M-CSA Mechanism and Catalytic Site Atlas

Adenosylhomocysteinase (M-CSA:90)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1b3r

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1k0u(A, B, C, D, E, F, G, H), 1ky4(A, B, C, D), 2h5l(A, B, C, D, E, F, G, H)

PDB sequences homologous to 1b3r

Reference PDB chains/ identical chains	Homologous PDB chains	Ser77A Gln364A Ser360A His300A Asp130A Lys185A Asp189A Asn190A Cys194A His54A Glu155A Ser82A Asn180A His352A
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3nj4(B,D,A,C)	Ser81 Gln368 Ser364 His304 Asp134 Lys189 Asp193 Asn194 Cys198 His58 Glu159 Ser86 Asn184 His356
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3g1u(B,D,A,C)	Ser75 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His52 Glu155 Ser80 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	2zj0(B,D,A,C) 2zj1(B,A,D,C) 3dhy(B,D,A,C) 2ziz(B,D,A,C)	Ser92 Gln428 Ser424 His363 Asp156 Lys248 Asp252 Asn253 Thr257 His69 Glu218 Ser97 Asn243 His416
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	4pfj(B,A) 4pgf(B,A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1a7a(B,A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5jpi(B,A,D,C) 5tj9(B,A,D,C) 5jxw(B,A,D,C) 5hm8(E,F,B,G,D,H,A,C) 5t8k(B,D,A,C) 5utu(E,F,B,G,D,H,A,C) 5tls(B,A,D,C)	Ser79 Gln425 Ser421 His359 Asp140 Lys244 Asp248 Asn249 Cys253 His56 Glu214 Ser84 Asn239 His413
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5axc(A,C) 5axb(A,C) 5axa(A,C) 5axd(A,C)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3ond(B,A) 3one(B,A) 3onf(B,A)	Ser88 Gln419 Ser415 His353 Asp142 Lys238 Asp242 Asn243 Cys247 His65 Glu208 Ser93 Asn233 His407
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3h9u(B,D,A,C)	Ser74 Gln363 Ser359 His299 Asp129 Lys184 Asp188 Asn189 Cys193 His51 Glu154 Ser79 Asn179 His351
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3mtg(B,A)	Ala90 Gln376 Thr372 His313 Asp143 Lys198 Asp202 Asn203 Cys207 His67 Glu168 Ser95 Asn193 Val364
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3d64(B,A) 3glq(B,A)	Ser106 Gln427 Ser423 His365 Asp160 Lys250 Asp254 Asn255 Cys259 His83 Glu220 Ser111 Asn245 His415
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5tow(B,A) 5tov(B,A)	Gly67 Gln351 Ser347 His287 Asp117 Lys172 Asp176 Asn177 Thr181 His44 Glu142 Ser72 Asn167 His339
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3x2f(B,A) 3x2e(B,D,A,C)	Gly65 Gln349 Ser345 His285 Asp115 Lys170 Asp174 Asn175 Thr179 His42 Glu140 Ser70 Asn165 His337
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	4yvf(B,A) 1li4(A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3ce6(B,D,A,C)	Ser91 Gln427 Ser423 His362 Asp155 Lys247 Asp251 Asn252 Thr256 His68 Glu217 Ser96 Asn242 His415
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3gvp(C,B,A,D)	Ala85 Gln371 Thr367 His308 Asp138 Lys193 Asp197 Asn198 Cys202 His62 Glu163 Ser90 Asn188 Val359
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1d4f(B,D,A,C) 1ky5(B,A,D,C)	Ser77 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5w49(B,A) 5w4b(E,F,B,D,A,C)	Ser75 Gln362 Ser358 His298 Asp128 Lys183 Asp187 Asn188 Cys192 His52 Glu153 Ser80 Asn178 His350
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6aph(A)	Ser89 Gln378 Ser374 His314 Asp144 Lys199 Asp203 Asn204 Cys208 His66 Glu169 Ser94 Asn194 His366
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1xwf(B,D,A,C)	Ser77 Gln364 Ser360 His300 Asp130 Asn185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	Ser77 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5v96(B,D,A,C)	Ser90 Gln415 Ser411 His350 Asp144 Lys235 Asp239 Asn240 Cys244 His67 Glu205 Ser95 Asn230 His403
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1v8b(B,A,D,C)	Ser77 Gln410 Ser406 His345 Asp134 Lys230 Asp234 Asn235 Cys239 His54 Glu200 Ser82 Asn225 His398
