M-CSA Mechanism and Catalytic Site Atlas

L-fuconate dehydratase (M-CSA:961)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 2hxt

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1ojy(h), 2y7m(f), 4bwp(g), 5juu(c), 5wve(d)

PDB sequences homologous to 2hxt

Reference PDB chains/ identical chains	Homologous PDB chains	Glu301A His351A Asp324A Asp248A Lys220A Glu274A
2hxt(A)	3mqt(U,M,K,P,S,O,G,V,A,C,E,B,W,T,N,H,R,I,Q,F,L,D,J,X)	Glu259 His309 Asp282 Asp206 Cys174 Glu233
2hxt(A)	3i6e(E,F,B,G,D,C,A,H)	Glu250 Gly300 Lys273 Asp198 Lys170 Glu224
2hxt(A)	3t8q(B,A)	Glu237 His287 Asp260 Asp185 Arg149 Glu211
2hxt(A)	2pgw(E,F,B,G,D,C,A,H)	Gln248 His298 Gly271 Asp196 Lys169 Glu222
2hxt(A)	3u4f(B,D,A,C)	Glu257 His307 Asp280 Asp205 Arg169 Glu231
2hxt(A)	2dw7(M,I,E,K,B,P,F,G,L,D,H,J,O,N,A,C)	Glu265 His322 Asp292 Asp213 Lys184 Glu239
2hxt(A)	4dwd(B,A) 3n4e(B,A)	Glu249 His298 Asp271 Asp197 Arg162 Glu223
2hxt(A)	2hxu(A)	Glu301 His351 Asp324 Asp248 Ala220 Glu274
2hxt(A)	4hcl(B,A) 4hch(B,A) 4hcd(A)	Glu278 His329 Gly302 Asp226 His191 Glu252
2hxt(A)	2poz(E,F,B,G,D,H,A,C)	Glu257 His307 Asp280 Asp205 Tyr159 Glu231
2hxt(A)	2p88(E,F,B,G,D,H,A,C) 2p8b(A) 2p8c(A)	Glu244 Gly294 Lys267 Asp191 Lys163 Glu218
2hxt(A)	2gge(E,F,B,G,D,H,A,C) 2gdq(B,A)	Glu243 His293 Asp266 Asp190 Lys161 Glu217
2hxt(A)	3ozy(B,A) 3ozm(E,F,B,G,D,H,A,C)	Glu254 His304 Asp277 Asp201 Lys173 Glu227
2hxt(A)	2oz3(E,F,B,G,D,H,A,C) 3ekg(B,A)	Glu270 His320 Asp293 Asp216 Pro181 Glu242
2hxt(A)	4h19(M,I,E,K,B,P,F,G,L,D,J,O,C,N,A,H) 3tj4(B,A)	Glu255 His305 Asp278 Asp203 Lys174 Glu229
2hxt(A)	2ox4(E,F,B,G,D,H,A,C)	Glu267 His317 Asp290 Glu215 Asp168 Glu241
2hxt(A)	4m6u(B,A) 4fp1(B,A) 3uxk(B,D,A,C) 4x2p(A) 3uxl(B,A,D,C) 6vim(E,F,B,G,D,H,A,C)	Glu271 His321 Asp294 Asp219 Lys190 Glu245
2hxt(A)	2pp3(B,A,C)	x x x x x x
2hxt(A)	3ugv(E,F,B,G,D,H,A,C)	Glu277 His327 Asp300 Asp225 Arg196 Glu251
2hxt(A)	4ip4(B,A) 4ip5(B,A)	Glu299 His349 Asp322 Asp246 Lys218 Glu272
2hxt(A)	3dfy(M,I,E,K,B,P,F,G,L,D,J,O,C,N,A,H) 2zad(B,D,A,C) 3des(B,A,D,C) 3deq(B,D,A,C) 3der(C,B,A,D)	Glu242 Gly291 Lys265 Asp188 Lys161 Glu216
2hxt(A)	3msy(E,F,B,D,A,C)	Gln251 His301 Asp274 Asp198 Lys169 Glu224
2hxt(A)	3cb3(B,A,D,C) 2og9(B,A)	Glu265 His315 Asp288 Asp213 Lys184 Glu239
