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Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- At118-h nanobody, type-1 angiotensin ii receptor, soluble cytochrome b562 complex (65 kDa, Protein from Homo sapiens)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- At118-h nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion, anti-bril fab, and anti-fab nanobody (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8th4
Q-score: 0.495
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- [2-butyl-5-chloranyl-3-[[4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol (422 Da, Ligand)
- Type-1 angiotensin ii receptor soluble cytochrome b562 complex (49 kDa, Protein from Homo sapiens)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- At118-l nanobody (15 kDa, Protein from synthetic construct)
- At118-l nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion protein, anti-bril fab, anti-fab nanobody, and losartan (Complex from Homo sapiens)
Structural mechanism of inhibition of the Rho transcription termination factor by Rof
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w8d
Q-score: 0.452
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8gk7
Q-score: 0.364
Wang H, Ishchenko A, Skudlarek J, Shen P, Dzhekieva L, Painter RE, Chen YT, Bukhtiyarova M, Leithead A, Tracy R, Babaoglu K, Bahnck-Teets C, Buevich A, Cabalu TD, Labroli M, Lange H, Lei Y, Li W, Liu J, Mann PA, Meng T, Mitchell HJ, Mulhearn J, Scapin G, Sha D, Shaw AW, Si Q, Tong L, Wu C, Wu Z, Xiao JC, Xu M, Zhang LK, McKenney D, Miller RR, Black TA, Cooke A, Balibar CJ, Klein DJ, Raheem I, Walker SS
Nat Microbiol (2024) 9 pp. 1244-1255 [ DOI: doi:10.1038/s41564-024-01667-0 Pubmed: 38649414 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Lipid a export atp-binding/permease protein msba (66 kDa, Protein from Acinetobacter baumannii)
- Msba complexed with cerastecin c (450 kDa, Complex from Acinetobacter baumannii)
- 2-[(4-butylbenzene-1-sulfonyl)amino]-5-[(3-{4-[(4-butylbenzene-1-sulfonyl)amino]-3-carboxyanilino}-3-oxopropyl)carbamoyl]benzoic acid (778 Da, Ligand)
Cryo-EM structure of ochratoxin A-detoxifying amidohydrolase ADH3
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8ihq
Q-score: 0.632
Dai L, Niu D, Huang JW, Li X, Shen P, Li H, Xie Z, Min J, Hu Y, Yang Y, Guo RT, Chen CC
J Hazard Mater (2023) 458 pp. 131836-131836 [ Pubmed: 37331057 DOI: doi:10.1016/j.jhazmat.2023.131836 ]
- Adh3 (Complex from Stenotrophomonas acidaminiphila)
- Zinc ion (65 Da, Ligand)
- Amidohydrolase family protein (45 kDa, Protein from Stenotrophomonas acidaminiphila)
Cryo-EM structure of ochratoxin A-detoxifying amidohydrolase ADH3 in complex with Phe
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8ihr
Q-score: 0.666
Dai L, Niu D, Huang JW, Li X, Shen P, Li H, Xie Z, Min J, Hu Y, Yang Y, Guo RT, Chen CC
J Hazard Mater (2023) 458 pp. 131836-131836 [ Pubmed: 37331057 DOI: doi:10.1016/j.jhazmat.2023.131836 ]
- Adh3 (Complex from Stenotrophomonas acidaminiphila)
- Phenylalanine (165 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Amidohydrolase family protein (45 kDa, Protein from Stenotrophomonas acidaminiphila)
Cryo-EM structure of ochratoxin A-detoxifying amidohydrolase ADH3 in complex with ochratoxin A
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8ihs
Q-score: 0.645
Dai L, Niu D, Huang JW, Li X, Shen P, Li H, Xie Z, Min J, Hu Y, Yang Y, Guo RT, Chen CC
J Hazard Mater (2023) 458 pp. 131836-131836 [ Pubmed: 37331057 DOI: doi:10.1016/j.jhazmat.2023.131836 ]
- Adh3 (Complex from Stenotrophomonas acidaminiphila)
- Amidohydrolase family protein (45 kDa, Protein from Stenotrophomonas acidaminiphila)
- Zinc ion (65 Da, Ligand)
- (2~{s})-2-[[(3~{r})-5-chloranyl-3-methyl-8-oxidanyl-1-oxidanylidene-3,4-dihydroisochromen-7-yl]carbonylamino]-3-phenyl-propanoic acid (403 Da, Ligand)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j85
Q-score: 0.568
Dai L, Niu D, Huang JW, Li X, Shen P, Li H, Xie Z, Min J, Hu Y, Yang Y, Guo RT, Chen CC
J Hazard Mater (2023) 458 pp. 131836-131836 [ Pubmed: 37331057 DOI: doi:10.1016/j.jhazmat.2023.131836 ]
- Adh3 (Complex from Stenotrophomonas acidaminiphila)
- Zinc ion (65 Da, Ligand)
- Amidohydrolase family protein (45 kDa, Protein from Stenotrophomonas acidaminiphila)
- (2~{s})-2-[[(3~{r})-5-chloranyl-3-methyl-8-oxidanyl-1-oxidanylidene-3,4-dihydroisochromen-7-yl]carbonylamino]-3-phenyl-propanoic acid (403 Da, Ligand)
Monroe N, Shen P, Han H, Sundquist WI, Hill CP
To Be Published
- Vps2p (Protein from Saccharomyces cerevisiae)
- Vta1p (Protein from Saccharomyces cerevisiae)
- Vps4-vta1 complex (Complex from Saccharomyces cerevisiae)
- Vps4 (Protein from Saccharomyces cerevisiae)
Monroe N, Shen P, Han H, Sundquist WI, Hill CP
To Be Published
- Vps4p (Protein from Saccharomyces cerevisiae)
- Vps2p (Protein from Saccharomyces cerevisiae)
- Vps4-vta1 complex (Complex from Saccharomyces cerevisiae)
- Vta1p (Protein from Saccharomyces cerevisiae)