{"metadata":{"accession":"PF20302","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046873","hierarchy":null,"name":{"name":"HisK-N-like globin domain of the ASK signalosome","short":"HisK-N-like"},"description":[{"text":"<p>Predicted non-heme-binding version of the Globin domain identified in ASK signalosome. Displays strongest affinities to the HisK-N family of sensor domains, which inhibit histidine kinase activation required for sporulation in bacteria of the firmicutes lineage. This globin domain is predicted to represent an independent sensory element recognizing a fatty acid or a related membrane-derived molecule which regulates activity of the ASK signalosome in apoptosis [[cite:PUB00097693]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097693":{"PMID":32868406,"ISBN":null,"volume":"202","issue":"24","year":2020,"title":"Identification of Uncharacterized Components of Prokaryotic Immune Systems and Their Diverse Eukaryotic Reformulations.","URL":null,"raw_pages":null,"medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Burroughs AM","Aravind L."],"DOI_URL":null}},"set_info":{"accession":"CL0090","name":"Globin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":69,"interactions":0,"matches":4339,"pathways":0,"proteins":4305,"proteomes":930,"sets":1,"structural_models":{"alphafold":1258},"structures":0,"taxa":3670},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":2990},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}