M-CSA Mechanism and Catalytic Site Atlas

Mannonate dehydratase (uxuA) (M-CSA:963)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 4eay

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

4eac(A, B, C, D)

PDB sequences homologous to 4eay

Reference PDB chains/ identical chains	Homologous PDB chains	His298(318)A Asp351(371)A His352(372)A Tyr368(388)A Cys271(291)A His233(253)A
4eay(C,B,A,D) 4eac(C,B,A,D)	6p5r(A)	x x x x x x
4eay(C,B,A,D) 4eac(C,B,A,D)	4eay(C,B,A,D) 4eac(C,B,A,D)	His318 Asp371 His372 Tyr388 Cys291 His253
4eay(C,B,A,D) 4eac(C,B,A,D)	3dbn(B,A) 3ban(B,A) 3fvm(B,A) 3bdk(B,A)	His286 Asp330 His331 Tyr345 Cys257 His219
4eay(C,B,A,D) 4eac(C,B,A,D)	1tz9(B,A)	His282 Asp327 His328 Tyr341 Cys255 His217
4eay(C,B,A,D) 4eac(C,B,A,D)	2khj(A)	not aligned not aligned not aligned not aligned not aligned not aligned
4eay(C,B,A,D) 4eac(C,B,A,D)	1x9a(B,A)	not aligned not aligned not aligned not aligned not aligned not aligned
4eay(C,B,A,D) 4eac(C,B,A,D)	6p5r(A)	x x x x x x
4eay(C,B,A,D) 4eac(C,B,A,D)	4eay(C,B,A,D) 4eac(C,B,A,D)	His318 Asp371 His372 Tyr388 Cys291 His253
4eay(C,B,A,D) 4eac(C,B,A,D)	3dbn(B,A) 3ban(B,A) 3fvm(B,A) 3bdk(B,A)	His286 Asp330 His331 Tyr345 Cys257 His219
4eay(C,B,A,D) 4eac(C,B,A,D)	1tz9(B,A)	His282 Asp327 His328 Tyr341 Cys255 His217
4eay(C,B,A,D) 4eac(C,B,A,D)	2khj(A)	not aligned not aligned not aligned not aligned not aligned not aligned
4eay(C,B,A,D) 4eac(C,B,A,D)	1x9a(B,A)	not aligned not aligned not aligned not aligned not aligned not aligned
4eay(C,B,A,D) 4eac(C,B,A,D)	6p5r(A)	x x x x x x
4eay(C,B,A,D) 4eac(C,B,A,D)	4eay(C,B,A,D) 4eac(C,B,A,D)	His318 Asp371 His372 Tyr388 Cys291 His253
4eay(C,B,A,D) 4eac(C,B,A,D)	3dbn(B,A) 3ban(B,A) 3fvm(B,A) 3bdk(B,A)	His286 Asp330 His331 Tyr345 Cys257 His219
4eay(C,B,A,D) 4eac(C,B,A,D)	1tz9(B,A)	His282 Asp327 His328 Tyr341 Cys255 His217
4eay(C,B,A,D) 4eac(C,B,A,D)	2khj(A)	not aligned not aligned not aligned not aligned not aligned not aligned
4eay(C,B,A,D) 4eac(C,B,A,D)	1x9a(B,A)	not aligned not aligned not aligned not aligned not aligned not aligned
4eay(C,B,A,D) 4eac(C,B,A,D)	6p5r(A)	x x x x x x
4eay(C,B,A,D) 4eac(C,B,A,D)	4eay(C,B,A,D) 4eac(C,B,A,D)	His318 Asp371 His372 Tyr388 Cys291 His253
4eay(C,B,A,D) 4eac(C,B,A,D)	3dbn(B,A) 3ban(B,A) 3fvm(B,A) 3bdk(B,A)	His286 Asp330 His331 Tyr345 Cys257 His219
4eay(C,B,A,D) 4eac(C,B,A,D)	1tz9(B,A)	His282 Asp327 His328 Tyr341 Cys255 His217
4eay(C,B,A,D) 4eac(C,B,A,D)	2khj(A)	not aligned not aligned not aligned not aligned not aligned not aligned
4eay(C,B,A,D) 4eac(C,B,A,D)	1x9a(B,A)	not aligned not aligned not aligned not aligned not aligned not aligned