The Electron Microscopy Data Bank (EMDB) is a public repository for cryogenic-sample Electron Microscopy (cryoEM) volumes and representative tomograms of macromolecular complexes and subcellular structures. It covers a variety of techniques, including single-particle analysis, helical reconstruction, electron tomography, subtomogram averaging, and electron crystallography. More...
As of 18 February 2026, EMDB contains 54491 entries (latest entries, trends).
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Q-score as a reliability measure for protein, nucleic acid and small-molecule atomic coordinate models derived from 3DEM maps
Grigore Pintilie, Chenghua Shao, Zhe Wang, Brian P Hudson, Justin W Flatt, Michael F Schmid, Kyle L Morris, Stephen K Burley, Wah Chiu. (2025) Acta Cryst D81: 410-422 doi: 10.1107/S2059798325005923
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In situ cryo-ET tomogram of lysosomes in E64d pre-treated (20uM, 30min) and LLOMe (0.5mM, 60min) treated TMEM192-3xHA HeLa cell.
In situ cryo-ET of lysosome damaged by LLOMe (0.5mM, 60min) encapsulated in an autophagosome in HeLa TMEM192-3xHA cell.
In situ cryo-ET tomogram of a lysosomal structure in untreated HeLa TMEM192-3xHA cell.
In situ cryo-ET tomogram of lysosomal structure in untreated rat hippocampal neurons
In situ cryo-ET tomogram of lysosomes in LLOMe (0.5mM, 60min) treated TMEM192-3xHA HeLa cell.
In situ cryo-ET tomogram of lysosome damaged by LLOMe (0.5mM, 60min) in HeLa TMEM192-3xHA cell.
Cryo-EM structure of PWWP domain deleted DNMT 3A2/3B3 in complex with a di-nucleosome
Amino-terminal domain for GluK2-0xNeto2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Consensus map for GluK2-0xNeto2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
H5 hemagglutinin (A/Jiangsu/NJ210/2023) in complex with central stem-targeting Fab ST14
H1 hemagglutinin (A/California/04/2009) with E47K mutation in HA2 in complex with central stem-targeting Fab ST10
Nanotube of computationally designed peptide assembly R3K (16 protofilament)
Amino-terminal domain for GluK2-2xNeto2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
H1 hemagglutinin (A/Michigan/45/2015) in complex with anchor-targeting Fab ST4
H1 hemagglutinin (A/Michigan/45/2015) in complex with anchor-targeting Fab ST15
Ligand-binding and transmembrane domains for GluK2-1xNeto2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Ligand-binding and transmembrane domains for GluK2-0xNeto2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Ligand-binding and transmembrane domains for GluK2-2xNeto2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Consensus map for GluK2-1xNeto2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Consensus map for GluK2-2xNeto2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Amino-terminal domain for GluK2-1xNeto2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Structure of naked mole-rat ribosome with P/E tRNA and eEF2 (rotated)
Negative stained A. vinelandii NifEN/NifH ADPxAIF4- stabilized complex
Cryo-EM structure of the LH1 complex from Roseiflexus castenholzii
Strand displacement state III of Human mitochondrial DNA polymerase gamma ternary complex
Strand displacement state II of Human mitochondrial DNA polymerase gamma ternary complex
Strand displacement state IV of Human mitochondrial DNA polymerase gamma ternary complex
Strand displacement state I of Human mitochondrial DNA polymerase gamma ternary complex
The ER membrane protein complex acts as a chaperone to promote voltage-gated calcium channel assembly
Cryo-EM structure of EF-G and RaiA simultaneously bound to an E. coli ribosome imaged in a cell lysate
Native GABA-A receptor from rat cerebella, beta2-alpha1-beta2-alpha1-gamma2 subtype, in complex with GABA
Native GABA-A receptor from rat cerebella, beta2-alpha1-beta1-alpha6-gamma2 subtype, in complex with GABA
Native GABA-A receptor from rat cerebella, beta1-alpha1-beta2-alpha1-gamma2 subtype, in complex with GABA and PZ-II-029