2hxt(A)	5olc(E,F,B,G,D,H,A,C)	x x x x x x
2hxt(A)	1xs2(B,D,A,C) 1r0m(B,A,D,C) 1xpy(B,D,A,C)	Glu246 Gly296 Lys269 Asp195 Lys170 Glu220
2hxt(A)	3cyj(B,A,D,C)	Glu249 His297 Asp270 Asp194 Lys166 Glu221
2hxt(A)	5fjr(B,A,D,C) 5fju(B,A,D,C)	Glu240 Gly290 Lys263 Asp189 Lys163 Glu214
2hxt(A)	1mdr(A)	Glu247 His297 Asp270 Asp195 Lys166 Glu221
2hxt(A)	2ggj(B,D,A,C)	Glu246 Gly296 Lys269 Asp195 Lys170 Glu220
2hxt(A)	3ddm(B,D,A,C)	Glu258 His308 Asp281 Asp205 Lys177 Glu231
2hxt(A)	2pp0(B,A,C) 2pp1(E,F,B,D,A,C)	x x x x x x
2hxt(A)	2ggi(B,D,A,C)	Glu246 Gly296 Lys269 Asp195 Lys170 Glu220
2hxt(A)	4hpn(A) 4ggb(A)	Glu246 His296 Asp269 Asp194 Lys166 Glu220
2hxt(A)	4jn7(A) 4jn8(A)	Glu242 His292 Asp265 Asp189 Ser151 Glu216
2hxt(A)	3fxg(E,F,B,G,D,H,A,C)	Glu275 His325 Asp298 Asp222 Pro187 Glu248
2hxt(A)	4h83(E,F,B,D,A,C)	Gln268 His318 Asp291 Asp215 Lys186 Glu241
2hxt(A)	2fkp(B,D,A,C)	Glu246 Gly296 Lys269 Asp195 Lys170 Glu220
2hxt(A)	2zc8(B,A)	Glu239 Gly289 Lys262 Asp188 Lys163 Glu213
2hxt(A)	4kem(B,A)	Glu264 His321 Asp291 Asp212 Lys183 Glu238
2hxt(A)	1tzz(B,A)	Glu268 His325 Asp295 Asp216 Lys187 Glu242
2hxt(A)	3rcy(E,F,B,G,D,H,A,C)	Glu261 His311 Ala284 Gly209 Asp168 Glu235
2hxt(A)	1yey(B,D,A,C)	Glu304 His354 Asp327 Asp251 Lys223 Glu277
2hxt(A)	3go2(A) 3sn0(A) 3sn1(A) 3sn4(A) 2oo6(A)	Glu269 His318 Asp292 Asp219 Asn165 Glu245
2hxt(A)	3t4w(B,D,A,C)	Glu282 His332 Ala305 Gly230 Asp189 Glu256
2hxt(A)	3t9p(B,A)	Glu257 His307 Asp280 Asp205 Arg169 Glu231
2hxt(A)	3toy(B,A,D,C) 3tte(B,A)	Glu271 His321 Asp294 Asp219 Lys190 Glu245
2hxt(A)	1mdl(A)	Glu247 His297 Asp270 Asp195 Arg166 Glu221
2hxt(A)	3sjn(B,A)	Glu252 His302 Asp275 Asp199 Gly168 Glu226
2hxt(A)	2oqh(B,A,D,C)	Met247 His297 Asp270 Asp197 Lys170 Glu223
2hxt(A)	3op2(B,A) 3h12(B,A)	Glu254 His304 Asp277 Asp201 Lys173 Glu227
2hxt(A)	5xd9(A)	Glu250 Asn300 Asp273 Asp198 Lys169 Glu224
2hxt(A)	5xd8(B,A) 5xd7(A)	Glu250 His300 Asp273 Asp198 Lys169 Glu224
2hxt(A)	4a35(A)	Glu306 His356 Asp329 Asp251 Lys223 Glu277
2hxt(A)	2dw6(B,D,A,C)	Glu265 His322 Asp292 Asp213 Ala184 Glu239
2hxt(A)	2hxt(A)	x x x x x x
2hxt(A)	1rvk(A)	Glu258 His309 Gly282 Asp206 His171 Glu232
2hxt(A)	2mnr(A) 1mns(A)	Glu245 His295 Asp268 Asp193 Lys164 Glu219
2hxt(A)	4dx3(A) 4dxk(A)	Glu268 His318 Asp291 Glu216 Trp174 Glu242
