ENSG00000077327 (SPAG6)

homo sapiens

sperm associated antigen 6

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Homo sapiens
Organism part
Showing 53 experiments:
Created with Highcharts 6.2.0adiposebasal ganglioncerebellumduodenumforebrainhindbrain without cerebellumlivermonocytepancreasprostate glandsigmoid colonsubmandibular glandtibial arteryvas deferensanterior cingulate cortexbrain meninxcortex of kidneyepididymisgallbladderlarge intestinemedulla oblongatanucleus accumbenspituitary glandretinasmooth muscletestistricuspid valve
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68 FANTOM5 project - adult
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - 9 post …
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19 NIH Epigenomics Roadmap
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GTEX - organism part
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HDBR developing brain - 12 post …
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68 FANTOM5 project - fetal
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - Late 8 post …
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HDBR developing brain - 10 post …
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HDBR developing brain - 11 post …
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32 Uhlen's Lab
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HDBR developing brain - 16 post …
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HDBR developing brain - 13 post …
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Hallstrom et al., 2014 - Organism part
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Illumina Body Map
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - 14 post …
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Mammalian Kaessmann
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - Carnegie Stage …
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ENCODE (M. Snyder lab)
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Zhu et al., 2018 - Organism part
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - 15 post …
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Human2021_Tissues - Wang et al. 2019
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McKetney et al., 2019 – organism part …
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McKetney et al., 2019 – organism part …
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Human Proteome Map - adult
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McKetney J et.al., 2019 - Individual - …
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McKetney J et.al., 2019 - Individual - …
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McKetney J et.al., 2019 - Individual - …
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McKetney J et.al., 2019 - Individual - …
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Proteomics
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Transcriptomics
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Experimental variables
Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
6.0855 × 10-177.5
SPAG6'trichostatin A; 500 nanomolar' vs 'control'compoundTranscription profiling by high throughput sequencing of human aortic endothelial cell treated with TSA
Adjusted p-valueLog2-fold change
4.9731 × 10-197
SPAG6'suberoylanilide hydroxamic acid' vs 'control'compoundVascular histone deacetylation by pharmacological HDAC inhibition [SAHA, RNA-seq]
Adjusted p-valueLog2-fold change
4.9866 × 10-446.2
SPAG6'progenitor cell of endocrine pancreas' vs 'definitive endoderm cell' in 'GATA6 R456C/+; Patient A"cell line, cell type, genotype, individualRNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development
Adjusted p-valueLog2-fold change
1.1091 × 10-146
SPAG6'valproic acid; 15 millimolar' vs 'control' at '2 day'compound, sampling time pointRNA-seq of Primary Human Hepatocytes (PHH) exposed to Valproic Acid (VPA) for 3 days daily and 3 days daily exposure followed by 3 days washout.
Adjusted p-valueLog2-fold change
1.2354 × 10-135.7
SPAG6'valproic acid; 15 millimolar' vs 'control' at '3 day'compound, sampling time pointRNA-seq of Primary Human Hepatocytes (PHH) exposed to Valproic Acid (VPA) for 3 days daily and 3 days daily exposure followed by 3 days washout.
Adjusted p-valueLog2-fold change
7.8798 × 10-245.6
SPAG6'posterior fossa group B ependymoma' vs 'normal'diseaseGene expression profile of pediatric and adult brain tumor types and normal brain
Adjusted p-valueLog2-fold change
4.3092 × 10-55.6
SPAG6'apical radial glial cell' vs 'neuron'cell typeTranscription profiling by high throughput sequencing of the developing human cortex
Adjusted p-valueLog2-fold change
4.028 × 10-3-5.6
SPAG6'gestational week 11 to 13' vs 'adult' in 'normal'developmental stage, phenotypeComparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents
Adjusted p-valueLog2-fold change
2.5376 × 10-7-4.8
SPAG6'ejaculatory azoospermia; Johnsen score count 2' vs 'normal; Johnsen score count 10'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
1.9509 × 10-10-4.7
SPAG6'ejaculatory azoospermia; Johnsen score count 3.2' vs 'normal; Johnsen score count 10'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
1.2612 × 10-94.7
SPAG6'valproic acid; 15 millimolar' vs 'control' at '1 day'compound, sampling time pointRNA-seq of Primary Human Hepatocytes (PHH) exposed to Valproic Acid (VPA) for 3 days daily and 3 days daily exposure followed by 3 days washout.