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5m5k(B,D,A,C) 5m67(B,D,A,C) 5m66(B,A,D,C) 4lvc(B,A,D,C) 5m65(B,A) 6exi(B,A,D,C)	Ser87 Gln410 Ser406 His348 Asp141 Lys233 Asp237 Asn238 Cys242 His64 Glu203 Ser92 Asn228 His398
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3n58(B,D,A,C)	Ser76 Gln397 Ser393 His335 Asp130 Lys220 Asp224 Asn225 Cys229 His53 Glu190 Ser81 Asn215 His385
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3m(A)	Ser76 Gln386 Ser382 His315 Asp131 Lys186 Asp190 Asn191 Cys195 His53 Glu156 Ser81 Asn181 His374
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3m(B,D,C)	Ser75 Gln385 Ser381 His314 Asp130 Lys185 Asp189 Asn190 Cys194 His52 Glu155 Ser80 Asn180 His373
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3n(B,A,D,C) 6f3o(B,A,D,C) 6f3p(A,C) 6f3q(B,A,D,C)	Ser87 Gln397 Ser393 His326 Asp142 Lys197 Asp201 Asn202 Cys206 His64 Glu167 Ser92 Asn192 His385
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6gbn(B,A,D,C)	Ser82 Gln371 Ser367 His307 Asp137 Lys192 Asp196 Asn197 Cys201 His59 Glu162 Ser87 Asn187 His359
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6uk3(B,A,D,C)	Ser95 Gln420 Ser416 His355 Asp149 Lys240 Asp244 Asn245 Cys249 His72 Glu210 Ser100 Asn235 His408
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3nj4(B,D,A,C)	Ser81 Gln368 Ser364 His304 Asp134 Lys189 Asp193 Asn194 Cys198 His58 Glu159 Ser86 Asn184 His356
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3g1u(B,D,A,C)	Ser75 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His52 Glu155 Ser80 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	2zj0(B,D,A,C) 2zj1(B,A,D,C) 3dhy(B,D,A,C) 2ziz(B,D,A,C)	Ser92 Gln428 Ser424 His363 Asp156 Lys248 Asp252 Asn253 Thr257 His69 Glu218 Ser97 Asn243 His416
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	4pfj(B,A) 4pgf(B,A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1a7a(B,A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5jpi(B,A,D,C) 5tj9(B,A,D,C) 5jxw(B,A,D,C) 5hm8(E,F,B,G,D,H,A,C) 5t8k(B,D,A,C) 5utu(E,F,B,G,D,H,A,C) 5tls(B,A,D,C)	Ser79 Gln425 Ser421 His359 Asp140 Lys244 Asp248 Asn249 Cys253 His56 Glu214 Ser84 Asn239 His413
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5axc(A,C) 5axb(A,C) 5axa(A,C) 5axd(A,C)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3ond(B,A) 3one(B,A) 3onf(B,A)	Ser88 Gln419 Ser415 His353 Asp142 Lys238 Asp242 Asn243 Cys247 His65 Glu208 Ser93 Asn233 His407
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3h9u(B,D,A,C)	Ser74 Gln363 Ser359 His299 Asp129 Lys184 Asp188 Asn189 Cys193 His51 Glu154 Ser79 Asn179 His351
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3mtg(B,A)	Ala90 Gln376 Thr372 His313 Asp143 Lys198 Asp202 Asn203 Cys207 His67 Glu168 Ser95 Asn193 Val364
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3d64(B,A) 3glq(B,A)	Ser106 Gln427 Ser423 His365 Asp160 Lys250 Asp254 Asn255 Cys259 His83 Glu220 Ser111 Asn245 His415
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5tow(B,A) 5tov(B,A)	Gly67 Gln351 Ser347 His287 Asp117 Lys172 Asp176 Asn177 Thr181 His44 Glu142 Ser72 Asn167 His339
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3x2f(B,A) 3x2e(B,D,A,C)	Gly65 Gln349 Ser345 His285 Asp115 Lys170 Asp174 Asn175 Thr179 His42 Glu140 Ser70 Asn165 His337
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	4yvf(B,A) 1li4(A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3ce6(B,D,A,C)	Ser91 Gln427 Ser423 His362 Asp155 Lys247 Asp251 Asn252 Thr256 His68 Glu217 Ser96 Asn242 His415
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3gvp(C,B,A,D)	Ala85 Gln371 Thr367 His308 Asp138 Lys193 Asp197 Asn198 Cys202 His62 Glu163 Ser90 Asn188 Val359