Native GABA-A receptor from rat cerebella, beta2-alpha1-beta1-alpha6-gamma2 subtype, in complex with GABA and PZ-II-029
Native GABA-A receptor from rat cerebella, beta1-alpha1-beta1-alpha1-gamma2 subtype, in complex with GABA and PZ-II-029
Native GABA-A receptor from rat cerebella, beta2-alpha1-beta2-alpha1-gamma2 subtype, in complex with GABA and PZ-II-029
Native GABA-A receptor from rat cerebella, beta1-alpha1-beta2-alpha1-gamma2 subtype, in complex with GABA
In situ structure of the human mitoribosome in the P-E state from TACO1-knockout cells
In situ structure of the human mitoribosome in the A-P state with TACO1
In situ structure of the human mitoribosome in the A-P-E state with TACO1
TLP-2g, a glycofibril obtained from a Karst cave from Guilin City, Guangxi Zhuang Autonomous Region, China
TLP-2a, a glycofibril obtained from a Karst cave from Guilin City, Guangxi Zhuang Autonomous Region, China
TLP-2h, a glycofibril obtained from a Karst cave from Guilin City, Guangxi Zhuang Autonomous Region, China
Pilus-like-alpha, a bacteria pilus-like structure obtained from a Karst cave from Guilin City, Guangxi Zhuang Autonomous Region, China
pilus-like-beta, a bacteria pilus-like structure obtained from a Karst cave from Guilin City, Guangxi Zhuang Autonomous Region, China
Cryo-EM map of SKM-70S ribosomal stalled complex in the major state (vacant A-site, canon)
Cryo-EM structure of SKM-70S ribosomal stalled complex in the A-tRNA positioned (Body open) state.
Cryo-EM structure of SKM-70S ribosomal stalled complex in the rotated state with hybrid tRNAs
Human 80S ribosome in complex with NatA in proximal and distal position
Human 80S ribosome in complex with NatA in distal position and Ebp1
A membrane protein with cofactor determined by single-particle CryoEM
Amino-terminal domain for GluK2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to a di-nucleosome with a five base pair linker
A focus of tetramer (2) of the cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome
Cryo-EM structure a single nucleosome (2) focus of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome
Cryo-EM structure of DNMT 3A2/3B3 tetramer in complex with a di-nucleosome with a six base pair linker
Ligand-binding and transmembrane domains for GluK2-0xNeto2 in the apo state with asymmetric ligand binding domain
Cryo-EM structure of DNMT 3A2/3B3 tetramer in complex with a di-nucleosome with K120R mutant H2B
A focus of DNMT tetramer (1) of the cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome
Amino-terminal domain for GluK2-0xNeto2 in the apo state with asymmetric ligand binding domain
Ligand-binding and transmembrane domains for GluK2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Cryo-EM structure of a di-nucleosome with an eight base-pair linker
The consensus model of the cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome
Cryo-EM structure of a single nucleosome (1) focus of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome
Cryo-EM structure of a di-nucleosome with a five base pair linker
Cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to a di-nucleosome and an histone-3 peptide
Consensus map for GluK2 in the open state, in complex with the positive allosteric modulator BPAM344 and agonist kainate
Cryo-EM structure of RNase P in cell lysates determined using the graffendor grid
Focus map of DNMT3A2/3B3 tetramer for Cryo-EM structure of DNMT3A2/3B3 in complex with 167H3K36me2-nucleosome
Consensus map for GluK2-0xNeto2 in the apo state with asymmetric ligand-binding domain
Focus map of nucleosome for Cryo-EM structure of DNMT3A2/3B3 in complex with 167H3K36me2-nucleosome
Cryo-EM structure of SUDV glycoprotein with modified HR1c (L579P) and HR2 stalk bound to CA45 Fab
Consensus map for Cryo-EM structure of DNMT3A2/3B3 tetramer in complex with a 167H3K36me2 nucleosome
cryoEM structure of RNase MRP in yeast cell lysates using the Graffendor grid.
