Relationships between InterPro entries

InterPro entries often share relationships with other entries in the database. For example, an entry might represent a functionally-specific subfamily of a larger family, or a subclass belonging to a broad class of domains. These relationships are stored in InterPro as hierarchies, which are displayed as trees in the relationship section of an entry page (Figure 7). 

Both family and domain entries are able to form hierarchical relationships, although family and domain hierarchies are kept separate in the database and do not overlap (for example, a subclass of a particular domain can not be a subtype of a protein family). However, an exception is made for the relationship between homologous superfamily with family and domain entries; it is generated automatically using the Jaccard and containment indexes. This relation appears in the Overlapping homologous superfamilies section (Figure 7). Repeats and sites are not arranged into hierarchical relationships.

For more information on the Homologous superfamily entry type in InterPro, have a look at our Genome3D annotations in InterPro tutorial.