Adjusted p-valueLog2-fold change
2.2392 × 10-64.7
SPAG6'poly(I:C); 25 microgram per milliliter' vs 'none' in 'none; none'compound, infect, stimulusRNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C.
Adjusted p-valueLog2-fold change
3.695 × 10-174.5
SPAG6'posterior fossa group A ependymoma' vs 'normal'diseaseGene expression profile of pediatric and adult brain tumor types and normal brain
Adjusted p-valueLog2-fold change
3.7904 × 10-15-4.3
SPAG6'breast carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
3.517 × 10-4-4.3
SPAG6'Mycobacterium tuberculosis' vs 'none' in 'infant'developmental stage, infectMultifaceted dysfunction of infant airway macrophages in response to Mycobacterium tuberculosis
Adjusted p-valueLog2-fold change
9.0674 × 10-104.2
SPAG6'ependymoma' vs 'normal'diseaseExpression data from human brain tumors and human normal brain
Adjusted p-valueLog2-fold change
1.0209 × 10-14-4.1
SPAG6'colorectal carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
2.49 × 10-74.1
SPAG6'supratentorial ependymoma' vs 'normal'diseaseGene expression profile of pediatric and adult brain tumor types and normal brain
Adjusted p-valueLog2-fold change
3.5341 × 10-44.1
SPAG6'28 day' vs '0 day'timeTranscription profiling of human airway epithelial cells cultured at an air-liquid interface (ALI) and sampled at multiple time points to examine mucociliary differentiation
Adjusted p-valueLog2-fold change
9.4465 × 10-13-4
SPAG6'GATA6 R456C/+; Patient A' vs 'wild type genotype; H9' in 'definitive endoderm cell'cell line, cell type, genotype, individualRNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development
Adjusted p-valueLog2-fold change
1.8711 × 10-44
SPAG6'21 day' vs '0 day'timeTranscription profiling of human airway epithelial cells cultured at an air-liquid interface (ALI) and sampled at multiple time points to examine mucociliary differentiation
Adjusted p-valueLog2-fold change
1.5349 × 10-3-4
SPAG6'ejaculatory azoospermia; Johnsen score count 2' vs 'ejaculatory azoospermia; Johnsen score count 7'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
3.2165 × 10-3-4
SPAG6'MTF2 homozygous knockout' vs 'wild type'phenotypeRNA-seq of human near-haploid cell line HAP1 with CRISPR-edited frameshift mutations
Adjusted p-valueLog2-fold change
1.422 × 10-193.9
SPAG6'normal lung epithelia the third closest to the tumor; normal airway epithelia' vs '; normal'biopsy site, diseaseGene expression profiling of the adjacent airway field cancerization in early stage NSCLC
Adjusted p-valueLog2-fold change
8.1064 × 10-153.9
SPAG6'normal lung epithelia the second farthest from the tumor; normal airway epithelia' vs '; normal'biopsy site, diseaseGene expression profiling of the adjacent airway field cancerization in early stage NSCLC
Adjusted p-valueLog2-fold change
1.3248 × 10-10-3.9
SPAG6'myelodysplastic syndrome; SF3B1 mutated K700E' vs 'normal'disease, genotypeRNA-seq of bone marrow CD34+ cells from myelodysplastic syndrome patients with and without SF3B1 mutation and from healthy controls
Adjusted p-valueLog2-fold change
8.1649 × 10-22-3.8
SPAG6'GATA6 R456C/+; Patient A' vs 'wild type genotype; H9' in 'progenitor cell of endocrine pancreas'cell line, cell type, genotype, individualRNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development
Adjusted p-valueLog2-fold change
6.0871 × 10-183.8
SPAG6'normal lung epithelia the second closest to the tumor; normal airway epithelia' vs '; normal'biopsy site, diseaseGene expression profiling of the adjacent airway field cancerization in early stage NSCLC
Adjusted p-valueLog2-fold change
2.7956 × 10-143.8
SPAG6'normal lung epithelia farthest from the tumor; normal airway epithelia' vs '; normal'biopsy site, diseaseGene expression profiling of the adjacent airway field cancerization in early stage NSCLC
Adjusted p-valueLog2-fold change
