asp288 Glu292
1ctn(A)	1e9l(A) 1vf8(A)	Tyr191 Asp117 Asn115 Gln119
1ctn(A)	1e6p(B,A) 1e6n(B,A)	Tyr214 Asp142 Asp140 Gln144
1ctn(A)	1ll7(B,A)	Tyr204 Asp134 Asp132 Gln136
1ctn(A)	5wup(A) 5wv9(A)	x x x x
1ctn(A)	5wvf(A) 5wvg(A)	x x x x
1ctn(A)	1owq(A)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	5wv8(A) 5wvb(A)	x x x x
1ctn(A)	4p8w(A) 4p8v(A) 4p8x(A) 4p8u(A)	Phe193 Ser124 Asp122 Ile126
1ctn(A)	5y2b(A) 5y29(A)	x x x x
1ctn(A)	5gqb(A) 5gpr(A) 6jmn(A)	Tyr383 Asp306 Asp304 Glu308
1ctn(A)	5hbf(B,A)	Tyr212 Asp138 Asp136 Glu140
1ctn(A)	1eib(A)	Tyr367 Ala290 Asp288 Glu292
1ctn(A)	1goi(B,A)	Tyr214 Asp142 Asn140 Glu144
1ctn(A)	1syt(A)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	1nh6(A)	Tyr367 Asp290 Asp288 Leu292
1ctn(A)	1ehn(A)	Tyr367 Asp290 Asp288 Gln292
1ctn(A)	4mnk(A) 4mnj(A) 4r5e(A)	Tyr192 Asp118 Asp116 Glu120
1ctn(A)	1jne(A) 1jnd(A)	Phe222 Ala130 Asp128 Gln132
1ctn(A)	1kfw(A)	Tyr262 Asp181 Asp179 Glu183
1ctn(A)	1ljy(A)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	1ogg(B,A) 1ogb(B,A)	Tyr214 Asn142 Asp140 Glu144
1ctn(A)	2wm0(A) 2wly(A) 2wlz(A)	Tyr367 Asp290 Asp288 Glu292
1ctn(A)	1ll4(C,B,A,D) 1d2k(A)	Tyr204 Asp134 Asp132 Glu136
1ctn(A)	4a5q(C,E,D,A,B)	Tyr329 Asp258 Asp256 Glu260
1ctn(A)	3oa5(B,A)	x x x x
1ctn(A)	1h0i(B,A) 1h0g(B,A)	Tyr214 Asp142 Asp140 Glu144
1ctn(A)	5gzu(B,A) 5gzv(B,A)	Tyr719 Asp642 Asp640 Glu644
1ctn(A)	4s06(A)	Thr184 Ala117 Asp115 Leu119
1ctn(A)	1w9u(B,A) 1w9p(B,A) 3ch9(B,A) 2a3e(B,A) 2a3b(B,A) 3che(B,A) 2a3a(B,A) 3chc(B,A) 3chd(B,A) 2iuz(B,A) 1w9v(B,A) 2a3c(B,A) 3chf(B,A)	Tyr245 Asp175 Asp173 Glu177
1ctn(A)	1k9t(A)	Tyr367 Asp290 Asp288 Glu292
1ctn(A)	5df0(B,A)	Tyr381 Asp303 Asp301 Glu305
1ctn(A)	3aqu(C,B,A,D)	Tyr185 Asp115 Asp113 Glu117
1ctn(A)	3w4r(A)	Tyr217 Asp146 Asp144 Glu148
1ctn(A)	3as3(A) 3as2(A) 3art(A) 3as0(A) 3ars(A) 3as1(A) 3aru(A)	Tyr370 Asp292 Asp290 Glu294
1ctn(A)	2pi6(A) 5z4v(A)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	4mnl(A) 4mnm(A)	Tyr192 Asp118 Asp116 Gln120
1ctn(A)	5dez(B,A)	Tyr381 Asp303 Asp301 Glu305
1ctn(A)	5wsj(A) 5wsi(A) 5wsm(A) 5yar(A) 5z05(A) 5z3s(A) 5z4w(A)	Tyr185 Ala117 Asp115 Leu119
1ctn(A)	3alg(A)	Tyr184 Asp114 Asp112 Gln116
1ctn(A)	5xep(C,E,F,D,A,B)	x x x x
1ctn(A)	5xwf(A) 5xwq(A) 5yuq(B,A)	x x x x
1ctn(A)	5z7m(A) 5z7n(A) 5z7o(A) 5z7p(A)	x x x x
1ctn(A)	5zl9(A)	x x x x
1ctn(A)	6bt9(B,A)	x x x x
1ctn(A)	6epb(A)	x x x x
1ctn(A)	6f8n(B,A)	x x x x
1ctn(A)	6g9c(B,A) 6g9e(C,E,F,D,A,B)	x x x x
1ctn(A)	6hm1(A)	x x x x
1ctn(A)	6igy(A)	x x x x
1ctn(A)	6inx(A)	x x x x
1ctn(A)	6jav(A) 6jaw(A) 6jax(A) 6jay(A)	x x x x
1ctn(A)	6ogd(C,F,O,L,I)	x x x x
1ctn(A)	6jjr(A) 6jk6(A)	x x x x
1ctn(A)	6jk9(B,A) 7c34(B,A)	x x x x
1ctn(A)	6jkf(B,A)	x x x x
1ctn(A)	6jm7(A) 6jmb(A)	x x x x
1ctn(A)	6jm8(A)	x x x x
1ctn(A)	6kst(B,A) 6kxl(B,A)	x x x x
1ctn(A)	6kxm(B,A)	x x x x
1ctn(A)	6kxn(B,A)	x x x x
1ctn(A)	6ldu(A)	x x x x
1ctn(A)	6le7(A)	x x x x
1ctn(A)	6le8(A)	x x x x
1ctn(A)	6t9m(AAA)	x x x x
1ctn(A)	6tsb(AAA)	x x x x
1ctn(A)	7c92(B,A)	x x x x
1ctn(A)	7cb1(B,A)	x x x x