Course at EMBL-EBI
Bioinformatics for T-Cell immunology
This course will introduce and explore a number of key bioinformatics tools and resources that can be applied to T-cell immunological research. Targeted at life scientists with a wet-lab focus, it will provide participants with an overview of best-practice methods in applying bioinformatics approaches and enable them to become confident users of their own and public domain data. The resources introduced during the course will cover a variety of data types, from genomic data to computational models, and biological pathways. Participants will gain experience of the analysis pipelines for RNA-Seq and flow cytometry experiments as well as data integration of -omics data and basics concepts of machine learning approaches.This course has been developed in collaboration with the ENLIGHT-TEN+ project, a consortium focused on developing early-stage research expertise in T-cell immunology and big data analysis.
In-person course
We plan to deliver this course in an in-person manner onsite at our training suite at EMBL-EBI, Hinxton. Please be aware that we are continually evaluating the ongoing pandemic situation and, as such, may need to change the format of courses at short notice. Your safety is paramount to us; you can read our COVID guidance policy for more information. All information is correct at time of publishing.
Who is this course for?
The course is aimed at wet-lab scientists working in the field of immunology who wish to learn more about available data and tools that can help them in their research.
15 places are reserved for early-stage researchers from the ENLIGHT-TEN+ project.
What will I learn?
Learning outcomes
- Locate and search bioinformatics resources for data of interest
- Utilise software and tools to manipulate and analyse immunology data
- Use experience in NGS workflows for analysis of ChIP-Seq and RNA-Seq datasets
- Apply bioinformatics methodologies to your own research
Course content
During this course you will learn about:
- Bioinformatics tools and resources for immunology
- Databases relevant to immunology research: Single cell Expression Atlas, Reactome, ENA, Omics Discovery Index (OmicsDI)
- scRNA-Seq data analysis
- Flow cytometry analysis
- Use cases on machine- and deep-learning
- Genetics of molecular and immune phenotypes
- FAIR data
Trainers
Cecilia Dominguez Conde
Sanger Institute, UK Artuur Couckuyt
Ghent University, Belgium Gaurhari Dass
EMBL-EBI Rasa Elmentaite
Sanger Institute, UK
EMBL-EBI Nancy George
EMBL-EBI Maira Ihsan
EMBL-EBI Matthew Hall
EMBL-EBI Tamás Korcsmáros
Imperial College London, UK Anna Lorenc
Sanger Institute, UK Matthew Madgwick
Earlham Institute, UK Maaly Nassar
SciBite Marta Perez Alcantara
Sanger Institute, UK Katrien Quintelier
Ghent University, Belgium Eliot Ragueneau
EMBL-EBI Dayane Rodrigues Araújo
EMBL-EBI Craig Russell
EMBL-EBI Blagoje Soskic
Human Technopole António Gonçalves de Sousa
Turku Centre for Biotechnology Jean-Christophe Lone
Instituto de Medicina Molecular João Lobo Antunes Elena Lukyanova
Sanger Institute, UK Dezső Módos
Quadram Institute
Programme
All timings are in BST.
Time Topic Trainer Day one - 11 July 12:00 - 13:00 Arrival, registration, and lunch 13:00 - 13:30 Welcome and introduction to EMBL-EBI Dayane Araújo 13:30 - 14:30 State-of-the-art in T-cell immunology Cecilia Dominguez Conde 14:30 - 15:30 Bioinformatics tools and resources for immunology Anna Lorenc 15:30 - 16:00 Networking break 16:00 - 18:00 R for immunology bioinformatics Anna Lorenc, Marta Perez Alcantara, Elena Lukyanova 18:00 End of day 19:30 Evening meal Day two - 12 July 08:45 - 09:00 Arrival and registration 09:00 - 10:00 ScRNAseq bioinformatics Cecilia Dominguez Conde and Rasa Elmentaite 10:00 - 10:30 Networking break 10:30 - 11:30 ScRNAseq bioinformatics Cecilia Dominguez Conde and Rasa Elmentaite 11:30 - 12:30 Expression Atlas Nancy George 12:30 - 13:30 Lunch break and poster session 