ENSG00000111245 (MYL2)

homo sapiens

myosin light chain 2

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Homo sapiens
Organism part
Showing 21 experiments:
Created with Highcharts 6.2.0adiposecerebral cortexglobus pallidusmidbrainponssoft tissuevas deferensaortabasal ganglionbreastdiaphragmendometriumforebrainhippocampal formationleft atriumlivermuscle of armolfactory apparatusparotid glandputamenright renal cortexskeletal musclesuprapubic skinthyroidtransverse colon
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GTEX - organism part
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Illumina Body Map
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68 FANTOM5 project - adult
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32 Uhlen's Lab
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Hallstrom et al., 2014 - Organism part
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19 NIH Epigenomics Roadmap
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ENCODE (M. Snyder lab)
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68 FANTOM5 project - fetal
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Mammalian Kaessmann
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HDBR developing brain - 10 post …
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - Carnegie Stage …
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HDBR developing brain - 16 post …
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HDBR developing brain - 15 post …
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Human2021_Tissues - Wang et al. 2019
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Doll et al., 2017 - Organism part
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Human Proteome Map - adult
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Human Proteome Map - fetus
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Linscheid et al., 2020 – Tissues - …
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Human Protein Atlas
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ovary, pancreas, liver, subst. nigra
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Proteomics
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Transcriptomics
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Regulation
-1.1
-9.8
1
11.4
Display log2-fold change
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
7.6066 × 10-411.4
MYL2'tumor tissue' vs 'adjacent non-tumor tissue'sampling siteRNA-seq of prostate cancer and adjacent normal tissues from 14 patients
Adjusted p-valueLog2-fold change
3.6886 × 10-80-9.8
MYL2'induced pluripotent stem cell' vs 'cardiac muscle cell'cell typeGene expression profiling by RNA-seq of human iPSC and iPSC-derived cardiomyocytes from an Yoruban individual (NA19101)
Adjusted p-valueLog2-fold change
9.0621 × 10-5-7.7
MYL2'oral squamous cell carcinoma; neoplasm' vs 'normal; 5 mm beyond neoplasm as visible by narrow band imaging' in 'mouth floor'organism part, sampling siteTranscription profiling by array of oral squamous cell cancer (OSCC) surgical margins defined by narrow band imaging.
Adjusted p-valueLog2-fold change
9.861 × 10-36.9
MYL2'5 mm beyond neoplasm as visible by narrow band imaging' vs '5 mm beyond neoplasm as visible by white light' in 'normal; mouth floor'organism part, sampling siteTranscription profiling by array of oral squamous cell cancer (OSCC) surgical margins defined by narrow band imaging.
Adjusted p-valueLog2-fold change
2.4115 × 10-75.7
MYL2'5-aza-deoxycytidine and trichostatin' vs 'none' in 'HPAF1'cell line, compoundTranscription profiling by array of two human epithelial acinar cell lines, HPAM1 and HPAF1, with global DNA demethylation by 5-aza-deoxycytidine and trichostatin against controls with normal mehtylation levels
Adjusted p-valueLog2-fold change
3.1654 × 10-65.6
MYL2'5-aza-deoxycytidine and trichostatin' vs 'none' in 'HPAM1'cell line, compoundTranscription profiling by array of two human epithelial acinar cell lines, HPAM1 and HPAF1, with global DNA demethylation by 5-aza-deoxycytidine and trichostatin against controls with normal mehtylation levels
Adjusted p-valueLog2-fold change
4.3488 × 10-1054
MYL2'shRNA knockdown of PROX1' vs 'wild type phenotype' in 'U-343_MGa'cell line, phenotypeRNA-seq analysis of PROX1 overexpression and knockdown in glioblastoma cell lines
Adjusted p-valueLog2-fold change
3.9476 × 10-11-4
MYL2'breast carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.7061 × 10-9-3.6
MYL2'colorectal carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
7.4312 × 10-9-3.6
MYL2'pancreatic adenocarcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
3.9628 × 10-23.3
MYL2'MCT8[P321L]' vs 'correction to MCT8[wt]' in 'derived brain microvascular endothelial cell'cell type, compound, genotypeRNA-seq analysis of MCT8-deficient and healthy control brain microvascular endothelial cells (BMECs) and neural cells
Adjusted p-valueLog2-fold change
1.6594 × 10-9-3.2
MYL2'501Mel; shBRG1 knockdown' vs '501Mel; control'cell line, phenotypeBRG1 recruitment by transcription factors MITF and SOX10 defines a specific configuration of regulatory elements in the melanocyte lineage (RNA-seq)
Adjusted p-valueLog2-fold change
2.1936 × 10-23.2
MYL2'Banff score cg greater than 0' vs 'Banff score cg equal 0' in 'kidney transplant negative crossmatch recipient; normal; less than or equal to 1 year'clinical history, clinical information, phenotype, timeIntragraft Gene Expression in Positive Crossmatch Kidney Allografts: Ongoing Inflammation Mediates Chronic Antibody-Mediated Injury
Adjusted p-valueLog2-fold change
4.3335 × 10-33
MYL2'Neurobasal medium' vs 'DMEM/F12 with glutamax'growth conditionRNA sequencing of human iPSC-derived brain microvascular endothelial cells.