8.5231 × 10-83.8
SPAG6'erythroleukemia; ZRSR2 shRNA' vs 'normal'disease, genotypeRNA-seq of bone marrow from patients with myelodysplastic syndrome
Adjusted p-valueLog2-fold change
3.0706 × 10-43.8
SPAG6'14 day' vs '0 day'timeTranscription profiling of human airway epithelial cells cultured at an air-liquid interface (ALI) and sampled at multiple time points to examine mucociliary differentiation
Adjusted p-valueLog2-fold change
4.0993 × 10-173.7
SPAG6'normal lung epithelia closest to the tumor; normal airway epithelia' vs '; normal'biopsy site, diseaseGene expression profiling of the adjacent airway field cancerization in early stage NSCLC
Adjusted p-valueLog2-fold change
1.1642 × 10-6-3.7
SPAG6'teratozoospermia' vs 'normospermic'diseaseTranscription profiling by array of human sperm from normospermic and teratozoospermic individuals
Adjusted p-valueLog2-fold change
1.3849 × 10-3-3.7
SPAG6'ejaculatory azoospermia; Johnsen score count 2' vs 'ejaculatory azoospermia; Johnsen score count 8'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
1.5072 × 10-33.7
SPAG6'10 day' vs '0 day'timeTranscription profiling of human airway epithelial cells cultured at an air-liquid interface (ALI) and sampled at multiple time points to examine mucociliary differentiation
Adjusted p-valueLog2-fold change
4.9263 × 10-23.6
SPAG6'ETV6-RUNX1 shRNA 2' vs 'control shRNA' at '0 hour'RNA interference, timeRNA-seq following shRNA-mediated knock-down of ETV6-RUNX1 in the B-ALL cell line Reh
Adjusted p-valueLog2-fold change
1.8029 × 10-53.5
SPAG6'Human gammaherpesvirus 4' at '14 day' vs 'none' at '0 day'infect, timeInfection of naïve primary human B-lymphocytes with Epstein-Barr virus (EBV) – time course transcriptomic analysis in the pre-latent phase of viral infection
Adjusted p-valueLog2-fold change
2.0882 × 10-3-3.5
SPAG6'squamous cell carcinoma' vs 'normal'block, diseaseRNA-seq of a panel of non-melanoma skin cancer lesions
Adjusted p-valueLog2-fold change
6.2363 × 10-33.4
SPAG6'replicatively senescent; grown until growth arrest' vs 'spontaneously immortal cells; control'phenotype, treatmentPathway Profiling of Replicative and Induced Senescence
Adjusted p-valueLog2-fold change
3.9676 × 10-113.2
SPAG6'SNCA overexpression' vs 'wild type genotype'genotypeRNA-seq of human midbrain organoid models of Parkinson's Disease
Adjusted p-valueLog2-fold change
5.9686 × 10-5-3.2
SPAG6'Influenza A virus (A/California/07-00001/2009(H1N1))' vs 'none' in 'poly(I:C); 25 microgram per milliliter; none'compound, infect, stimulusRNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C.
Adjusted p-valueLog2-fold change
3.7402 × 10-33.2
SPAG6'ssON; 0.5 micromolar' vs 'none' in 'none; none'compound, infect, stimulusRNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C.
Adjusted p-valueLog2-fold change
2.6541 × 10-33.1
SPAG6'8 day' vs '0 day'timeTranscription profiling of human airway epithelial cells cultured at an air-liquid interface (ALI) and sampled at multiple time points to examine mucociliary differentiation
Adjusted p-valueLog2-fold change
2.9853 × 10-343
SPAG6'overexpression of Halo-RelA' vs 'control'phenotypeTranscription profiling by high throughput sequencing of HEK293 cells expressing Halo-RelA, Halo-NFkB1, or Halo tag alone
Adjusted p-valueLog2-fold change
9.0006 × 10-8-3
SPAG6'nasopharyngeal carcinoma' vs 'normal'diseaseTranscription profiling by array of human nasopharyngeal carcinoma patients
Adjusted p-valueLog2-fold change
2.7423 × 10-23
SPAG6'P-bodies (cytosolic RNP granules)' vs 'pre-sorted fraction'fractionRNA-Seq of purified P-bodies from HEK293 cells
Adjusted p-valueLog2-fold change
3.0318 × 10-23
SPAG6'neoplasm' vs 'normal tissue adjacent to neoplasm'sampling siteNext Generation Sequencing Identification of HBV-MLL4 integration and its molecular basis in Chinese hepatocellular carcinoma
