The Electron Microscopy Data Bank (EMDB) is a public repository for cryogenic-sample Electron Microscopy (cryoEM) volumes and representative tomograms of macromolecular complexes and subcellular structures. It covers a variety of techniques, including single-particle analysis, helical reconstruction, electron tomography, subtomogram averaging, and electron crystallography. More...
As of 16 September 2026, EMDB contains 61993 entries (latest entries, trends).
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New tools support deposition of structures to the wwPDB directly from structure determination software packages.
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All EMBL-EBI data resources together lead to an estimated £11.8bn/year in research productivity gains. These data also drive developments in technologies like AlphaFold, cryoSPARC and modelAngelo. We are privileged to be part of that. Read about the report and case studies here >
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Publication: Chart builder: an interactive tool for user driven data visualization in the electron microscopy data bank. Fonseca N et al. (2026) Front. Bioinform. doi: 10.3389/fbinf.2026.1763403
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Ribosome-Sec translocon-Dome supercomplex in chloramphenicol treated Mycoplasma pneumoniae cells by K2 camera
Ribosome-Sec translocon-Dome supercomplex in native untreated Mycoplasma pneumoniae cells
Ribosome-Sec translocon-Dome supercomplex in spectinomycin treated Mycoplasma pneumoniae cells
Focus map of chains A and B of the bacterial antiviral defense protein PD-T7-3 (H122A) in complex with single-stranded DNA and a fragment of RNA
Subtomogram average of the C. thermophilum 80S ribosome - rotated pre-translocating state
Cryo-EM structure of mouse myeloperoxidase in complex with Fab fragments of antibodies mAb-A46 and mAb-B88
Cryo-EM structure of mouse myeloperoxidase in complex with Fab fragments of antibodies mAb-A24 and mAb-A46
Focus map of chains A and B of the bacterial antiviral defense protein PD-T7-3 (H122A) in a complex with a fragment of RNA
Pentameric complex of serine proteinase (SDH) with hypothetical protein (HP)
Hexameric complex of serine proteinase(SDH) with hypothetical protein(HP)
Heptameric complex of serine proteinase(SDH) with hypothetical protein(HP)
Undecameric complex of serine proteinase (SDH) with hypothetical protein (HP)
Bacterial antiviral defense protein PD-T7-3 (H122A) in complex with single-stranded DNA and a fragment of RNA
Human PRC1.4 in complex with native UBCH5C bound to a H3Kc27me3 mononucleosome
Bacterial antiviral defense protein PD-T7-3 (H122A) in complex with single-stranded DNA
Subtomogram average of the C. thermophilum 80S ribosome - post-translocating state
Cryo-EM structure of the orphan receptor GPRC5D in ligand free state resolved via the fusion/crosslinking strategy
The in situ structure of adjacent conoid fibers from Toxoplasma gondii tachyzoite
Cryo-EM structure of the human glucagon receptor (GCGR) in ligand free state resolved via the fusion/crosslinking strategy
Tetramer Msp1 from S.cerevisiae (with a catalytic dead mutation) in complex with an unknown peptide substrate
CryoEM structure of monoclonal Fab 047-09M 2F03 binding the lateral patch of influenza virus H1 HA (A/California/04/2009)
Coagulation factor V DTQQ (B-domain region 811-1491 truncated, R709Q, R1545Q) in solution-phase
CryoEM Structure of human MDA5 disease-linked mutant T331I with dsRNA (one protein subunit on dsRNA)
Coagulation factor VIII, full-length, membrane-bound, on Ptd-choline : Ptd-serine 75:25 vesicles
Coagulation factor V DTQQ, membrane-bound, on Ptd-choline : Ptd-serine 75:25 vesicles
Ribosome-Sec translocon-Dome supercomplex in puseudoridimycin treated Mycoplasma pneumoniae cells
Open conformation dome complex including the Sec-translocon (SecYEG-SecA-SecDF) from untreated Mycoplasma pneumoniae cell
Consensus map of the bacterial antiviral defense protein PD-T7-3 (H122A) in complex with single-stranded DNA
CryoEM map of human MDA5 T331I mutant filament formed on short dsRNA
