- Course overview
- Search within this course
- What is UniProt?
- Where does the data come from?
- Why do we need UniProt?
- When to use UniProt
- Quiz: Check your learning I
- How to access and navigate UniProt
- How to search UniProt
- Annotation score
- Quiz: Check your learning II
- Exploring a UniProtKB entry
- How to use UniProt tools
- How to get data from UniProt
- How to submit data to UniProt
- When to use UniProt: guided example
- Exercise: finding entries with 3D structures
- Exercise: mapping other database identifiers to UniProt
- Summary
- Your feedback
- Get help and support on UniProt
- References
Annotation score
What is the annotation score?
The annotation score provides a measure of the annotation content of a UniProtKB entry or proteome. It is a 5-point heuristic scoring system where a score of 5 is associated with the best-annotated entries, and a score of 1 with entries with basic annotation.
Where can I find the annotation score?
The annotation score of an entry can be found in the summary line at the top of each entry (Figure 20).
![](https://www.ebi.ac.uk/training/online/courses/uniprot-exploring-protein-sequence-and-functional-info/wp-content/uploads/sites/100/2022/07/Screenshot-2022-07-27-at-12.24.54-1024x100.png)
Adding annotation scores to search results
You can add annotation scores to your search results table through the ‘Columns’ button (Figure 21). When this is checked a ‘Customize columns’ box will open and you can select additional fields to display on the Table view.
![](https://www.ebi.ac.uk/training/online/courses/uniprot-exploring-protein-sequence-and-functional-info/wp-content/uploads/sites/100/2022/07/Fig-21.png)
How are annotation scores used?
There are several contexts in which annotation scores can be used:
- UniProtKB – the annotation scores can help you to get a quick idea of the relative level of annotation of the entries in your search results
- UniRef – UniProt uses annotation scores to select the representative member of a UniRef cluster
- Reference proteomes – UniProt uses annotation scores to assist with the selection of reference proteomes
How are annotation scores calculated?
- Different UniProtKB annotation types are scored either by presence or by number of occurrences. Annotations with experimental evidence score more highly than equivalent predicted annotations, thereby favouring expert literature-based curation over automatic annotation.
- The score of an individual entry is the sum of the scores of its annotations.