7 | | LCT | 'SA181; hepatocyte-like cell' vs 'SA181; embryonic stem cell' | block, cell line, cell type, fraction | Gene expression profile of human embryonic stem cell-derived hepatocyte-like cells |
6.2 | | LCT | 'ChiPS4; hepatocyte-like cell' vs 'ChiPS4; induced pluripotent stem cell' | block, cell line, cell type, fraction | Gene expression profile of human embryonic stem cell-derived hepatocyte-like cells |
-4.6 | | LCT | 'Crohn's disease, undetermined' vs 'non inflammatory bowel disease control' | disease, histology | RNA-seq of 359 treatment-naive pediatric patients with Crohn's disease, patients with ulcerative colitis and control individuals |
-4.6 | | LCT | 'ssON; 0.5 micromolar' vs 'none' in 'poly(I:C); 25 microgram per milliliter; none' | compound, infect, stimulus | RNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C. |
-4.4 | | LCT | 'breast carcinoma' vs 'normal' | block, disease | RNA-seq of blood platelets from six tumor types and healthy donors |
4.3 | | LCT | 'BRD3 homozygous knockout' vs 'wild type' | phenotype | RNA-seq of human near-haploid cell line HAP1 with CRISPR-edited frameshift mutations |
4.3 | | LCT | 'human intestinal organoids derived from H9 stem cells' vs 'Undifferentiated H9 Stem Cells' | cell type | Transcriptional Profiling of human pluripotent stem cells and and derived tissues |
4.1 | | LCT | 'lipopolysaccharide' vs 'none' in 'normal' | disease, stimulus | A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis [RNA-Seq] |
-4 | | LCT | 'Influenza A virus (A/California/07-00001/2009(H1N1))' vs 'none' in 'poly(I:C); 25 microgram per milliliter; none' | compound, infect, stimulus | RNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C. |
-4 | | LCT | 'poly(I:C); 25 microgram per milliliter' vs 'none' in 'none; ssON; 0.5 micromolar' | compound, infect, stimulus | RNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C. |
3.9 | | LCT | 'poly(I:C); 25 microgram per milliliter' vs 'none' in 'none; none' | compound, infect, stimulus | RNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C. |
-3.6 | | LCT | 'colorectal carcinoma' vs 'normal' | block, disease | RNA-seq of blood platelets from six tumor types and healthy donors |
-3.5 | | LCT | 'pancreatic adenocarcinoma' vs 'normal' | block, disease | RNA-seq of blood platelets from six tumor types and healthy donors |
3.5 | | LCT | 'epithelial cell of small intestine' vs 'epithelial cell of large intestine' in 'foetal' | cell type, developmental stage | Transcriptional profiling by array of intestinal epithelial cells from foetal and paediatric gut |
3.4 | | LCT | 'lipopolysaccharide' vs 'none' in 'systemic-onset juvenile idiopathic arthritis' | disease, stimulus | A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis [RNA-Seq] |
3.3 | | LCT | '3 h DRB 0 min 4sU' vs 'untreated' | treatment | 4sUDRB-seq: measuring transcription elongation and initiation genomewide |
3.3 | | LCT | 'ssON; 0.5 micromolar' vs 'none' in 'none; none' | compound, infect, stimulus | RNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C. |
3.3 | | LCT | ' neural stem cell' vs 'induced pluripotent stem cell' in 'Ataxia-telangiectasia' | cell type, disease | Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks |
-3.2 | | LCT | 'non-small cell lung carcinoma' vs 'normal' | block, disease | RNA-seq of blood platelets from six tumor types and healthy donors |
3.2 | | LCT | 'injected in NSG-HLA-A2/HHD mouse' vs 'none' in 'none' | stimulus, xenograft | RNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs |
3.2 | | LCT | 'tumor tissue' vs 'non-malignant tissue' | sampling site | RNA-seq of 199 non-small cell lung carcinoma patients and 19 paired normal lung tissues |
-3 | | LCT | '5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide; 0.4 millimolar' vs 'none' | compound | Transcriptome of primary acute myeloid leukemia (AML) cells treated with AICAr |
3 | | LCT | 'injected in NSG mouse' vs 'none' in 'none' | stimulus, xenograft | RNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs |
-2.9 | | LCT | 'inflammation' vs 'normal tissue adjacent to inflammation' in 'ustekinumab_placebo; Crohn's disease; terminal ileum' at '22 week' | block, cohort, disease, organism part, sampling site, time | A functional genomics predictive network model identifies regulators of inflammatory bowel disease: Microarray Analysis of Human Blood and Intestinal Biopsy Samples from a Phase 2b, Double-blind, Placebo-controlled Study of Ustekinumab in Crohn's Disease |