Focus map of nucleosome 2 for Cryo-EM structure of DNMT3A2/3B3 in complex with H3K36me2 di-nucleosome with eight base pair linker
Focus map of PWWP_2 for Cryo-EM structure of DNMT3A2/3B3 in complex with 167H3K36me2-nucleosome
CryoEM structure of capsid from human astrovirus 1 in complex with human neonatal Fc receptor
Consensus map for Cryo-EM structure of DNMT3A2/3B3 in complex with H3K36me2 di-nucleosome with eight-base-pair linker
Focus map of nucleosome 1 for Cryo-EM structure of DNMT3A2/3B3 in complex with H3K36me2 di-nucleosome with eight base pair linker
Focus map of PWWP_1 domain for Cryo-EM structure of DNMT3A2/3B3 in complex with 167H3K36me2-nucleosome
Focus map of nucleosome1_PWWP1 for Cryo-EM structure of DNMT3A2/3B3 in complex with H3K36me2 di-nucleosome with eight base pair linker
Focus map of DNMT3A2/3B3 tetramer2 for Cryo-EM structure of DNMT3A2/3B3 in complex with H3K36me2 di-nucleosome with eight base pair linker
Focus map of DNMT3A2/3B3 tetramer1 for Cryo-EM structure of DNMT3A2/3B3 in complex with H3K36me2 di-nucleosome with eight base pair linker
CryoEM structure of human astrovirus 1 spike in complex with human neonatal Fc receptor
native NMDA receptor-GluN1/N2B/NX in the open state consensus map
native NMDA receptor-GluN1/N2B/NX in inactive state consensus map
native NMDA receptor-GluN1/N2A/N2B in inactive state consensus map
native NMDA receptor-GluN1/N2B/NX in the open state TMD focused map
native native NMDA receptor-GluN1/N2B in inactive state TMD focused map
native NMDA receptor-GluN1/N2B in the inactive state consensus map
native NMDA receptor-GluN1/N2B/NX in inactive state TMD focused map
native NMDA receptor-GluN1/N2A/N2B in inactive state TMD focused map
pilus-like-gamma, a bacteria pilus-Like structure obtained from a Karstcave from Guilin city, Guangxi ZhuangAutonomous Region, China
TLP-2f, a glycofibril obtained from a Karst cave from Guilin City, Guangxi Zhuang Autonomous Region, China
Subtomogram average of the Chlamydomonas reinhardtii chlororibosome - chimeric map
Structure of Oceanobacillus iheyensis group II intron domains D1-D6
Structure of the Chlamydomonas reinhardtii chlororibosome with P-site tRNA - consensus map
Subtomogram average of the Chlamydomonas reinhardtii chlororibosome - SSU extension focused
Structure of the Chlamydomonas reinhardtii chlororibosome - SSU head extension recenter and focus
Structure of the Chlamydomonas reinhardtii chlororibosome - SSU head focus
Structure of the Chlamydomonas reinhardtii chlororibosome - SSU extension focus
Structure of the Chlamydomonas reinhardtii chlororibosome - LSU focus
Structure of the Chlamydomonas reinhardtii chlororibosome - LSU L7/12 stalk focus
Subtomogram average of the membrane-bound Chlamydomonas reinhardtii chlororibosome
Structure of the Chlamydomonas reinhardtii chlororibosome - LSU CP focus
Structure of the Chlamydomonas reinhardtii chlororibosome - SSU body focus
Structure of the Chlamydomonas reinhardtii chlororibosome with pY factor - LSU focus
Subtomogram average of the Chlamydomonas reinhardtii chlororibosome - LSU focused
Structure of the Chlamydomonas reinhardtii chlororibosome with P-site tRNA - LSU focus
Subtomogram average of the Chlamydomonas reinhardtii chlororibosome - SSU focused
Structure of the Chlamydomonas reinhardtii chlororibosome with pY factor - consensus map
Structure of the Chlamydomonas reinhardtii chlororibosome - consensus map
Subtomogram average of the Chlamydomonas reinhardtii chlororibosome - consensus map
Structure of the Chlamydomonas reinhardtii chlororibosome with pY factor - focus SSU
Structure of the Chlamydomonas reinhardtii chlororibosome with P-site tRNA - focus SSU
