- Course overview
- Search within this course
- Protein-protein interactions
- Where do the data come from?
- Interaction databases
- Molecular interaction databases at EMBL-EBI
- Quiz: test your knowledge
- Summary
- Your feedback
- Learn more
- References
All materials are free cultural works licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, except where further licensing details are provided.
References
- Licata L. et al., Mint, the molecular interaction database: 2012 update. Nucleic Acids Res. 2012, Jan; 40: D857-61
- Kerrien S. et al., The IntAct molecular interaction database in 2012. Nucl. Acids Res. 2012, Jan; 40: D841-46
- Koh G.C. et al. Analyzing protein-protein interaction networks. J. Proteome Res. 2012 Apr; 11 (4): 2014-31
- Venkatesan K. et al., An empirical framework for binary interactome mapping. Nat Methods. 2009 Jan; 6 (1): 83-90
- Phizicky E.M. Fields S., Protein-protein interactions: methods for detection and analysis. Microbiol Rev. 1995 Mar; 59 (1): 94-123. Review
- Lalonde S. et al., Molecular and cellular approaches for the detection of protein-protein interactions: latest techniques and current limitations. Plant J. Feb; 53 (4): 610–635
- Brucker A. et al. Yeast two-two hybrid, a powerful tool for systems biology. Int. J. Mol. Sci. 2009 Jun; 10 (6): 2763-88
- Rigaut G. et al., A generic protein purification method for protein complex characterization and proteome exploration. Nat. Biotechnol. 1999, Oct; 17 (10): 1030-1032
- Bauer A. at al., Affinity purification-mass spectrometry. Powerful tools for the characterization of protein complexes. Eur. J. Biochem. 2003, Feb; 270 (4): 570-578
- Pflieger D. et al., Linking the proteins–elucidation of proteome-scale networks using mass spectrometry. Mass Spec. Rev. 2011, Mar-Apr; 30 (2): 268-297
- Kleiger G. et al., Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell. 2009, Nov; 139 (5): 957-68
- Petschnigg J. et al., Interactive proteomics research technologies: recent applications and advances. Curr. Opin. Biotechnol. 2011, Feb; 22 (1): 50-58
- De Las Rivas J. et al., Protein-protein interactions essentials: key concepts to building and analyzing interactome networks. PLoS Comput. Biol. 2010, Jun; 6 (6): e1000807
- Chautard E. et al., MatrixDB, a database focused on extracellular protein-protein and protein-carbohydrate interactions. Bioinformatics. 2009, Mar; 25 (5): 690–91
- Hernandez-Toro J. et al., APID2NET: unified interactome graphic analyzer. Bioinformatics. 2007, Sep; 23 (18): 2495-7
- Wu J. et al., Integrated network analysis platform for protein-protein interactions. Nat. Methods. 2009, Jan; 6 (1): 75-7
- Szklarczyk D. et al., The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucl. Acids Res. 2011, Jan; 39: D561-8
- Brown K.R. and Jurisica I., Online predicted human interaction database. Bioinformatics. 2005, May; 21 (9): 2076-82
- Orchard S. et al., The minimum information required for reporting a molecular interaction experiment (MIMIx). Nature Biotechnol. 2007, Aug; 25 (8): 894–898
- Orchard S. et al., Protein interaction data curation: the International Molecular Exchange (IMEx) consortium. Nat. Methods. 2012, Apr; 9 (4): 345–50