Adjusted p-valueLog2-fold change
5.4892 × 10-382.9
SPAG6'HES1 homozygous knockout' vs 'wild type genotype'genotypeRNA-seq of Human Embryonic Stem Cell derived pancreas progenitor differentiation, Day 13 of wildtype, HES1-/-, NEUROG3-/- and HES1-/-NEUROG3-/- genotypes
Adjusted p-valueLog2-fold change
1.2292 × 10-6-2.9
SPAG6'ejaculatory azoospermia; Johnsen score count 5' vs 'normal; Johnsen score count 10'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
7.2746 × 10-6-2.9
SPAG6'K-562; chronic myelogenous (blast crisis) leukemia; P10' vs 'K-562; chronic myelogenous (blast crisis) leukemia; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
1.0607 × 10-32.9
SPAG6'induced pluripotent stem cell' vs 'fibroblast of dermis' in 'normal'cell type, diseaseKlinefelter syndrome derived hiPSCs show similar XCI behavior as female hPSCs
Adjusted p-valueLog2-fold change
3.9612 × 10-32.9
SPAG6'Human gammaherpesvirus 4' at '8 day' vs 'none' at '0 day'infect, timeInfection of naïve primary human B-lymphocytes with Epstein-Barr virus (EBV) – time course transcriptomic analysis in the pre-latent phase of viral infection
Adjusted p-valueLog2-fold change
9.358 × 10-62.8
SPAG6'CD3/CD28 beads' vs 'none' in 'none'stimulus, xenograftRNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs
Adjusted p-valueLog2-fold change
4.6466 × 10-4-2.8
SPAG6'KLF17 overexpression' vs 'wild type' at '5 day'phenotype, timeRNA-seq of hESCs undergoing primed to naive-like resetting via exogenous KLF17 overexpression
Adjusted p-valueLog2-fold change
9.9546 × 10-6-2.7
SPAG6'pancreatic adenocarcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.1103 × 10-42.7
SPAG6'MCT8[P321L]' vs 'wild type genotype' in 'derived neural cell; T3; 100 nanomolar'cell type, compound, genotypeRNA-seq analysis of MCT8-deficient and healthy control brain microvascular endothelial cells (BMECs) and neural cells
Adjusted p-valueLog2-fold change
1.5709 × 10-2-2.7
SPAG6'HER2 Positive Breast Carcinoma; breast carcinoma' vs 'normal'clinical information, diseaseRNA-seq of 17 breast tumor samples of three different subtypes and normal human breast organoids samples
Adjusted p-valueLog2-fold change
2.701 × 10-2-2.7
SPAG6'Neurobasal medium' vs 'DMEM/F12 with glutamax'growth conditionRNA sequencing of human iPSC-derived brain microvascular endothelial cells.
Adjusted p-valueLog2-fold change
1.6759 × 10-4-2.6
SPAG6'hepatobiliary carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
2.3581 × 10-42.6
SPAG6'correction to MCT8[wt]' vs 'wild type genotype' in 'derived neural cell; T3; 100 nanomolar'cell type, compound, genotypeRNA-seq analysis of MCT8-deficient and healthy control brain microvascular endothelial cells (BMECs) and neural cells
Adjusted p-valueLog2-fold change
1.1769 × 10-3-2.6
SPAG6'H1N1 swine influenza virus' vs 'none' at '48 hour'infect, timeSHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.
Adjusted p-valueLog2-fold change
5.0852 × 10-82.5
SPAG6'peripheral zone of prostate' vs 'transition zone of prostate' in 'benign'sampling site, tumor gradingTranscriptional differences between the peripheral and the transcription zone of the prostate
Adjusted p-valueLog2-fold change
5.1386 × 10-42.5
SPAG6'T3; 100 nanomolar' vs 'none' in 'derived neural cell; MCT8[P321L]'cell type, compound, genotypeRNA-seq analysis of MCT8-deficient and healthy control brain microvascular endothelial cells (BMECs) and neural cells
Adjusted p-valueLog2-fold change
4.423 × 10-3-2.5
SPAG6'adenocarcinoma' vs 'normal tissue adjacent to adenocarcinoma'histologyGene expression analysis of lung cancer samples and healthy controls
Adjusted p-valueLog2-fold change
2.8145 × 10-22.5
SPAG6'Influenza A virus (A/California/07-00001/2009(H1N1))' vs 'none' in 'none; none'compound, infect, stimulusRNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C.