Cas9 in complex with tracrRNA and crRNA, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Cas9-Cas1-Cas2-Csn2 supercomplex with dsDNA in PAM-unbound conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
PAM-bound Cas9-Cas1-Cas2-Csn2 supercomplex in the locked conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Csn2 (point mutations Y212R, I213R and M215R) in complex with Cas1-Cas2 integrase and dsDNA, Streptococcus thermophilus DGCC 7710 CRISPR3 system
PAM-bound Cas9-Cas1-Cas2-Csn2 supercomplex in the docked conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
PAM-bound Cas9-Cas1-Cas2-Csn2 supercomplex in the docked conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
PAM-bound Cas9-Cas1-Cas2-Csn2 supercomplex in the locked conformation, Streptococcus thermophilus DGCC 7710 (consensus map)
Cas9-Cas1-Cas2-Csn2 supercomplex with dsDNA in PAM-unbound conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Cas9-Cas1-Cas2-Csn2 supercomplex with dsDNA in PAM-unbound conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Cas9:crRNA:tracrRNA in complex with PAM-containing non-cognate DNA, PAM-bound conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
PAM-bound Cas9-Cas1-Cas2-Csn2 supercomplex in the docked conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Cas1-Cas2 CRISPR integrase bound to prespacer and target DNA, Streptococcus thermophilus DGCC 7710 CRISPR3 system
PAM-bound Cas9-Cas1-Cas2-Csn2 supercomplex in the locked conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
PAM-bound Cas9-Cas1-Cas2-Csn2 supercomplex in the locked conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Cas9-Cas1-Cas2-Csn2 supercomplex with dsDNA in PAM-unbound conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Cas9:crRNA:tracrRNA in complex with PAM-containing non-cognate DNA, PAM-unbound conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Partial Cas1-Cas2 CRISPR integrase complex bound to a half-integration product, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Cas1-Cas2 CRISPR integrase bound to prespacer DNA, Streptococcus thermophilus DGCC 7710 CRISPR3 system
PAM-bound Cas9-Cas1-Cas2-Csn2 supercomplex in the docked conformation, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Cryo-EM structure of ternary complex BCL6-CRBN-DDB1 with BMS-986458 (local refined), a potent and selective BCL6 ligand directed degrader (LDD)
Cryo-EM structure of apo GPR50 with BRIL fusion, anti-BRIL Fab, and anti-Fab Nb complex
Composite map for Cryo-EM structure of DNMT3A2-DNMT3B3 tetramer bound to 167H3K36me2-nucleosome
Cryo-EM structure of DNMT3A2/3B3 in complex with H3K36me2 di-nucleosome with eight base pair linker
KICSTOR-GATOR1 complex (SZT2 [2800-3432], C12orf66) focused refinement
In situ structure of human mitoribosome in the A/T-P state from TACO1-knockout cells
In situ structure of the human mitoribosome in the P state from TACO1-knockout cells
KICSTOR-GATOR1 complex (SZT2 [2000-3200], KPTN, ITFG2) focused refinement
In Situ Structure of the Human Mitochondrial Large Subunit 39S in Complex with TACO1
In Situ Structure of the Human Mitoribosome Large Subunit 39S in Complex with EF-Tu
KICSTOR-GATOR1 dimer supercomplex (SZT2, NPRL2, NPRL3) focused refinement
In situ structure of the human mitoribosome in the A-P state from TACO1-knockout cells
In situ structure of the human mitoribosome in the A/P-P/E state from TACO1-knockout cells
In situ structure of the human mitoribosome in the A/T-P-E state from TACO1-knockout cells
In situ structure of the human mitoribosome in the A-P-E state from TACO1-knockout cells
EAAT1 thermostabilized mutant in Complex with L-Asp, Metal Ions, and the allosteric inhibitor UCPH101 in Salipro