Focus map of chain C of the bacterial antiviral defense protein PD-T7-3
VIPR Ternary Complex with a pre-unwound dsDNA substrate, 11 subunits
VIPR Ternary Complex with an ssRNA substrate, Closed Conformation, 11 subunits
VIPR Ternary Complex with a pre-unwound dsDNA substrate, 12 subunits
Subtomogram average of the C. thermophilum 80S ribosome - decoding state
Open conformation dome complex including the Sec-translocon (SecYEG-SecDF) from untreated Mycoplasma pneumoniae cells
Subtomogram average of the C. thermophilum 80S ribosome - translocating state
V-shaped (channel-formed), ATP-bound, VX809-bound conformation of wild-type human CFTR (composite map from PHENIX based on consensus and local refinement maps from cryoSPARC)
Cryo-EM structure of PI(3,5)P2-bound full-length mouse TRPML2 channel in lipid nanodisc II
Cryo-EM structure of ML-SA1-bound full-length mouse TRPML2 channel in lipid nanodisc, closed II
Cryo-EM structure of ML-SA1-bound full-length mouse TRPML2 channel in lipid nanodisc, closed I
Cryo-EM structure of ML-SA1-bound full-length mouse TRPML2 channel in lipid nanodisc, closed III
Shigella flexneri type III secretion system (T3SS) protein IpaD bound to hemolysis blocking Fab D02-F2 and hemolysis enhancing Fab D02-E4
Shigella flexneri type III secretion system (T3SS) protein IpaD bound to hemolysis blocking antibody fragment D13r-34
Cryo-EM structure of PI(3,5)P2 and ML-SA1 bound full-length mouse TRPML2 channel in lipid nanodisc, closed I
Cryo-EM structure of ML-SA1-bound full-length mouse TRPML2 channel in lipid nanodisc, closed IV
Consensus map of the bacterial antiviral defense protein PD-T7-3 (H122A) in complex with single-stranded DNA and a fragment of RNA
A consensus Cryo_EM structure of PACAP27_PAC1R_Beta_arrestin 1 complex
Cryo EM structure of SARS-COV-2 (BA.4) RBD in complex with THZ937 Fab (local refine)
A focused Cryo_EM structure of PAC1R of PACAP27_PAC1R_Beta_arrestin 1 complex
A focused Cryo_EM structure of Arrestin of PACAP27_PAC1R_Beta_arrestin 1 complex
Subtomogram average of the C. thermophilum 80S ribosome - eIF5a bound
local refinement of 5HT2BR-fab heterotrimer in complex with a novel antagonist IHCH-2330
local refinement of 5HT2AR-miniGq heterotrimer in complex with a selective agonist IHCH-2330
local reifnement of 5HT2AR-miniGq heterotrimer in complex with a psychedelic psilocin
Structure of the HCoV-229E spike glycoprotein determined by subtomogram averaging
Cryo-EM structure of ARAF-MEK1 complex with GDC-0879 and a covalent MEK inhibitor TWG-07-148
Cryo-EM structure of the human PRMT5:MEP50:pICln complex at a 4:4:4 stoichiometric ratio
Cryo-EM structure of the human PRMT5:MEP50:pICln complex at a 4:3:4 stoichiometric ratio
Cryo-EM structure of an intact human acetylcholinesterase (T-form) tetramer in complex with ColQ
Cryo-EM structure of an intact human acetylcholinesterase (T-form) tetramer in complex with PRiMA
Cryo-EM structure of pyruvate dehydrogenase from Mycobacterium tuberculosis
Cryo-EM structure of the dihydrolipoamide dehydrogenase complexed with the binding domain of the dihydrolipoyl transacetylase from Mycobacterium tuberculosis pyruvate dehydrogenase complex
Cryo-EM structure of the dihydrolipoamide dehydrogenase complexed with the lipoyllysine and binding domain of the dihydrolipoyl transacetylase from Mycobacterium smegmatis pyruvate dehydrogenase complex
Focus map of chains A and B of the bacterial antiviral defense protein PD-T7-3
T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor IID432
Open conformation dome complex including the Sec-translocon (SecYEG-SecA-SecDF) with inward-facing SecDF and substrate from untreated Mycoplasma pneumoniae cells
Open conformation dome complex including the Sec-translocon (SecYEG-SecA-SecDF) with inward-facing SecDF from untreated Mycoplasma pneumoniae cells
Subtomogram average of the C. thermophilum 80S ribosome - hibernating state
In-situ structure of the Shigella injectisome from spa47 K165A mutant
Subtomogram average of the C. thermophilum 80S ribosome - unrotated pre-translocating state
In-situ structure of the Shigella injectisome from spa33 F70D mutant