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1d4f(B,D,A,C) 1ky5(B,A,D,C)	Ser77 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5w49(B,A) 5w4b(E,F,B,D,A,C)	Ser75 Gln362 Ser358 His298 Asp128 Lys183 Asp187 Asn188 Cys192 His52 Glu153 Ser80 Asn178 His350
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6aph(A)	Ser89 Gln378 Ser374 His314 Asp144 Lys199 Asp203 Asn204 Cys208 His66 Glu169 Ser94 Asn194 His366
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1xwf(B,D,A,C)	Ser77 Gln364 Ser360 His300 Asp130 Asn185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	Ser77 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5v96(B,D,A,C)	Ser90 Gln415 Ser411 His350 Asp144 Lys235 Asp239 Asn240 Cys244 His67 Glu205 Ser95 Asn230 His403
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1v8b(B,A,D,C)	Ser77 Gln410 Ser406 His345 Asp134 Lys230 Asp234 Asn235 Cys239 His54 Glu200 Ser82 Asn225 His398
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5m5k(B,D,A,C) 5m67(B,D,A,C) 5m66(B,A,D,C) 4lvc(B,A,D,C) 5m65(B,A) 6exi(B,A,D,C)	Ser87 Gln410 Ser406 His348 Asp141 Lys233 Asp237 Asn238 Cys242 His64 Glu203 Ser92 Asn228 His398
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3n58(B,D,A,C)	Ser76 Gln397 Ser393 His335 Asp130 Lys220 Asp224 Asn225 Cys229 His53 Glu190 Ser81 Asn215 His385
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3m(A)	Ser76 Gln386 Ser382 His315 Asp131 Lys186 Asp190 Asn191 Cys195 His53 Glu156 Ser81 Asn181 His374
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3m(B,D,C)	Ser75 Gln385 Ser381 His314 Asp130 Lys185 Asp189 Asn190 Cys194 His52 Glu155 Ser80 Asn180 His373
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3n(B,A,D,C) 6f3o(B,A,D,C) 6f3p(A,C) 6f3q(B,A,D,C)	Ser87 Gln397 Ser393 His326 Asp142 Lys197 Asp201 Asn202 Cys206 His64 Glu167 Ser92 Asn192 His385
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6gbn(B,A,D,C)	Ser82 Gln371 Ser367 His307 Asp137 Lys192 Asp196 Asn197 Cys201 His59 Glu162 Ser87 Asn187 His359
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6uk3(B,A,D,C)	Ser95 Gln420 Ser416 His355 Asp149 Lys240 Asp244 Asn245 Cys249 His72 Glu210 Ser100 Asn235 His408
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3nj4(B,D,A,C)	Ser81 Gln368 Ser364 His304 Asp134 Lys189 Asp193 Asn194 Cys198 His58 Glu159 Ser86 Asn184 His356
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3g1u(B,D,A,C)	Ser75 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His52 Glu155 Ser80 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	2zj0(B,D,A,C) 2zj1(B,A,D,C) 3dhy(B,D,A,C) 2ziz(B,D,A,C)	Ser92 Gln428 Ser424 His363 Asp156 Lys248 Asp252 Asn253 Thr257 His69 Glu218 Ser97 Asn243 His416
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	4pfj(B,A) 4pgf(B,A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1a7a(B,A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5jpi(B,A,D,C) 5tj9(B,A,D,C) 5jxw(B,A,D,C) 5hm8(E,F,B,G,D,H,A,C) 5t8k(B,D,A,C) 5utu(E,F,B,G,D,H,A,C) 5tls(B,A,D,C)	Ser79 Gln425 Ser421 His359 Asp140 Lys244 Asp248 Asn249 Cys253 His56 Glu214 Ser84 Asn239 His413
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5axc(A,C) 5axb(A,C) 5axa(A,C) 5axd(A,C)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3ond(B,A) 3one(B,A) 3onf(B,A)	Ser88 Gln419 Ser415 His353 Asp142 Lys238 Asp242 Asn243 Cys247 His65 Glu208 Ser93 Asn233 His407
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3h9u(B,D,A,C)	Ser74 Gln363 Ser359 His299 Asp129 Lys184 Asp188 Asn189 Cys193 His51 Glu154 Ser79 Asn179 His351
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3mtg(B,A)	Ala90 Gln376 Thr372 His313 Asp143 Lys198 Asp202 Asn203 Cys207 His67 Glu168 Ser95 Asn193 Val364
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3d64(B,A) 3glq(B,A)	Ser106 Gln427 Ser423 His365 Asp160 Lys250 Asp254 Asn255 Cys259 His83 Glu220 Ser111 Asn245 His415
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5tow(B,A) 5tov(B,A)	Gly67 Gln351 Ser347 His287 Asp117 Lys172 Asp176 Asn177 Thr181 His44 Glu142 Ser72 Asn167 His339