13:30 - 15:30 Computational flow cytometry Artuur Couckuyt and Katrien Quintelier 15:30 - 16:00 Networking break 16:00 - 17:30 Handling cytometry data in R and quality control Artuur Couckuyt and Katrien Quintelier 17:30 - 18:30 Visualising cytometry data in R Artuur Couckuyt and Katrien Quintelier 18:30 - 19:00 Introducing group projects 19:30 Evening meal Day three - 13 July 08:45 - 09:00 Arrival 09:00 - 10:00 Multiple ways to integrate multi-omics data - case studies from studying human diseases Tamás Korcsmáros and Matthew Madgwick 10:00 - 10:30 Networking break 10:30 - 12:30 Practical session on integration of -omics data Tamás Korcsmáros, Matthew Madgwick and Dezső Módos 12:30 - 13:30 Lunch break and poster session 13:30 - 14:45 Multi-omics pathway analyses for immunologic research (Reactome GSA) Eliot Ragueneau 14:45 - 15:30 Machine and deep learning for image data Craig Russell 15:30 - 16:00 Networking break 16:00 - 17:00 Machine and deep learning for biosynthetic gene clusters (BGCs) discovery Maaly Nassar 17:00 - 18:30 Group project António Gonçalves de Sousa and Jean-Christophe Lone 18:30 - 19:00 Networking 19:30 Evening meal Day four - 14 July 08:45 - 09:00 Arrival 09:00 - 10:00 OmicsDI Gaurhari Dass 10:00 - 10:30 Networking break 10:30 - 12:30 Genetics of molecular and immune phenotypes Blagoje Soskic 12:30 - 13:30 Lunch break 13:30 - 14:30 High-throughput sequencing: Material sharing, dissemination, and reusability Maira Ihsan 14:30 - 15:30 Open data and entrepreneurship - a contradiction? Matt Hall 15:30 - 16:00 Networking break 16:00 - 18:30 Group project António Gonçalves de Sousa and Jean-Christophe Lone 18:30 - 19:00 Drinks reception 19:30 Evening meal Day five - 15 July 08:45 - 09:00 Arrival 09:00 - 10:00 Group project António Gonçalves de Sousa and Jean-Christophe Lone 10:00 - 10:30 Networking break 10:30 - 11:30 Group project presentation 11:30 - 12:30 Lunch break and group photo 12:30 - 13:30 Final discussion 13:30 - 14:00 Closing remarks Dayane Araújo 14:00 End of course
Programme may be subject to slight changes before registration.
Please read our page on application advice before starting your application. In order to be considered for a place on this course, you must do the following:
- Complete the online application form.
- Ensure you add relevant information to the "application submission" section where you are asked to provide information on your:
- scientific biography
- work history
- current research interests
- Upload a letter of support from your supervisor or a senior colleague detailing reasons why you should be selected for the course.
Please submit all documents during the application process by midnight on 18 March. Items marked * are in the application are mandatory. Incomplete registrations will not be processed.
All applicants will be informed of the status of their application (successful, waiting list, rejected) by 1 April. If you have any questions regarding the application process please contact Sophie Spencer.
Note that the registration fee includes:
- All meals (breakfast, lunch, dinner and refreshment breaks)
- Accommodation for four nights
- Course materials
- Use of a computer in the EMBL-EBI training room throughout the course
Accommodated will be provided onsite at the Hinxton Hall Conference Centre. Please contact them directly if you wish to arrange to stay additional nights around the course dates.
The course includes evening meals, as well as breaks and lunches outside the EMBL-EBI training rooms.
Sanger Institute, UK
Ghent University, Belgium
EMBL-EBI
Sanger Institute, UK
EMBL-EBI
EMBL-EBI
EMBL-EBI
EMBL-EBI
Imperial College London, UK
Sanger Institute, UK
Earlham Institute, UK
SciBite
Sanger Institute, UK
Ghent University, Belgium
EMBL-EBI
EMBL-EBI
EMBL-EBI
Human Technopole
Turku Centre for Biotechnology
Instituto de Medicina Molecular João Lobo Antunes
Sanger Institute, UK
Quadram Institute
Programme
All timings are in BST.