-2.8 | | LCT | 'hepatobiliary carcinoma' vs 'normal' | block, disease | RNA-seq of blood platelets from six tumor types and healthy donors |
2.7 | | LCT | 'H9; hepatocyte-like cell; hepatocyte-like cell foci' vs 'H9; embryonic stem cell' | block, cell line, cell type, fraction | Gene expression profile of human embryonic stem cell-derived hepatocyte-like cells |
2.7 | | LCT | 'induced pluripotent stem cell' vs 'fibroblast of dermis' in 'normal' | cell type, disease | Klinefelter syndrome derived hiPSCs show similar XCI behavior as female hPSCs |
2.6 | | LCT | 'H9; hepatocyte-like cell; all cells' vs 'H9; embryonic stem cell' | block, cell line, cell type, fraction | Gene expression profile of human embryonic stem cell-derived hepatocyte-like cells |
-2.6 | | LCT | 'hypoxia' vs 'normoxia' at '7 day' | environmental stress, time | Transcription profiling by array of the effect of hypoxia in tumour-initiating cells derived from a colorectal cancer patient |
2.6 | | LCT | 'PI4KB homozygous knockout' vs 'wild type' | phenotype | RNA-seq of human near-haploid cell line HAP1 with CRISPR-edited frameshift mutations |
2.6 | | LCT | 'Influenza A virus (A/California/07-00001/2009(H1N1))' vs 'none' in 'poly(I:C); 25 microgram per milliliter; ssON; 0.5 micromolar' | compound, infect, stimulus | RNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C. |
2.6 | | LCT | 'tumor necrosis factor alpha' vs 'none' in 'brain microvascular endothelial cell; co-culture' | cell type, growth condition, stimulus | Reactive astrocytes transduce blood-brain barrier inflammation through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin |
-2.5 | | LCT | 'Crohn's disease, macroscopic ileal inflammation with deep ulcer' vs 'non inflammatory bowel disease control' | disease, histology | RNA-seq of 359 treatment-naive pediatric patients with Crohn's disease, patients with ulcerative colitis and control individuals |
2.5 | | LCT | 'epithelial cell of small intestine' vs 'epithelial cell of large intestine' in 'paediatric' | cell type, developmental stage | Transcriptional profiling by array of intestinal epithelial cells from foetal and paediatric gut |
2.5 | | LCT | 'esophageal adenocarcinoma' vs 'Barrett’s esophagus; low-grade dysplasia' | disease, disease staging | Whole transcriptome profiling of Esophageal adenocarcinoma and Barrett's |
-2.3 | | LCT | 'Sorafenib; 5 micromolar' vs 'vehicle' in 'HuH-7' | cell line, compound | RNA-seq of human hepatocellular carcinoma cell line Huh7 and immortalized hepatocyte cell line THLE5B treated with experimental compound AD80, Sorafenib, and vehicle for 24 hours |
2.3 | | LCT | 'embryonic stem cell differentiating toward definitive endoderm; 36 hour' vs 'embryonic stem cell; 0 hour' | cell type, time | RNA-seq of definitive endoderm differentiation of human embryonic stem cells in early G1 phase of the cell cycle |
2.3 | | LCT | 'SPI1 -/-' vs 'SPI1 +/+' | genotype | RNA-seq of RS4:11 cell line populations that are unedited (SPI1 +/+), mono (SPI1 +/-) and biallelicaly edited (SPI1 -/-) |
2.3 | | LCT | ' neural stem cell' vs 'induced pluripotent stem cell' in 'normal' | cell type, disease | Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks |
2.2 | | LCT | 'embryonic stem cell differentiating toward definitive endoderm; 60 hour' vs 'embryonic stem cell; 0 hour' | cell type, time | RNA-seq of definitive endoderm differentiation of human embryonic stem cells in early G1 phase of the cell cycle |
2.2 | | LCT | 'BRD4 homozygous knockout' vs 'wild type' | phenotype | RNA-seq of human near-haploid cell line HAP1 with CRISPR-edited frameshift mutations |
2.2 | | LCT | 'Growth Medium' vs 'none' in 'normal' | disease, stimulus | A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis [RNA-Seq] |
2.1 | | LCT | 'non small cell lung carcinoma neoplasm' vs 'normal tissue adjacent to neoplasm' | sampling site | RNA profiling of non-small cell lung cancer |
2.1 | | LCT | 'CD3/CD28 beads' vs 'none' in 'none' | stimulus, xenograft | RNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs |
2.1 | | LCT | 'esophageal adenocarcinoma' vs 'normal' | disease, disease staging | Whole transcriptome profiling of Esophageal adenocarcinoma and Barrett's |
2.1 | | LCT | 'EIF2AK3 homozygous knockout' vs 'wild type' | phenotype | RNA-seq of human near-haploid cell line HAP1 with CRISPR-edited frameshift mutations |