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3x2f(B,A) 3x2e(B,D,A,C)	Gly65 Gln349 Ser345 His285 Asp115 Lys170 Asp174 Asn175 Thr179 His42 Glu140 Ser70 Asn165 His337
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	4yvf(B,A) 1li4(A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3ce6(B,D,A,C)	Ser91 Gln427 Ser423 His362 Asp155 Lys247 Asp251 Asn252 Thr256 His68 Glu217 Ser96 Asn242 His415
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3gvp(C,B,A,D)	Ala85 Gln371 Thr367 His308 Asp138 Lys193 Asp197 Asn198 Cys202 His62 Glu163 Ser90 Asn188 Val359
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1d4f(B,D,A,C) 1ky5(B,A,D,C)	Ser77 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5w49(B,A) 5w4b(E,F,B,D,A,C)	Ser75 Gln362 Ser358 His298 Asp128 Lys183 Asp187 Asn188 Cys192 His52 Glu153 Ser80 Asn178 His350
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6aph(A)	Ser89 Gln378 Ser374 His314 Asp144 Lys199 Asp203 Asn204 Cys208 His66 Glu169 Ser94 Asn194 His366
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1xwf(B,D,A,C)	Ser77 Gln364 Ser360 His300 Asp130 Asn185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	Ser77 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5v96(B,D,A,C)	Ser90 Gln415 Ser411 His350 Asp144 Lys235 Asp239 Asn240 Cys244 His67 Glu205 Ser95 Asn230 His403
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1v8b(B,A,D,C)	Ser77 Gln410 Ser406 His345 Asp134 Lys230 Asp234 Asn235 Cys239 His54 Glu200 Ser82 Asn225 His398
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5m5k(B,D,A,C) 5m67(B,D,A,C) 5m66(B,A,D,C) 4lvc(B,A,D,C) 5m65(B,A) 6exi(B,A,D,C)	Ser87 Gln410 Ser406 His348 Asp141 Lys233 Asp237 Asn238 Cys242 His64 Glu203 Ser92 Asn228 His398
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3n58(B,D,A,C)	Ser76 Gln397 Ser393 His335 Asp130 Lys220 Asp224 Asn225 Cys229 His53 Glu190 Ser81 Asn215 His385
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3m(A)	Ser76 Gln386 Ser382 His315 Asp131 Lys186 Asp190 Asn191 Cys195 His53 Glu156 Ser81 Asn181 His374
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3m(B,D,C)	Ser75 Gln385 Ser381 His314 Asp130 Lys185 Asp189 Asn190 Cys194 His52 Glu155 Ser80 Asn180 His373
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3n(B,A,D,C) 6f3o(B,A,D,C) 6f3p(A,C) 6f3q(B,A,D,C)	Ser87 Gln397 Ser393 His326 Asp142 Lys197 Asp201 Asn202 Cys206 His64 Glu167 Ser92 Asn192 His385
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6gbn(B,A,D,C)	Ser82 Gln371 Ser367 His307 Asp137 Lys192 Asp196 Asn197 Cys201 His59 Glu162 Ser87 Asn187 His359
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6uk3(B,A,D,C)	Ser95 Gln420 Ser416 His355 Asp149 Lys240 Asp244 Asn245 Cys249 His72 Glu210 Ser100 Asn235 His408
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3nj4(B,D,A,C)	Ser81 Gln368 Ser364 His304 Asp134 Lys189 Asp193 Asn194 Cys198 His58 Glu159 Ser86 Asn184 His356
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3g1u(B,D,A,C)	Ser75 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His52 Glu155 Ser80 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	2zj0(B,D,A,C) 2zj1(B,A,D,C) 3dhy(B,D,A,C) 2ziz(B,D,A,C)	Ser92 Gln428 Ser424 His363 Asp156 Lys248 Asp252 Asn253 Thr257 His69 Glu218 Ser97 Asn243 His416
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	4pfj(B,A) 4pgf(B,A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1a7a(B,A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5jpi(B,A,D,C) 5tj9(B,A,D,C) 5jxw(B,A,D,C) 5hm8(E,F,B,G,D,H,A,C) 5t8k(B,D,A,C) 5utu(E,F,B,G,D,H,A,C) 5tls(B,A,D,C)	Ser79 Gln425 Ser421 His359 Asp140 Lys244 Asp248 Asn249 Cys253 His56 Glu214 Ser84 Asn239 His413