Adjusted p-valueLog2-fold change
1.1071 × 10-82.4
SPAG6'valproic acid 4 millimolar' vs 'none'compound, doseTranscription profiling by array of HUVEC cells after treatment with valproic acid
Adjusted p-valueLog2-fold change
2.3768 × 10-22.4
SPAG6'West Nile Virus protein E domain DIII' at '6 hour' vs 'none' at '0 hour'stimulus, timeTranscriptome analysis of human brain microvascular endothelial cells response to interactive DIII domain of protein E of WNV and interactive DIII domain of protein E of TBEV using RNA-seq
Adjusted p-valueLog2-fold change
1.7569 × 10-2-2.3
SPAG6'Mycobacterium tuberculosis' vs 'none' in 'adult'developmental stage, infectMultifaceted dysfunction of infant airway macrophages in response to Mycobacterium tuberculosis
Adjusted p-valueLog2-fold change
6.4824 × 10-6-2.2
SPAG6'non-small cell lung carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.7071 × 10-2-2.2
SPAG6'ejaculatory azoospermia; Johnsen score count 5' vs 'ejaculatory azoospermia; Johnsen score count 7'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
3.778 × 10-2-2.1
SPAG6'Influenza A virus (A/California/07-00001/2009(H1N1))' vs 'none' in 'poly(I:C); 25 microgram per milliliter; ssON; 0.5 micromolar'compound, infect, stimulusRNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C.
Adjusted p-valueLog2-fold change
3.9663 × 10-42
SPAG6' neural stem cell' vs 'induced pluripotent stem cell' in 'Ataxia-telangiectasia'cell type, diseaseHuman iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks
Adjusted p-valueLog2-fold change
2.0974 × 10-32
SPAG6'11 day' vs '0 day'timeRNA-Seq characterization of human H1-derived NPC differentiation timecourse
Adjusted p-valueLog2-fold change
4.2397 × 10-3-2
SPAG6'H1N1 swine influenza virus' vs 'none' at '36 hour'infect, timeSHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.
Adjusted p-valueLog2-fold change
2.0526 × 10-2-2
SPAG6'CA-PDGFRA + sh-p53' vs 'mock'genotypeHuman ESC-based modeling of pediatric gliomas by K27M mutation in histone H3.3 variant
Adjusted p-valueLog2-fold change
9.9234 × 10-8-1.9
SPAG6'smoker; lung adenocarcinoma' vs 'never smoked; normal'clinical information, diseaseGene expression profiling of lung adenocarcinomas and normal lung tissue
Adjusted p-valueLog2-fold change
2.0305 × 10-6-1.9
SPAG6'contrast-enhancing core; glioma' vs 'normal'biopsy site, diseaseTranscription profiling by high throughput sequencing in the margins of glioblastoma
Adjusted p-valueLog2-fold change
2.8306 × 10-41.9
SPAG6'LBH589 (panobinostat)' vs 'DMSO' in 'H295R'cell line, compoundTranscription profiling by array of three human cancer cell lines (H295R, HeLa and MCF-7her2) with and without treatment with histone deacetylase inhibitor LBH589 (panobinostat)
Adjusted p-valueLog2-fold change
5.1869 × 10-3-1.9
SPAG6'familial hemophagocytic lymphohistiocytosis 5' vs 'normal'diseaseRNAseq on PBMC of three patients with Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL5) and three age and sex-matched controls
Adjusted p-valueLog2-fold change
2.0273 × 10-2-1.9
SPAG6'ejaculatory azoospermia; Johnsen score count 2' vs 'ejaculatory azoospermia; Johnsen score count 5'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
3.9984 × 10-21.9
SPAG6'interferon alpha; 1000 international units per millliter' vs 'none' in 'not applicable; CD34-positive, CD38-negative hematopoietic stem cell'cell line, cell type, stimulusTranscriptome analysis of HSPC, THP1 and K562 cells under IFNɑ treatment
Adjusted p-valueLog2-fold change
1.0608 × 10-8-1.8
SPAG6'cells permissive for late gene expression of HPV-16' vs 'control'phenotypeWhole genome analysis of cells permissive for late gene expression of HPV-16
Adjusted p-valueLog2-fold change
1.5365 × 10-81.8
SPAG6'blood alcohol content 0.02%declining' vs 'control' in 'time point 5'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
1.4664 × 10-2-1.8
SPAG6'GATA6 c.618_619insTGCA/+' vs 'wild type genotype' in 'H9; definitive endoderm cell'cell line, cell type, genotype, individualRNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development
Adjusted p-valueLog2-fold change
2.9747 × 10-2-1.8
SPAG6'poly(I:C); 25 microgram per milliliter' vs 'none' in 'Influenza A virus (A/California/07-00001/2009(H1N1)); ssON; 0.5 micromolar'compound, infect, stimulusRNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C.