In-situ structure of the Shigella injectisome from spa33 F67A/F70A mutant
In-situ structure of the Shigella injectisome from spa33 F219D/Y221A mutant
In-situ structure of the Shigella injectisome from mxiK L46D mutant
Focused map of corner subparticles of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions; Corner mask)
Focused map of rabbit RyR1 RY12 domain complexed with ADP and Mg2+
Focused map of rabbit RyR1 complexed with FKBP12.6, calmodulin, ATP, and 4-chloro-m-cresol (Core-Pore mask)
Consensus map of rabbit RyR1 complexed with FKBP12.6, calmodulin, ATP, and 4-chloro-m-cresol
Multibody refinement of pooled Ribosome-Sec translocon-Dome supercomplexes from four antibiotic treated Mycoplasma pneumoniae datasets, body 1/3
Focused map of corner subparticles of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (Corner mask)
Focused map of rabbit RyR1 complexed with FKBP12.6, calmodulin, ATP, and 4-chloro-m-cresol (BSol mask)
Focused map of corner subparticles of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (Corner mask)
Focused map of rabbit RyR1 complexed with FKBP12.6, calmodulin, ATP, and 4-chloro-m-cresol (NSol mask)
Consensus map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+ (NSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (BSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (NSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+ (BSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+ (JSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (Core-Pore mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+ (Core-Pore mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (JSol mask)
Consensus map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ADP, 4-chloro-m-cresol, caffeine, and Mg2+
Consensus map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ADP, 4-chloro-m-cresol, caffeine, and Mg2+
Focused map of rabbit RyR1 complexed with FKBP12.6, calmodulin, ATP, and 4-chloro-m-cresol (JSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking muscle fatigue; JSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking muscle fatigue) (NSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (BSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (NSol mask)
Consensus map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking muscle fatigue)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (Core-Pore mask)
Focused map of corner subparticles of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking muscle fatigue; Corner mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (JSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking muscle fatigue; BSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions; NSol mask)
Consensus map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking muscle fatigue; Core-Pore mask)
Focused map of RY12 domain of rabbit RyR1 in the presence of dantrolene and Mg2+ (open RY12 conformation)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions; BSol mask)
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions; JSol mask)
Structure of RY12 domain of rabbit RyR1 complexed with ADP and Mg2+ (mimicking physiological conditions; bound and closed RY12)
Consensus map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene and Mg2+
Consensus map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, Mg2+, and Ca2+
Structure of RY12 domain of rabbit RyR1 complexed with ARM210 and ATP
Structure of RY12 domain of rabbit RyR1 in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions; unbound and open RY12)
Focused map of RY12 domain of rabbit RyR1 complexed with ADP and Mg2+ (mimicking muscle fatigue)
Focused map of corner subparticles of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, 4-chloro-m-cresol, and caffeine (Corner mask)
Structure of RY12 domain of rabbit RyR1 in the presence of ATP, Mg2+, and Ca2+ (open RY12 conformation)
Consensus map of rabbit RyR1 complexed with FKBP12 and calmodulin in the presence of ARM210, ATP, caffeine, and Ca2+
Structure of RY12 domain of rabbit RyR1 complexed with dantrolene and ATP
Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions; Core-Pore mask)
