M-CSA Mechanism and Catalytic Site Atlas

Polynucleotide 5'-hydroxyl-kinase (M-CSA:625)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1ltq

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1rc8(A), 1rpz(A), 1rrc(A), 2ia5(A, B, C, D, E, F, G, H, I, J, K, L)

PDB sequences homologous to 1ltq

Reference PDB chains/ identical chains	Homologous PDB chains	Lys15A Arg126A Asp35A Asp165A
1ltq(A) 2ia5(I,E,K,B,F,G,L,D,J,C,A,H) 1rrc(A) 1rpz(A) 1rc8(A)	1ltq(A) 2ia5(I,E,K,B,F,G,L,D,J,C,A,H) 1rrc(A) 1rpz(A) 1rc8(A)	Lys15 Arg126 Asp35 Asp165
1ltq(A) 2ia5(I,E,K,B,F,G,L,D,J,C,A,H) 1rrc(A) 1rpz(A) 1rc8(A)	5uj0(B,A)	not aligned not aligned not aligned Asp9
1ltq(A) 2ia5(I,E,K,B,F,G,L,D,J,C,A,H) 1rrc(A) 1rpz(A) 1rc8(A)	4xru(D,A) 4xrp(A,D)	Lys24 Arg126 Asp44 Asp183
1ltq(A) 2ia5(I,E,K,B,F,G,L,D,J,C,A,H) 1rrc(A) 1rpz(A) 1rc8(A)	1ly1(A)	Lys15 Arg126 Asp35 Asp165