Adjusted p-valueLog2-fold change
3.0346 × 10-2-1.8
SPAG6'ejaculatory azoospermia; Johnsen score count 3.2' vs 'ejaculatory azoospermia; Johnsen score count 5'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
2.436 × 10-7-1.7
SPAG6'K-562; chronic myelogenous (blast crisis) leukemia; P04' vs 'K-562; chronic myelogenous (blast crisis) leukemia; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
5.6716 × 10-4-1.7
SPAG6'after androgen ablation therapy' vs 'before androgen ablation therapy'treatmentTranscription profiling by high throughput sequencing of advanced prostate cancer treated with androgen-deprivation therapy
Adjusted p-valueLog2-fold change
2.2671 × 10-21.7
SPAG6'5-Aza-deoxycytidine' vs 'none' in 'TC71'cell line, compoundPharmacologic Inhibition of Epigenetic Modification Reveals Targets of Aberrant Promoter Methylation in Ewing Sarcoma
Adjusted p-valueLog2-fold change
9.0787 × 10-81.6
SPAG6'blood alcohol content 0.08%' vs 'control' in 'time point 3'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
2.3514 × 10-6-1.6
SPAG6'cigarette smoke' vs 'control' at '40 day'stimulus, timeRepeated exposure and switching study of cigarette smoke and next generation tobacco product using 3D human bronchial epithelial cells
Adjusted p-valueLog2-fold change
3.7031 × 10-51.6
SPAG6'differentiated; hAKPC-P' vs 'undifferentiated; hAKPC-P'cell type, phenotypeDifferentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes
Adjusted p-valueLog2-fold change
3.2515 × 10-3-1.6
SPAG6'CRISPR-Cas9 induced GNRH1 reporter; 27 day' vs 'wild type genotype; 20 day'genotype, stimulus, timeRNA-Seq of GNRH1 neurons differentiated from human pluripotent stem cells
Adjusted p-valueLog2-fold change
8.0504 × 10-3-1.6
SPAG6'GATA6 c.611_614delACCT/c.611_614delACCT' vs 'wild type genotype' in 'H9; definitive endoderm cell'cell line, cell type, genotype, individualRNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development
Adjusted p-valueLog2-fold change
9.3962 × 10-3-1.6
SPAG6'Severe acute respiratory syndrome-related coronavirus' vs 'none' at '96 hour'infect, timeSHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.
Adjusted p-valueLog2-fold change
5.8548 × 10-71.5
SPAG6'blood alcohol content 0%' vs 'control' in 'time point 1'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
3.5161 × 10-61.5
SPAG6'blood alcohol content 0.04%declining' vs 'control' in 'time point 4'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
2.8251 × 10-5-1.5
SPAG6'autism' vs 'normal'diseaseTranscriptomic analysis of autistic brain reveals convergent molecular pathology [high-throughput sequence data]
Adjusted p-valueLog2-fold change
1.8769 × 10-3-1.5
SPAG6'tumor tissue' vs 'non-malignant tissue'sampling siteRNA-seq of 199 non-small cell lung carcinoma patients and 19 paired normal lung tissues
Adjusted p-valueLog2-fold change
1.9406 × 10-21.5
SPAG6'1 day' vs '0 day'timeRNA-Seq characterization of human H1-derived NPC differentiation timecourse
Adjusted p-valueLog2-fold change
3.5598 × 10-2-1.5
SPAG6'KLF17 overexpression' vs 'wild type phenotype' at '5 day'phenotype, timeRNA-seq of hESCs overexpressing inducible KLF17 versus uninduced controls.
Adjusted p-valueLog2-fold change
9.944 × 10-41.4
SPAG6'group 4 medulloblastoma' vs 'normal'diseaseGene expression profile of pediatric and adult brain tumor types and normal brain
Adjusted p-valueLog2-fold change
2.9667 × 10-3-1.4
SPAG6'H1N1 swine influenza virus' vs 'none' at '12 hour'infect, timeSHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.
