M-CSA Mechanism and Catalytic Site Atlas

Hydroxymethylglutaryl-CoA reductase (NADPH) (M-CSA:93)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1dqa

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1dq8(A, B, C, D), 1dq9(A, B, C, D), 1hw8(A, B, C, D), 1hw9(A, B, C, D), 1hwi(A, B, C, D), 1hwj(A, B, C, D), 1hwk(A, B, C, D), 1hwl(A, B, C, D)

PDB sequences homologous to 1dqa

Reference PDB chains/ identical chains	Homologous PDB chains	Glu559(138)B His866(445)B Lys691(270)A Asp767(346)A
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	Glu138 His445 Lys270 Asp346
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	6hr7(B,A) 6hr8(C,E,F,D,A,B)	Glu122 His422 Lys257 Asp332
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	2q1l(C,B,A,D) 3ccz(C,B,A,D) 3cda(C,B,A,D) 3bgl(C,B,A,D) 3cd7(C,B,A,D) 2r4f(C,B,A,D) 3ccw(C,B,A,D) 3cd0(C,B,A,D) 3cdb(C,B,A,D) 3cd5(C,B,A,D) 3cct(C,B,A,D) 2q6b(C,B,A,D) 2q6c(C,B,A,D)	Glu125 His432 Lys257 Asp333
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	Glu138 His445 Lys270 Asp346
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	6hr7(B,A) 6hr8(C,E,F,D,A,B)	Glu122 His422 Lys257 Asp332
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	2q1l(C,B,A,D) 3ccz(C,B,A,D) 3cda(C,B,A,D) 3bgl(C,B,A,D) 3cd7(C,B,A,D) 2r4f(C,B,A,D) 3ccw(C,B,A,D) 3cd0(C,B,A,D) 3cdb(C,B,A,D) 3cd5(C,B,A,D) 3cct(C,B,A,D) 2q6b(C,B,A,D) 2q6c(C,B,A,D)	Glu125 His432 Lys257 Asp333
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	Glu138 His445 Lys270 Asp346
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	6hr7(B,A) 6hr8(C,E,F,D,A,B)	Glu122 His422 Lys257 Asp332
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	2q1l(C,B,A,D) 3ccz(C,B,A,D) 3cda(C,B,A,D) 3bgl(C,B,A,D) 3cd7(C,B,A,D) 2r4f(C,B,A,D) 3ccw(C,B,A,D) 3cd0(C,B,A,D) 3cdb(C,B,A,D) 3cd5(C,B,A,D) 3cct(C,B,A,D) 2q6b(C,B,A,D) 2q6c(C,B,A,D)	Glu125 His432 Lys257 Asp333
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	Glu138 His445 Lys270 Asp346
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	6hr7(B,A) 6hr8(C,E,F,D,A,B)	Glu122 His422 Lys257 Asp332
1dqa(C,B,A,D) 1hwl(C,B,A,D) 1hwj(C,B,A,D) 1dq9(C,B,A,D) 1hwi(C,B,A,D) 1hw8(C,B,A,D) 1hwk(C,B,A,D) 1hw9(C,B,A,D) 1dq8(C,B,A,D)	2q1l(C,B,A,D) 3ccz(C,B,A,D) 3cda(C,B,A,D) 3bgl(C,B,A,D) 3cd7(C,B,A,D) 2r4f(C,B,A,D) 3ccw(C,B,A,D) 3cd0(C,B,A,D) 3cdb(C,B,A,D) 3cd5(C,B,A,D) 3cct(C,B,A,D) 2q6b(C,B,A,D) 2q6c(C,B,A,D)	Glu125 His432 Lys257 Asp333