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EMD-43932
Activated CRAF/MEK heterotetramer from focused refinement of CRAF/MEK/14-3-3 complex
EMD-43932
Single-particle4.16 Å
Deposition: 06/03/2024Map released: 17/04/2024
Last modified: 17/04/2024
Sample Organism:
Homo sapiens
Sample: Activated CRAF/MEK1 heterotetramer complex from focused refinement
Fitted models: 9axc
Deposition Authors: Quade B
,
Cohen SE ,
Huang X
Sample: Activated CRAF/MEK1 heterotetramer complex from focused refinement
Fitted models: 9axc
Deposition Authors: Quade B
,
Cohen SE ,
Huang X
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers.
Ryan MB ,
Quade B ,
Schenk N ,
Fang Z ,
Zingg M ,
Cohen SE ,
Swalm BM ,
Li C ,
Ozen A ,
Ye C ,
Ritorto MS ,
Huang X ,
Dar AC ,
Han Y ,
Hoeflich KP ,
Hale M ,
Hagel M
(2024) Cancer Discov
,
Quade B ,
Schenk N ,
Fang Z ,
Zingg M ,
Cohen SE ,
Swalm BM ,
Li C ,
Ozen A ,
Ye C ,
Ritorto MS ,
Huang X ,
Dar AC ,
Han Y ,
Hoeflich KP ,
Hale M ,
Hagel M
(2024) Cancer Discov