- Course overview
- Search within this course
- Why do we need a pathway database?
- What is Reactome?
- When to use Reactome
- Who is Reactome for?
- Navigating Reactome
- Understanding the Pathway Browser
- Analysing data
- Programmatic access
- Contributing to Reactome
- Summary
- Try it yourself!
- Your feedback
- Get help and support on Reactome
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Summary
- Reactome is a curated database that represents human pathways as interconnected molecular events or ‘reactions’
- Reactome broadly defines a reaction as any molecular event in biology, including binding, phosphorylation, catalysed biochemical events, spontaneous molecular events and transport
- Reactions can be considered as ‘steps’ in a pathway. Pathways are represented as diagrams containing a series of interconnected events, often organised into sub-pathways
- Reactome has a hierarchical organization, from ‘top-level’ broad topics in biology to lower-level specific pathways and the events they contain.
- The core dataset of human pathways is authored by expert biologists and independently peer-reviewed before release
- Reactome’s curated human events are used as templates to computationally infer equivalent pathways in other species, including the most widely used model organisms
- Reactions have literature citations that experimentally verify the described event
- Reactome uses primary external sources, and extensively cross-references many other relevant sources of biological, chemical and literature information
- Reactome hosts a range of pathway analysis tools that can be used to analyse experimental data and compare species/tissues
- External protein interaction data (default IntAct) can be overlaid on Reactome pathways for extended analysis
- Reactome data and software are open source, freely available to download and reuse from the website with appropriate citation