M-CSA Mechanism and Catalytic Site Atlas

Purine-nucleoside phosphorylase (M-CSA:695)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 2bsx

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

3enz(A, B, C, D, E, F)

PDB sequences homologous to 2bsx

Reference PDB chains/ identical chains	Homologous PDB chains	Arg27A Arg88A Asp206A Arg45A(AD)
2bsx(A) 3enz(E,C,F,D,A,B)	4tti(C,E,F,D,A,B) 4tta(E,C,F,D,A,B) 4ttj(B,A,D)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	3c74(C,E,F,D,A,B)	x
2bsx(A) 3enz(E,C,F,D,A,B)	5mx6(E,C,F,D,A,B) 5mx4(C,E,F,D,A,B) 5mx8(A)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	4r2w(E,C,F,D,A,B) 4r2x(C,E,F,D,A,B)	Ile218
2bsx(A) 3enz(E,C,F,D,A,B)	2oxf(A,F)	Ile217
2bsx(A) 3enz(E,C,F,D,A,B)	6xz2(C,B,A)	x
2bsx(A) 3enz(E,C,F,D,A,B)	1u1g(E,C,F,D,A,B) 1u1e(E,C,F,D,A,B) 1tgy(B,A) 1tgv(B,A) 1u1d(E,C,F,D,A,B) 1u1c(C,E,F,D,A,B) 1u1f(C,E,F,D,A,B)	Ile223
2bsx(A) 3enz(E,C,F,D,A,B)	3uay(A) 3uaz(A)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	1vhw(E,C,F,D,A,B) 1vhj(E,C,F,D,A,B)	Ser206
2bsx(A) 3enz(E,C,F,D,A,B)	4i2v(C,E,F,D,A,B) 4ny1(B,A) 4jp5(E,C,F,D,A,B) 4of4(B,A)	Ile220
2bsx(A) 3enz(E,C,F,D,A,B)	3occ(C,E,F,D,A,B)	Ser204
2bsx(A) 3enz(E,C,F,D,A,B)	5znc(A) 5zni(A)	x
2bsx(A) 3enz(E,C,F,D,A,B)	3phc(C,E,F,D,A,B)	Asp207
2bsx(A) 3enz(E,C,F,D,A,B)	1z39(A) 1z33(A) 1z37(A) 1z35(A) 1z38(A) 1z34(A) 1z36(A)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	5lhv(C,E,F,D,A,B)	Ile217
2bsx(A) 3enz(E,C,F,D,A,B)	2oec(E,C,F,D,A,B) 2rj3(E,C,F,D,A,B) 2i8a(E,C,F,D,A,B) 2qdk(E,C,F,D,A,B) 2iq5(B,A)	Ile219
2bsx(A) 3enz(E,C,F,D,A,B)	2ac7(B,A) 3uaw(A) 3uax(A) 3uav(A)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	5lu0(C,E,F,D,A,B) 6f4x(C,E,F,D,A,B) 6f5a(E,C,F,D,A,B) 6f4w(C,E,F,D,A,B) 6f5i(E,C,F,D,A,B) 6f52(E,C,F,D,A,B) 6g7x(C,E,F,D,A,B)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	3of3(E,C,G,F,D,L,I,A,H,J,B,K)	Ser204
2bsx(A) 3enz(E,C,F,D,A,B)	4m3n(C,B,A) 4mar(C,B,A)	Ser225
2bsx(A) 3enz(E,C,F,D,A,B)	1ybf(C,B,A)	Ser209
2bsx(A) 3enz(E,C,F,D,A,B)	1q1g(C,E,F,D,A,B) 1nw4(C,E,F,D,A,B)	Asp208
2bsx(A) 3enz(E,C,F,D,A,B)	2bsx(A) 3enz(E,C,F,D,A,B)	Asp206
2bsx(A) 3enz(E,C,F,D,A,B)	4ts9(C,B,A)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	2isc(C,E,F,D,A,B)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	2i4t(C,B,A)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	4mch(A) 4lnh(A) 4mci(A)	Val225
2bsx(A) 3enz(E,C,F,D,A,B)	3fow(B,A)	Asp208
2bsx(A) 3enz(E,C,F,D,A,B)	6aqs(A)	x
2bsx(A) 3enz(E,C,F,D,A,B)	4tym(A)	Ser225
2bsx(A) 3enz(E,C,F,D,A,B)	2b94(A)	Asp229
2bsx(A) 3enz(E,C,F,D,A,B)	3emv(A)	Asp207
2bsx(A) 3enz(E,C,F,D,A,B)	4yjk(E,C,F,D,A,B)	Ile218
2bsx(A) 3enz(E,C,F,D,A,B)	1pr2(C,B,A) 1pr1(C,B,A) 1pr0(C,B,A) 1pr4(C,B,A) 1pr5(C,B,A) 1pw7(C,B,A) 1pr6(C,B,A)	Ser204
2bsx(A) 3enz(E,C,F,D,A,B)	1a69(C,B,A) 1oty(C,B,A) 1ecp(E,C,F,D,A,B) 1ou4(C,B,A)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	4r31(C,E,F,D,A,B)	Ile240
2bsx(A) 3enz(E,C,F,D,A,B)	1xe3(E,C,F,D,A,B)	Ser213
2bsx(A) 3enz(E,C,F,D,A,B)	6aqu(B,A)	x
2bsx(A) 3enz(E,C,F,D,A,B)	3mb8(B,A)	Asp210
2bsx(A) 3enz(E,C,F,D,A,B)	1rxs(C,m,O,L,o,d,Q,a,N,G,R,i,e,M,E,P,F,l,c,I,A,j,J,h,b,D,H,k,B,K) 3kvv(E,C,F,D,A,B) 1rxu(C,E,N,P,G,R,F,O,D,L,I,A,H,J,Q,M,B,K) 1rxc(E,C,G,F,D,L,I,A,H,J,B,K) 1rxy(B,A) 1k3f(E,C,F,D,A,B) 1lx7(B,A) 1t0u(B,A)	Ile220
2bsx(A) 3enz(E,C,F,D,A,B)	1ovg(C,B,A) 1oum(C,B,A) 1otx(C,B,A) 1ov6(C,B,A)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	1sq6(A)	Asp214
2bsx(A) 3enz(E,C,F,D,A,B)	4da0(A) 4dar(A) 4dan(B,A) 4d8v(B,A) 4dao(B,A) 4d9h(B,A) 4d8y(E,C,F,D,A,B) 4da7(A) 4dab(A) 4d98(B,A) 4da8(A) 4d8x(A) 4dae(A) 4da6(A)	Ser222
2bsx(A) 3enz(E,C,F,D,A,B)	1jpv(C,B,A) 1je1(C,E,F,D,A,B) 1jdt(C,B,A) 1jdu(C,B,A) 1jdv(C,E,F,D,A,B) 1je0(C,B,A) 1jp7(C,B,A) 1jds(E,C,F,D,A,B) 1jdz(C,B,A)	Ser204
2bsx(A) 3enz(E,C,F,D,A,B)	1sj9(C,E,F,D,A,B) 3fwp(C,E,F,D,A,B) 4ogk(C,E,F,D,A,B) 4e1v(E,C,G,F,D,I,A,H,B) 1ryz(E,C,F,D,A,B) 2hwu(E,C,F,D,A,B) 2pga(E,C,F,D,A,B) 1zl2(E,C,F,D,A,B) 1y1r(E,C,F,D,A,B) 3dps(A,F) 1y1s(C,E,F,D,A,B) 2hn9(C,E,F,D,A,B) 2hrd(E,C,F,D,A,B) 1y1q(C,E,F,D,A,B) 3ddo(C,E,F,D,A,B) 2hsw(B,A) 1y1t(A,F)	Ile220
2bsx(A) 3enz(E,C,F,D,A,B)	3opv(E,C,G,F,D,L,I,A,H,J,B,K)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	1odi(E,C,F,D,A,B) 1odk(E,C,F,D,A,B) 1odl(C,E,F,D,A,B) 1odj(C,E,F,D,A,B)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	3qpb(E,C,N,P,G,R,F,O,D,L,I,A,H,J,Q,M,B,K)	Val243
2bsx(A) 3enz(E,C,F,D,A,B)	3onv(C,B,A) 3ooh(E,C,N,P,R,G,F,O,D,L,I,A,H,J,Q,M,B,K) 3ooe(E,C,F,D,A,B) 3ut6(C,B,A) 1pk9(C,B,A) 5i3c(C,B,A) 1k9s(C,E,F,D,A,B) 1pke(C,B,A) 4rj2(E,C,F,D,A,B) 1pk7(C,B,A) 5iu6(C,B,A) 4ts3(C,E,F,D,A,B)	Ser203
2bsx(A) 3enz(E,C,F,D,A,B)	3pns(C,E,G,F,D,L,I,A,H,J,B,K) 3o6v(B,A)	Ile227
2bsx(A) 3enz(E,C,F,D,A,B)	5epu(E,C,F,D,A,B) 4ogl(E,C,F,D,A,B) 4lzw(C,E,F,D,A,B) 5efo(E,C,F,D,A,B) 4g8j(C,E,F,D,A,B) 4u2k(C,E,F,D,A,B) 4ip0(E,C,F,D,A,B) 5c80(C,E,F,D,A,B) 4oeh(C,E,F,D,A,B) 4k6o(C,E,F,D,A,B) 4h1t(C,E,F,D,A,B) 5miw(E,C,F,D,A,B) 5lok(E,C,F,D,A,B) 5m2t(C,E,F,D,A,B) 5our(C,E,F,D,A,B) 6eyp(C,E,F,D,A,B) 6rca(C,E,F,D,A,B) 6z9z(C,E,F,D,A,B)	Ile219