2hxt(A)	2qq6(B,A)	Glu268 His318 Asp291 Asp216 Asp171 Glu242
2hxt(A)	2gl5(B,A)	Glu276 His326 Asp299 Glu224 Asp172 Glu250
2hxt(A)	3sqs(A)	Glu289 His339 Asp312 Glu237 Arg202 Glu263
2hxt(A)	3ssz(A)	Glu289 His339 Asp312 Glu237 Arg202 Glu263
2hxt(A)	4hnc(B,A)	Glu271 His321 Asp294 Asp219 Cys190 Glu245
2hxt(A)	3bjs(B,A)	Glu288 His338 Asp311 Asp235 Arg207 Glu261
2hxt(A)	1dtn(A)	Glu247 His297 Asp270 Asp195 Lys166 Glu221
2hxt(A)	3tcs(B,A)	Glu257 His307 Asp280 Asp205 Arg169 Glu231
2hxt(A)	4dye(A)	Met268 His318 Asp291 Asp218 Lys191 Glu244
2hxt(A)	2oz8(B,A)	Glu251 Gly296 His273 Asp196 Lys167 Glu224
2hxt(A)	4mmw(B,A)	Glu281 His332 Gly305 Asp229 His194 Glu255
2hxt(A)	4e4u(A)	Glu259 His309 Asn282 Gly207 Asp166 Glu233
2hxt(A)	1sjc(B,D,A,C) 1sjb(B,D,A,C) 1sjd(B,D,A,C) 1sja(B,D,A,C)	Glu240 Gly290 Lys263 Asp189 Lys163 Glu214
2hxt(A)	1tkk(E,F,B,G,D,C,A,H) 1jpm(B,D,A,C)	Glu245 Gly295 Lys268 Asp191 Lys162 Glu219
2hxt(A)	4j3z(E,F,B,G,D,C,A,H)	Glu261 His310 Ala283 Gly209 Asp168 Glu235
2hxt(A)	5fjt(B,A,D,C) 4a6g(B,A,D,C) 5fjo(B,A)	Glu240 Gly290 Lys263 Asp189 Lys163 Glu214
2hxt(A)	3q45(I,E,F,B,G,D,H,A,C) 3q4d(I,E,F,B,G,D,C,A,H)	Glu242 Gly292 Lys265 Asp190 Lys162 Glu216
2hxt(A)	3no1(E,F,B,D,A,C)	Gln270 His320 Asp293 Asp217 Lys188 Glu243
2hxt(A)	2ovl(B,A,D,C) 3ck5(B,D,A,C)	Glu249 His299 Asp272 Asp197 Lys168 Glu223
2hxt(A)	3k1g(E,F,B,G,D,C,A,H) 3jw7(E,F,B,G,D,C,A,H) 3jva(E,F,B,G,D,H,A,C) 3kum(E,F,B,G,D,C,A,H) 3jzu(E,F,B,G,D,C,A,H)	Glu241 Gly291 Lys264 Asp189 Lys161 Glu215
2hxt(A)	3rr1(B,A) 3rra(B,A)	Glu236 His286 Asp259 Asp184 Asn147 Glu210
2hxt(A)	4e5t(E,F,B,G,D,H,A,C)	Glu266 His316 Asn289 Gly214 Asp173 Glu240
2hxt(A)	5fjp(C,B,A,D)	Glu240 Gly290 Lys263 Asp189 Lys163 Glu214
2hxt(A)	2p0i(E,F,B,G,D,C,A,H)	Glu275 His325 Asp298 Asp222 Pro187 Glu248
2hxt(A)	4e6m(E,F,B,G,D,H,A,C)	Glu297 His347 Asp320 Glu245 Asp193 Glu271
2hxt(A)	3dip(B,A)	Glu272 His322 Asp295 Glu219 Trp178 Glu245
2hxt(A)	2ggg(B,D,A,C) 2ggh(B,D,A,C)	Glu246 Gly296 Lys269 Asp195 Lys170 Glu220
2hxt(A)	2hne(B,A,D,C)	Glu301 His351 Asp324 Asp248 Lys220 Glu274
2hxt(A)	1mra(A)	Glu247 His297 Asn270 Asp195 Lys166 Glu221
2hxt(A)	3stp(A)	Glu288 His338 Asp311 Glu236 Arg201 Glu262
2hxt(A)	2qde(E,F,B,G,D,H,A,C)	Glu247 Gly297 Lys270 Asp195 Lys167 Glu221