M-CSA Mechanism and Catalytic Site Atlas

7-carboxy-7-deazaguanine synthase (M-CSA:943)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of A0A0H3KB22

Reference Sequence	Homologue	Cys49 Asp50 Phe25 Thr51 Cys31 Cys46 Glu116 His204
A0A0H3KB22	A0A0H3KB22	Cys49 Asp50 Phe25 Thr51 Cys31 Cys46 Glu116 His204
A0A0H3KB22	Q89SC0	Cys49 Asp50 Phe25 Thr51 Cys31 Cys46 Glu116 His204
A0A0H3KB22	P73667	Cys49 Asp50 Phe36 Gln51 Cys42 Cys46 Glu109 His202
A0A0H3KB22	Q2RSY6	Cys53 Asp54 Phe40 Thr55 Cys46 Cys50 Glu113 His229
A0A0H3KB22	Q9ZCV2	Cys62 Asp63 Phe49 Thr64 Cys55 Cys59 Glu126 His228
A0A0H3KB22	Q7NCE3	Cys52 Asp53 Phe39 Thr54 Cys45 Cys49 Glu112 His208
A0A0H3KB22	A6H1N2	Cys51 Asp52 Phe38 Val53 Cys44 Cys48 Glu110 His204
A0A0H3KB22	Q728E5	Cys49 Asp50 Phe25 Thr51 Cys31 Cys46 Glu119 His210
A0A0H3KB22	Q9K0Q5	Cys48 Asp49 Phe35 Thr50 Cys41 Cys45 Glu105 His206
A0A0H3KB22	Q7V9H9	Cys40 Asp41 Phe27 Thr42 Cys33 Cys37 Glu110 His219
A0A0H3KB22	P64554	Cys38 Asp39 Phe25 Thr40 Cys31 Cys35 Glu118 His217
A0A0H3KB22	P45097	Cys48 Asp49 Phe35 Thr50 Cys41 Cys45 Glu105 His205
A0A0H3KB22	Q9A3P3	Cys49 Asp50 Phe25 Thr51 Cys31 Cys46 Glu116 His204
A0A0H3KB22	Q89ZC3	Cys38 Asp39 Phe25 Thr40 Cys31 Cys35 Glu94 His176
A0A0H3KB22	Q7VVJ8	Cys49 Asp50 Phe25 Thr51 Cys31 Cys46 Glu116 His204
A0A0H3KB22	B0R9W6	Cys55 Asp56 Phe42 Ser57 Cys48 Cys52 Glu117 His247
A0A0H3KB22	Q8K9D9	Cys38 Asp39 Phe25 Thr40 Cys31 Cys35 Glu118 His213
A0A0H3KB22	P64555	Cys38 Asp39 Phe25 Thr40 Cys31 Cys35 Glu118 His217
A0A0H3KB22	P64556	Cys38 Asp39 Phe25 Thr40 Cys31 Cys35 Glu118 His217