Focused map of corner subparticles of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+ (Corner mask)
Structure of RY12 domain of rabbit RyR1 complexed with ATP and 4-chloro-m-cresol
Structure of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions)
Structure of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+
Structure of rabbit RyR1 complexed with FKBP12.6, calmodulin, ADP, 4-chloro-m-cresol, caffeine, and Mg2+
Structure of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ADP, 4-chloro-m-cresol, caffeine, and Mg2+
Structure of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking muscle fatigue)
Structure of RY12 domain of rabbit RyR1 complexed with dantrolene and ADP
Structure of rabbit RyR1 complexed with FKBP12.6, calmodulin, ATP, 4-chloro-m-cresol, and caffeine
Cryo-EM structure of L-lysine 6-dehydrogenase complex with NAD+ and L-lysine
Cryo-EM structure of the outwardly rectifying potassium channel TOK1 from Saccharomyces cerevisiae in a lipid nanodisc
5-HT2AR bound to LSD in complex with mini-Gq and scFv16 obtained by cryo-electron microscopy (cryoEM)
5-HT2AR bound to IHCH-1906 obtained by cryo-electron microscopy (cryoEM)
Cryo-EM structure of the R323A mutant (ICD-ordered class) of the outwardly rectifying potassium channel TOK1 from Saccharomyces cerevisiae
Cryo-EM structure of the R323A mutant (ICD-disordered class) of the outwardly rectifying potassium channel TOK1 from Saccharomyces cerevisiae
Cryo-EM structure of canonical human nucleosome in the presence of 1 mM magnesium chloride
Cryo-EM structure of the T322I mutant of the outwardly rectifying potassium channel TOK1 from Saccharomyces cerevisiae
5-HT2AR bound to IHCH-6122 in complex with mini-Gq and scFv16 obtained by cryo-electron microscopy (cryoEM)
5-HT2AR bound to IHCH-1904 in complex with mini-Gq and scFv16 obtained by cryo-electron microscopy (cryoEM)
5-HT2B receptor bound to IHCH-6122 in complex with an antibody obtained by cryo-electron microscopy (cryoEM)
5-HT2B receptor bound to IHCH-1906 in complex with an antibody obtained by cryo-electron microscopy (cryoEM)
Cryo-EM structure of glutamine synthetase 2 from Mycobacterium tuberculosis
Cryo-EM structure of glutamine synthetase 3 from Mycobacterium tuberculosis
Cryo-EM structure of glutamine synthetase 4 from Mycobacterium tuberculosis
Cryo-EM structure of the Bavachalcone bound GPR120-Giq complex (local refinement)
CryoEM structure of SufR from Mycobacterium tuberculosis bound to the promoter of the suf operon
Cryo-EM structure of cariprazine-bound D3 dopamine receptor with mini-Go
Bacterial antiviral defense protein PD-T7-3 (H122A) in complex with a fragment of RNA
Focus map of chain C of the bacterial antiviral defense protein PD-T7-3 (H122A) in complex with a fragment of RNA
Bacterial antiviral defense protein PD-T7-3 (82-84 residues deleted) obtained from a sample containing single-stranded DNA and tRNA
Bacterial antiviral defense protein PD-T7-3 obtained from a sample containing single-stranded DNA and tRNA
Multibody refinement of pooled Ribosome-Sec translocon-Dome supercomplexes from four antibiotic treated Mycoplasma pneumoniae datasets, body 2/3
Multibody refinement of pooled Ribosome-Sec translocon-Dome supercomplexes from four antibiotic treated Mycoplasma pneumoniae datasets, body 3/3
Ribosome-Sec translocon-Dome supercomplex in chloramphenicol treated Mycoplasma pneumoniae cells imaged on K3 camera
CryoEM structure of nucleoside diphosphate kinase (NDK) from Streptococcus pneumoniae
Focus map of chains A and B of the bacterial antiviral defense protein PD-T7-3 (H122A) in complex with single-stranded DNA
Closed conformation dome complex including the Sec-translocon in the minor SecA conformation (SecYEG-SecA-SecDF) in untreated Mycoplasma pneumoniae cells
Consensus map of the bacterial antiviral defense protein PD-T7-3 (H122A) in complex with a fragment of RNA
Focus map of chain C of the bacterial antiviral defense protein PD-T7-3 (H122A) in complex with single-stranded DNA
Focus map of chain C of the bacterial antiviral defense protein PD-T7-3 (H122A) in complex with single-stranded DNA and a fragment of RNA