Glutamate transporter homologue GltPh mutant P206R in Complex with L-Aspartate and Sodium Ions in Salipro
Cryo-electron tomogram of cryo-FIB milled Nostoc PCC7120 wild-type
EAAT1 thermostabilized mutant in Complex with Rubidium, and the allosteric inhibitor UCPH101 in DDS/CHS
Inward-open structure of human GABA transporter 3 bound to selective inhibitor SR-THAP
Pre-activated 9-subunit COP9 signalosome and neddylated SCF (Skp1-Skp2-Cks1) complex structure
Dissociation-state-2 of 9-subunit CSN and SCF (SKP1-SKP2-CKS1) complex
Dissociation-state-1 of 9-subunit CSN and SCF (SKP1-SKP2-CKS1) complex
Type I-F_HNH variant Cascade target-free RNP, HNH domain in outwards position
Type I-F_HNH variant Cascade bound to dsDNA, HNH domain in inwards position
Type I-F_HNH variant Cascade bound to dsDNA, HNH domain in outwards position
Type I-F_HNH variant Cascade bound to dsDNA, HNH domain in middle position
Type I-F_HNH variant Cascade bound to dsDNA, HNH domain in inwards position
Type I-F_HNH variant Cascade bound to dsDNA, HNH domain in outwards position
NMT1-NAC bound human RNC with 58 amino acid ARF1-linker - State 1
NMT1-NAC bound human RNC with full length ARF1 - alternative State
NMT1-NAC bound human RNC with 58 amino acid ARF1-linker - State 2
Cryo-EM structure of E coli pstSCAB in the catalytic intermediate state
Cryo-EM structure of E coli pstSCAB in the pretranslocation state
Structure of compacted DNA-free MCM DH at 3.9 Angstroms resolution
CryoEM map of recombinant human MCM SH with MCM3 I804A/F806A/I808A
Structure of extended DNA-free MCM DH at 3.8 Angstroms resolution
The structure of NCP-motor-ARP module of ncBAF-nucleosome complex
Cryo-EM structure of BTN2A1-BTN3A1-BTN3A2 mutant (BTN3A1 H381R, BTN2A1 R477A/T510A) in complex with Vgamma9-Vdelta2 TCR (G115 genotype)
Structure of the honeybee GABAA RDL receptor with GABA and Abamectin
Structure of bacteriophage T4 protal-neck protein gp20-gp13-gp14-Hfq assembled in vitro in C6 symmetry
Structure of bacteriophage T4 neck protein gp13 and gp14 and Hfq assembled in vitro in C6 symmetry
Structure of bacteriophage T4 neck protein gp13 and gp14 assembled in vitro in C6 symmetry
Structure of bacteriophage T4 protal-neck mismatch complex gp20-gp14-gp13 assembled in vitro in C6 symmetry
Complex structure of influenza hemagglutinin HA stem with CR9114 Fab and FISW84 Fab
Cryo-EM structure of dopamine bound mut-beta2-Adrenergic Receptor beta2R-M16-miniGs-Gbeta1gamma2-Nb35-scFv16 complex
Cryo-EM structure of epinephrine bound dopamine receptor 1 D1R-M74-miniGs-Gbeta1gamma2-Nb35 complex
Cryo-EM Structure of Human Tie2/minibinder tw1102_4 helices Complex
Glycogen phosphorylase from Segatella copri bound to glycogen-chain A and E
Cryo-EM structure of glycogen phosphorylase from Dorea longicatena (monomer form)
Cryo-EM structure of glycogen phosphorylase from Dorea longicatena (dimer form)
Glycogen phosphorylase from Segatella copri decamer in complex with AMP
Glycogen phosphorylase dimer from E. coli in complex with glycogen
Glycogen phosphorylase from Segatella copri bound to glycogen-pentamer
A focused Cryo_EM structure of LA_PTH_PTH1R_Beta_arrestin1 complex(state 1 conformation)
A Cryo_EM structure of LA_PTH_PTH1R_Beta_arrestin1 complex(state 2 conformation)
Cryo-EM map of glycogen phosphorylase from Dorea longicatena (monomer form with extra density)
R583A mutant of glycogen phosphorylase from Segatella copri in the presence of AMP
Glycogen phosphorylase from Segatella copri pentamer in complex with AMP chains D and E
In situ cryo-ET tomogram of lysosomes in BAPTA AM pre-treated (50uM, 30min) and LLOMe (0.5mM, 60min) treated TMEM192-3xHA HeLa cell.
In situ cryo-ET tomogram of lysosomal structure in LLOMe-treated (0.5mM, 1h) rat hippocampal neuron.