Time | Topic | Trainer |
Day one - 11 July | ||
12:00 - 13:00 | Arrival, registration, and lunch | |
13:00 - 13:30 | Welcome and introduction to EMBL-EBI | Dayane Araújo |
13:30 - 14:30 | State-of-the-art in T-cell immunology | Cecilia Dominguez Conde |
14:30 - 15:30 | Bioinformatics tools and resources for immunology | Anna Lorenc |
15:30 - 16:00 | Networking break | |
16:00 - 18:00 | R for immunology bioinformatics | Anna Lorenc, Marta Perez Alcantara, Elena Lukyanova |
18:00 | End of day | |
19:30 | Evening meal | |
Day two - 12 July | ||
08:45 - 09:00 | Arrival and registration | |
09:00 - 10:00 | ScRNAseq bioinformatics | Cecilia Dominguez Conde and Rasa Elmentaite |
10:00 - 10:30 | Networking break | |
10:30 - 11:30 | ScRNAseq bioinformatics | Cecilia Dominguez Conde and Rasa Elmentaite |
11:30 - 12:30 | Expression Atlas | Nancy George |
12:30 - 13:30 | Lunch break and poster session | |
13:30 - 15:30 | Computational flow cytometry | Artuur Couckuyt and Katrien Quintelier |
15:30 - 16:00 | Networking break | |
16:00 - 17:30 | Handling cytometry data in R and quality control | Artuur Couckuyt and Katrien Quintelier |
17:30 - 18:30 | Visualising cytometry data in R | Artuur Couckuyt and Katrien Quintelier |
18:30 - 19:00 | Introducing group projects | |
19:30 | Evening meal | |
Day three - 13 July | ||
08:45 - 09:00 | Arrival | |
09:00 - 10:00 | Multiple ways to integrate multi-omics data - case studies from studying human diseases | Tamás Korcsmáros and Matthew Madgwick |
10:00 - 10:30 | Networking break | |
10:30 - 12:30 | Practical session on integration of -omics data | Tamás Korcsmáros, Matthew Madgwick and Dezső Módos |
12:30 - 13:30 | Lunch break and poster session | |
13:30 - 14:45 | Multi-omics pathway analyses for immunologic research (Reactome GSA) | Eliot Ragueneau |
14:45 - 15:30 | Machine and deep learning for image data | Craig Russell |
15:30 - 16:00 | Networking break | |
16:00 - 17:00 | Machine and deep learning for biosynthetic gene clusters (BGCs) discovery | Maaly Nassar |
17:00 - 18:30 | Group project | António Gonçalves de Sousa and Jean-Christophe Lone |
18:30 - 19:00 | Networking | |
19:30 | Evening meal | |
Day four - 14 July | ||
08:45 - 09:00 | Arrival | |
09:00 - 10:00 | OmicsDI | Gaurhari Dass |
10:00 - 10:30 | Networking break | |
10:30 - 12:30 | Genetics of molecular and immune phenotypes | Blagoje Soskic |
12:30 - 13:30 | Lunch break | |
13:30 - 14:30 | High-throughput sequencing: Material sharing, dissemination, and reusability | Maira Ihsan |
14:30 - 15:30 | Open data and entrepreneurship - a contradiction? | Matt Hall |
15:30 - 16:00 | Networking break | |
16:00 - 18:30 | Group project | António Gonçalves de Sousa and Jean-Christophe Lone |
18:30 - 19:00 | Drinks reception | |
19:30 | Evening meal | |
Day five - 15 July | ||
08:45 - 09:00 | Arrival | |
09:00 - 10:00 | Group project | António Gonçalves de Sousa and Jean-Christophe Lone |
10:00 - 10:30 | Networking break | |
10:30 - 11:30 | Group project presentation | |
11:30 - 12:30 | Lunch break and group photo | |
12:30 - 13:30 | Final discussion | |
13:30 - 14:00 | Closing remarks | Dayane Araújo |
14:00 | End of course |
Programme may be subject to slight changes before registration.
Please read our page on application advice before starting your application. In order to be considered for a place on this course, you must do the following:
- Complete the online application form.
- Ensure you add relevant information to the "application submission" section where you are asked to provide information on your:
- scientific biography
- work history
- current research interests
- Upload a letter of support from your supervisor or a senior colleague detailing reasons why you should be selected for the course.
Please submit all documents during the application process by midnight on 18 March. Items marked * are in the application are mandatory. Incomplete registrations will not be processed.
All applicants will be informed of the status of their application (successful, waiting list, rejected) by 1 April. If you have any questions regarding the application process please contact Sophie Spencer.
Note that the registration fee includes:
- All meals (breakfast, lunch, dinner and refreshment breaks)
- Accommodation for four nights
- Course materials
- Use of a computer in the EMBL-EBI training room throughout the course
Accommodated will be provided onsite at the Hinxton Hall Conference Centre. Please contact them directly if you wish to arrange to stay additional nights around the course dates.
The course includes evening meals, as well as breaks and lunches outside the EMBL-EBI training rooms.