Adjusted p-valueLog2-fold change
7.6381 × 10-3-1.4
SPAG6'glioblastoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
3.748 × 10-2-1.4
SPAG6'non-triple-negative breast cancer; breast carcinoma' vs 'normal'clinical information, diseaseRNA-seq of 17 breast tumor samples of three different subtypes and normal human breast organoids samples
Adjusted p-valueLog2-fold change
4.3163 × 10-21.4
SPAG6'group 3 medulloblastoma' vs 'normal'diseaseGene expression profile of pediatric and adult brain tumor types and normal brain
Adjusted p-valueLog2-fold change
4.6329 × 10-71.3
SPAG6'blood alcohol content 0.04%rising' vs 'control' in 'time point 2'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
8.5981 × 10-61.3
SPAG6'epithelial-to-mesenchymal transition' vs 'normal'phenotypeGene expression from H69M versus H69 SCLC cell lines
Adjusted p-valueLog2-fold change
1.4708 × 10-51.3
SPAG6'NKAES-derived NK cells' vs 'primary human NK cells' in 'none'clinical history, compoundTranscription profiling by array of human natural killer cells
Adjusted p-valueLog2-fold change
2.8025 × 10-4-1.3
SPAG6'Astrocytoma, Pilocytic' vs 'normal'diseaseExpression data from human brain tumors and human normal brain
Adjusted p-valueLog2-fold change
3.1578 × 10-4-1.3
SPAG6'H1N1 swine influenza virus' vs 'none' at '24 hour'infect, timeSHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.
Adjusted p-valueLog2-fold change
3.5004 × 10-3-1.3
SPAG6'hyperglycemic condition' vs 'non-diabetic condition'clinical informationTranscription profiling by array of human pancreatic beta cells transplanted into mice
Adjusted p-valueLog2-fold change
2.5875 × 10-21.3
SPAG6'5-Aza-deoxycytidine' vs 'none' in 'A4573'cell line, compoundPharmacologic Inhibition of Epigenetic Modification Reveals Targets of Aberrant Promoter Methylation in Ewing Sarcoma
Adjusted p-valueLog2-fold change
8.2634 × 10-12-1.2
SPAG6'psoriasis; lesional skin' vs 'normal; normal'disease, phenotypeTranscriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms
Adjusted p-valueLog2-fold change
7.9678 × 10-6-1.2
SPAG6'human rhinovirus 16' vs 'vehicle' in 'asthma'disease, infectPhenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus
Adjusted p-valueLog2-fold change
4.8162 × 10-5-1.2
SPAG6'K-562; chronic myelogenous (blast crisis) leukemia; P01' vs 'K-562; chronic myelogenous (blast crisis) leukemia; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
5.232 × 10-4-1.2
SPAG6'pilocytic astrocytoma' vs 'normal'diseaseGene expression profile of pediatric and adult brain tumor types and normal brain
Adjusted p-valueLog2-fold change
2.5028 × 10-3-1.2
SPAG6'synthetic recombinant bat SARS-like coronavirus' vs 'none' at '60 hour'infect, timeSHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.
Adjusted p-valueLog2-fold change
1.1653 × 10-2-1.2
SPAG6'Severe acute respiratory syndrome-related coronavirus dORF6' vs 'none' at '60 hour'infect, timeSHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.
Adjusted p-valueLog2-fold change
3.0977 × 10-21.2
SPAG6'ML792; 400 nanomolar; 48 hour' vs 'dimethyl sulfoxide; 48 hour'compound, timeInfluence of SUMOylation on transcriptional signature of hIPSCs (ChiPS4) assessed by time-resolved RNA-seq in response to ML792 treatment
Adjusted p-valueLog2-fold change
4.9659 × 10-2-1.2
SPAG6'cigarette smoke_stop exposure' vs 'control' at '40 day'stimulus, timeRepeated exposure and switching study of cigarette smoke and next generation tobacco product using 3D human bronchial epithelial cells
Adjusted p-valueLog2-fold change
1.7338 × 10-5-1.1
SPAG6'primary tumor' vs 'adjacent normal tissue'clinical informationTranscription profiling by array of human non-small cell lung cancer tissue from female non-smokers
Adjusted p-valueLog2-fold change
5.073 × 10-3-1.1
SPAG6'glioblastoma' vs 'normal'diseaseExpression data from human brain tumors and human normal brain
Adjusted p-valueLog2-fold change
7.7562 × 10-31.1