Adjusted p-valueLog2-fold change
1.381 × 10-5-2.7
MYL2'450 micromole per liter' vs '50 micromole per liter' in 'doxorubicin' at '2 day'compound, sampling time pointTranscription profiling by array to investigate doxorubicin-induced toxicity in human cardiomyocytes derived from embryonic stem cell line SA121
Adjusted p-valueLog2-fold change
1.0352 × 10-3-2.7
MYL2'hepatobiliary carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.6825 × 10-5-2.6
MYL2'doxorubicin; 450 micromole per liter' vs 'none' at '2 day'compound, sampling time pointTranscription profiling by array to investigate doxorubicin-induced toxicity in human cardiomyocytes derived from embryonic stem cell line SA121
Adjusted p-valueLog2-fold change
1.2428 × 10-5-2.5
MYL2'450 micromole per liter' vs '150 micromole per liter' in 'doxorubicin' at '2 day'compound, sampling time pointTranscription profiling by array to investigate doxorubicin-induced toxicity in human cardiomyocytes derived from embryonic stem cell line SA121
Adjusted p-valueLog2-fold change
2.8125 × 10-2-2.5
MYL2'familial hemophagocytic lymphohistiocytosis 5' vs 'normal'diseaseRNAseq on PBMC of three patients with Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL5) and three age and sex-matched controls
Adjusted p-valueLog2-fold change
6.5893 × 10-32.4
MYL2'trichostatin A; 500 nanomolar' vs 'control'compoundTranscription profiling by high throughput sequencing of human aortic endothelial cell treated with TSA
Adjusted p-valueLog2-fold change
1.4876 × 10-5-2.2
MYL2'non-small cell lung carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
5.7437 × 10-32.2
MYL2'suberoylanilide hydroxamic acid' vs 'control'compoundVascular histone deacetylation by pharmacological HDAC inhibition [SAHA, RNA-seq]
Adjusted p-valueLog2-fold change
7.3852 × 10-82
MYL2'cisplatin; 100 micromolar' vs 'none' in 'TMEM45A knockdown by siRNA'RNA interference, compoundRNA-seq of human head and neck cancer cell line SQD9 knock-out for TMEM45A exposed to cisplatin
Adjusted p-valueLog2-fold change
8.5257 × 10-6-2
MYL2'suberoylanilide hydroxamic acid 10 millimolar' vs 'none'compound, doseTranscription profiling by array of A204 cells after treatment with SAHA
Adjusted p-valueLog2-fold change
4.7251 × 10-4-1.9
MYL2'glioblastoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
6.5832 × 10-41.9
MYL2'kidney transplant; transplant rejection; borderline' vs 'none; normal; none'clinical information, disease, disease stagingExpression of the IL-17/Th17 axis in the development of acute renal allograft rejection
Adjusted p-valueLog2-fold change
4.1623 × 10-2-1.8
MYL2'orlistat; 20 micromolar' vs 'dimethyl sulfoxide'compoundTranscription profiling by array of human HEK293-M2 cells to identify human ORFs conferring resistance to various drug treatments
Adjusted p-valueLog2-fold change
4.4843 × 10-101.7
MYL2'ZNF84 siRNA' vs 'scrambled siRNA' in 'none'RNA interference, compoundRNAseq of HCT116 p53KO cells transfected with siRNA silencing ZNF84 or negative control with either doxorubicin treatment or untreated, cultured 72h post-transfection
Adjusted p-valueLog2-fold change
1.4451 × 10-21.6
MYL2'HCT-116; colon carcinoma; P10' vs 'HCT-116; colon carcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
4.2408 × 10-31.5
MYL2'kidney transplant; transplant rejection; acute' vs 'none; normal; none'clinical information, disease, disease stagingExpression of the IL-17/Th17 axis in the development of acute renal allograft rejection
