6-pyruvoyltetrahydropterin synthase (M-CSA:84)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P27213

Reference Sequence Homologue Cys42 Glu133 His48 His50 His23 His89 Asp88
P27213
FunTreePfam
P27213
FunTreePfam
Cys42 Glu133 His48 His50 His23 His89 Asp88
P27213
FunTreePfam
P80081
FunTreePfam
not aligned Glu92 not aligned not aligned His27 His53 Asp52
P27213
FunTreePfam
P48611
FunTreePfam
Cys38 Glu130 His44 His46 His19 His85 Asp84
P27213
FunTreePfam
O02058
FunTreePfam
Cys38 Glu129 His44 His46 His19 His84 Asp83
P27213
FunTreePfam
Q1ZXI0
FunTreePfam
Cys36 Glu124 His40 His42 His17 His81 Asp80
P27213
FunTreePfam
Q5REZ5
FunTreePfam
Cys43 Glu134 His49 His51 His24 His90 Asp89
P27213
FunTreePfam
Q9R1Z7
FunTreePfam
Cys42 Glu133 His48 His50 His23 His89 Asp88
P27213
FunTreePfam
Q03393
FunTreePfam
Cys43 Glu134 His49 His51 His24 His90 Asp89
P27213
FunTreePfam
Q90W95
FunTreePfam
Cys45 Glu136 His51 His53 His26 His92 Asp91