SPAG6'16 to 24 weeks post ovulation' vs 'adult' in 'normal'developmental stage, diseaseComparison of gene expression profiling of human lung at four developmental stages and lung adenocarcioma
Adjusted p-valueLog2-fold change
4.4442 × 10-2-1.1
SPAG6'non small cell lung carcinoma neoplasm' vs 'normal tissue adjacent to neoplasm'sampling siteRNA profiling of non-small cell lung cancer
Adjusted p-valueLog2-fold change
4.7105 × 10-2-1.1
SPAG6'tumor tissue' vs 'adjacent non-tumor tissue'sampling siteRNA-seq of prostate cancer and adjacent normal tissues from 14 patients
Adjusted p-valueLog2-fold change
4.5652 × 10-81
SPAG6'ETV5 shRNA' vs 'control shRNA' in 'tumour growth in mouse xenograft'RNA interference, growth conditionRNA-seq of SH-SY5Y NB cells stably transduced with shETV5 compared to parental cells, cell line samples and samples of xenografted tumors
Adjusted p-valueLog2-fold change
7.0456 × 10-5-1
SPAG6'lesion' vs 'normal tissue adjacent to lesion' in '1 week'sampling site, timeRNA-sequencing of the mRNA transcriptome in lesional and non-lesional skin, across three time-points in severe psoriasis patients treated with the tumor necrosis factor (TNF) inhibitor, etanercept
Adjusted p-valueLog2-fold change
3.4282 × 10-41
SPAG6'Ataxia-telangiectasia' vs 'normal'diseaseAtaxia-telangiectasia cerebellar cortex expression
Adjusted p-valueLog2-fold change
7.595 × 10-41
SPAG6'differentiated; hAKPC-P' vs 'undifferentiated; hIPod'cell type, phenotypeDifferentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes
Adjusted p-valueLog2-fold change
3.4342 × 10-3-1
SPAG6'Zaire ebolavirus lacking the VP30 gene' vs 'mock' at '18 hour'infect, timeHuman U937 cell transcriptome response to Zaire Ebola virus wild-type in the delta-”VP30 background and delta-mucin virus
Adjusted p-valueLog2-fold change
3.6728 × 10-31
SPAG6'ZNA; 30 micromolar' vs 'DMSO' at '12 hour'compound, timeRNA-sequencing experiment: Treatment of MCF-7 breast cancer cells with the novel small molecule ZNA
Adjusted p-valueLog2-fold change
6.4916 × 10-3-1
SPAG6'LMP1' vs 'empty vector'genotypeTranscription profiling by array of human LMP1 transfected CD10-positive germinal center B cells
Adjusted p-valueLog2-fold change
7.357 × 10-3-1
SPAG6'smoker; lung adenocarcinoma' vs 'never smoked; lung adenocarcinoma'clinical information, diseaseGene expression profiling of lung adenocarcinomas and normal lung tissue
Adjusted p-valueLog2-fold change
9.0481 × 10-3-1
SPAG6'synthetic recombinant bat SARS-like coronavirus' vs 'none' at '12 hour'infect, timeSHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.
Adjusted p-valueLog2-fold change
1.0486 × 10-2-1
SPAG6'Severe acute respiratory syndrome-related coronavirus dORF6' vs 'none' at '72 hour'infect, timeSHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.
Adjusted p-valueLog2-fold change
2.0652 × 10-2-1
SPAG6'never smoked; lung adenocarcinoma' vs 'never smoked; normal'clinical information, diseaseGene expression profiling of lung adenocarcinomas and normal lung tissue
Adjusted p-valueLog2-fold change
2.3932 × 10-2-1
SPAG6'colon sessile serrated adenoma/polyp' vs 'normal'diseaseRNA-seq of 21 sessile serrated colon adenoma/polyps, 10 hyperplastic polyps, 10 adenomas, 21 uninvolved colon and 20 control colon specimens
Adjusted p-valueLog2-fold change
2.8753 × 10-2-1
SPAG6'adult high grade glioma' vs 'normal'diseaseGene expression profile of pediatric and adult brain tumor types and normal brain
Synonym
CFAP194, CT141, FAP194, PF16, Repro-SA-1
Ortholog
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
Gene biotype
Design element
ILMN_2313378, Hs.158213.0.S1_3p_a_at, 210033_s_at, 7926622, 11719652_s_at, 11740996_a_at, 3238533, 3238555, 3238532, 3238554, 3238557, 3238534, 3238556, 32089_at, 3238537, 210032_PM_s_at, 3238539, 3238538, 210033_PM_s_at, A_24_P21507, 3238550, 3238531, 3238553, 3238530, 3238552, A_23_P75147, A_21_P0006840, 3238529, 9576_at, ILMN_1772458, g3449382_3p_a_at, 210032_s_at, 3238546, 3238545, 3238567, 11756495_a_at, 3238547, 3238569, 11752648_a_at, 11719651_a_at, 3238549, 3238540, 16703150