Adjusted p-valueLog2-fold change
1.9757 × 10-61.4
MYL2'USP22 knockdown by siRNA' vs 'non-targetting siRNA'RNA interferencemRNA-seq of HCT116 USP22 knockdown cells
Adjusted p-valueLog2-fold change
4.7965 × 10-81.2
MYL2'blood alcohol content 0%' vs 'control' in 'time point 1'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
9.3059 × 10-6-1.2
MYL2'AQM' vs 'normal' on 'Affymetrix HG-U133A'diseaseTranscription profiling by array of 12 human muscle diseases
Adjusted p-valueLog2-fold change
1.2827 × 10-41.2
MYL2'RNF40 knockdown by siRNA' vs 'scrambled siRNA' in 'none'RNA interference, stimulusmRNA-seq of HCT116 RNF40 knockdown cells upon TNF-alpha stimulation
Adjusted p-valueLog2-fold change
3.9258 × 10-31.2
MYL2'cisplatin; 100 micromolar' vs 'none' in 'scrambled siRNA'RNA interference, compoundRNA-seq of human head and neck cancer cell line SQD9 knock-out for TMEM45A exposed to cisplatin
Adjusted p-valueLog2-fold change
8.5858 × 10-81.1
MYL2'blood alcohol content 0.02%declining' vs 'control' in 'time point 5'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
1.7285 × 10-61.1
MYL2'blood alcohol content 0.04%declining' vs 'control' in 'time point 4'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
3.0456 × 10-61.1
MYL2'blood alcohol content 0.08%' vs 'control' in 'time point 3'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
4.5126 × 10-51.1
MYL2'RNF40 knockdown by siRNA' vs 'scrambled siRNA' in 'TNFα; 10ng/ml for 30 minutes'RNA interference, stimulusmRNA-seq of HCT116 RNF40 knockdown cells upon TNF-alpha stimulation
Adjusted p-valueLog2-fold change
7.0093 × 10-5-1.1
MYL2'doxorubicin; 100 nanomolar' vs 'none' in 'ZNF84 siRNA'RNA interference, compoundRNAseq of HCT116 p53KO cells transfected with siRNA silencing ZNF84 or negative control with either doxorubicin treatment or untreated, cultured 72h post-transfection
Adjusted p-valueLog2-fold change
9.2944 × 10-31.1
MYL2'PAX2 siRNA' vs 'control'RNA interferenceTranscription profiling by high throughput sequencing of control- and PAX2-siRNA-transfected human epididymis epithelial cells
Adjusted p-valueLog2-fold change
2.2361 × 10-21.1
MYL2'Kaposi's sarcoma-associated herpesvirus' vs 'uninfected control'infectComparison of the transcriptome of K-LEC spheroids to control LEC spheroids
Adjusted p-valueLog2-fold change
2.5695 × 10-21.1
MYL2'transplant rejection' vs 'none' in 'normal'clinical information, diseaseExpression data from human renal allograft biopsies to investigate renal transplant rejection and failure
Adjusted p-valueLog2-fold change
4.6895 × 10-2-1.1
MYL2'Tick-borne encephalitis virus protein E domain DIII' at '6 hour' vs 'none' at '0 hour'stimulus, timeTranscriptome analysis of human brain microvascular endothelial cells response to interactive DIII domain of protein E of WNV and interactive DIII domain of protein E of TBEV using RNA-seq
Adjusted p-valueLog2-fold change
2.7659 × 10-61
MYL2'blood alcohol content 0.04%rising' vs 'control' in 'time point 2'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
7.8266 × 10-41
MYL2'differentiated; hAKPC-P' vs 'undifferentiated; hIPod'cell type, phenotypeDifferentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes
Adjusted p-valueLog2-fold change
1.9221 × 10-31
MYL2'differentiated; hAKPC-P' vs 're-differentiated; hIPod'cell type, phenotypeDifferentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes