Searching with a member database signature

By searching for a member database signature using the text search, then clicking on the signature identifier in the search results or by clicking on the signature identifier in the protein sequence viewer, you’ll be redirected to the InterPro member database signature page.

The member database signature page (Figure 22) contains information about the member database providing the signature, the signature type, its short name, full name, a description and references if available. If a description giving information about the family/domain or site function is not provided by the member database and the signature is integrated in an InterPro entry, the InterPro description is displayed. On the right, a link to the member database website is available under the ‘External links‘ section. If the signature is integrated in an InterPro entry, the entry is displayed under the ‘Integrated to‘ section.

The side menu varies depending on the data available for each signature. It contains at least the ‘Proteins‘ (proteins matching the signature), ‘Taxonomy‘ (list of species the signature matches) and ‘Proteomes‘ (reference proteomes) tabs.

Additional links that are displayed only when the data is available include ‘Domain architectures‘ (different domains arrangements found for proteins matching the signature), ‘Structures‘ (PDB structures matching the signature), ‘AlphaFold‘ (AlphaFold structure predictions matching the signature), ‘Signature‘ (residue conservation hmm logo), ‘Alignment‘ (Pfam SEED and full proteins alignment) and ‘Curation‘ (Pfam curation information) as shown in Figure 23.