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5axc(A,C) 5axb(A,C) 5axa(A,C) 5axd(A,C)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3ond(B,A) 3one(B,A) 3onf(B,A)	Ser88 Gln419 Ser415 His353 Asp142 Lys238 Asp242 Asn243 Cys247 His65 Glu208 Ser93 Asn233 His407
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3h9u(B,D,A,C)	Ser74 Gln363 Ser359 His299 Asp129 Lys184 Asp188 Asn189 Cys193 His51 Glu154 Ser79 Asn179 His351
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3mtg(B,A)	Ala90 Gln376 Thr372 His313 Asp143 Lys198 Asp202 Asn203 Cys207 His67 Glu168 Ser95 Asn193 Val364
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3d64(B,A) 3glq(B,A)	Ser106 Gln427 Ser423 His365 Asp160 Lys250 Asp254 Asn255 Cys259 His83 Glu220 Ser111 Asn245 His415
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5tow(B,A) 5tov(B,A)	Gly67 Gln351 Ser347 His287 Asp117 Lys172 Asp176 Asn177 Thr181 His44 Glu142 Ser72 Asn167 His339
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3x2f(B,A) 3x2e(B,D,A,C)	Gly65 Gln349 Ser345 His285 Asp115 Lys170 Asp174 Asn175 Thr179 His42 Glu140 Ser70 Asn165 His337
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	4yvf(B,A) 1li4(A)	Ser78 Gln365 Ser361 His301 Asp131 Lys186 Asp190 Asn191 Cys195 His55 Glu156 Ser83 Asn181 His353
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3ce6(B,D,A,C)	Ser91 Gln427 Ser423 His362 Asp155 Lys247 Asp251 Asn252 Thr256 His68 Glu217 Ser96 Asn242 His415
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3gvp(C,B,A,D)	Ala85 Gln371 Thr367 His308 Asp138 Lys193 Asp197 Asn198 Cys202 His62 Glu163 Ser90 Asn188 Val359
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1d4f(B,D,A,C) 1ky5(B,A,D,C)	Ser77 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5w49(B,A) 5w4b(E,F,B,D,A,C)	Ser75 Gln362 Ser358 His298 Asp128 Lys183 Asp187 Asn188 Cys192 His52 Glu153 Ser80 Asn178 His350
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6aph(A)	Ser89 Gln378 Ser374 His314 Asp144 Lys199 Asp203 Asn204 Cys208 His66 Glu169 Ser94 Asn194 His366
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1xwf(B,D,A,C)	Ser77 Gln364 Ser360 His300 Asp130 Asn185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	Ser77 Gln364 Ser360 His300 Asp130 Lys185 Asp189 Asn190 Cys194 His54 Glu155 Ser82 Asn180 His352
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5v96(B,D,A,C)	Ser90 Gln415 Ser411 His350 Asp144 Lys235 Asp239 Asn240 Cys244 His67 Glu205 Ser95 Asn230 His403
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	1v8b(B,A,D,C)	Ser77 Gln410 Ser406 His345 Asp134 Lys230 Asp234 Asn235 Cys239 His54 Glu200 Ser82 Asn225 His398
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	5m5k(B,D,A,C) 5m67(B,D,A,C) 5m66(B,A,D,C) 4lvc(B,A,D,C) 5m65(B,A) 6exi(B,A,D,C)	Ser87 Gln410 Ser406 His348 Asp141 Lys233 Asp237 Asn238 Cys242 His64 Glu203 Ser92 Asn228 His398
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	3n58(B,D,A,C)	Ser76 Gln397 Ser393 His335 Asp130 Lys220 Asp224 Asn225 Cys229 His53 Glu190 Ser81 Asn215 His385
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3m(A)	Ser76 Gln386 Ser382 His315 Asp131 Lys186 Asp190 Asn191 Cys195 His53 Glu156 Ser81 Asn181 His374
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3m(B,D,C)	Ser75 Gln385 Ser381 His314 Asp130 Lys185 Asp189 Asn190 Cys194 His52 Glu155 Ser80 Asn180 His373
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6f3n(B,A,D,C) 6f3o(B,A,D,C) 6f3p(A,C) 6f3q(B,A,D,C)	Ser87 Gln397 Ser393 His326 Asp142 Lys197 Asp201 Asn202 Cys206 His64 Glu167 Ser92 Asn192 His385
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6gbn(B,A,D,C)	Ser82 Gln371 Ser367 His307 Asp137 Lys192 Asp196 Asn197 Cys201 His59 Glu162 Ser87 Asn187 His359
1b3r(B,A,D,C) 2h5l(E,F,B,G,D,H,A,C) 1k0u(E,F,B,G,D,C,A,H) 1ky4(C,B,A,D)	6uk3(B,A,D,C)	Ser95 Gln420 Ser416 His355 Asp149 Lys240 Asp244 Asn245 Cys249 His72 Glu210 Ser100 Asn235 His408