2 | | LCT | 'xenografted under NOD-scid/IL2Rg-null mouse kidney capsule for 10 weeks' vs 'not applicable' in 'organoid culture in matrigel' | growth condition, xenograft | Epithelium-only cultured stem cells isolated from human pluripotent stem cell derived intestinal organoids grown in matrigel and alginate |
-2 | | LCT | 'familial hemophagocytic lymphohistiocytosis 5' vs 'normal' | disease | RNAseq on PBMC of three patients with Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL5) and three age and sex-matched controls |
2 | | LCT | 'ssON; 0.5 micromolar' vs 'none' in 'poly(I:C); 25 microgram per milliliter; Influenza A virus (A/California/07-00001/2009(H1N1))' | compound, infect, stimulus | RNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C. |
2 | | LCT | 'small cell lung carcinoma' vs 'normal' | disease | RNA-seq of primary tumors from 79 small cell lung cancer patients and 7 normal lung tissue |
2 | | LCT | 'UCHL1 homozygous knockout' vs 'wild type' | phenotype | RNA-seq of human near-haploid cell line HAP1 with CRISPR-edited frameshift mutations |
-1.9 | | LCT | 'hypoxia' vs 'normoxia' at '3 day' | environmental stress, time | Transcription profiling by array of the effect of hypoxia in tumour-initiating cells derived from a colorectal cancer patient |
-1.9 | | LCT | 'glioblastoma' vs 'normal' | block, disease | RNA-seq of blood platelets from six tumor types and healthy donors |
1.9 | | LCT | 'esophageal adenocarcinoma' vs 'Barrett’s esophagus; non-dysplastic' | disease, disease staging | Whole transcriptome profiling of Esophageal adenocarcinoma and Barrett's |
-1.8 | | LCT | 'Crohn's disease' vs 'normal' in 'terminal ileum' | disease, organism part | RNA sequencing of purified intestinal epithelial cells from paediatric biopsies including Inflammatory Bowel Disease and healthy controls |
1.8 | | LCT | 'Growth Medium' vs 'none' in 'systemic-onset juvenile idiopathic arthritis' | disease, stimulus | A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis [RNA-Seq] |
-1.8 | | LCT | 'Influenza A virus (A/California/07-00001/2009(H1N1))' vs 'none' in 'none; ssON; 0.5 micromolar' | compound, infect, stimulus | RNA-seq of H1N1 infected monocyte-derived dendritic cells (MoDC), stimulated with single-stranded oligonucleotides (ssON) and/or Poly I:C. |
1.8 | | LCT | 'Crohn's disease; post-operative recurrent (Rutgeerts score ≥i2b)' vs 'normal' | disease, disease staging | Mucosal gene expression profiling in ileum of patients with Crohn's disease |
1.7 | | LCT | 'differentiated; hAKPC-P' vs 're-differentiated; hIPod' | cell type, phenotype | Differentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes |
-1.7 | | LCT | 'actinic keratosis' vs 'normal' | block, disease | RNA-seq of a panel of non-melanoma skin cancer lesions |
1.7 | | LCT | 'definitive endoderm cell; 72 hour' vs 'embryonic stem cell; 0 hour' | cell type, time | RNA-seq of definitive endoderm differentiation of human embryonic stem cells in early G1 phase of the cell cycle |
-1.6 | | LCT | 'Crohn's disease' vs 'non inflammatory bowel disease control' | disease | RNA-seq of 210 treatment-naïve patients of pediatric Crohn's disease and 35 non-IBD controls from the RISK study |
1.6 | | LCT | 'differentiated; hAKPC-P' vs 'undifferentiated; hIPod' | cell type, phenotype | Differentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes |
1.6 | | LCT | 'Crohn's disease' vs 'normal' | disease | RNA-seq of 134 patients undergoing bowel resection for inflammatory bowel disease and controls |
1.6 | | LCT | 'triple-negative breast cancer; breast carcinoma' vs 'normal' | clinical information, disease | RNA-seq of 17 breast tumor samples of three different subtypes and normal human breast organoids samples |
1.5 | | LCT | 'blood alcohol content 0%' vs 'control' in 'time point 1' | sampling time point, treatment | Microarray characterization of gene expression changes in blood during acute ethanol exposure |
1.5 | | LCT | 'blood alcohol content 0.04%rising' vs 'control' in 'time point 2' | sampling time point, treatment | Microarray characterization of gene expression changes in blood during acute ethanol exposure |
1.5 | | LCT | 'blood alcohol content 0.04%declining' vs 'control' in 'time point 4' | sampling time point, treatment | Microarray characterization of gene expression changes in blood during acute ethanol exposure |
-1.5 | | LCT | 'Crohn's disease' vs 'non inflammatory bowel disease control' in 'A1b Paris classification' | clinical information, disease | RNA-seq of ileal biopsies from diagnostic endoscopy of pediatric Crohn's disease patients and non inflammatory bowel disease controls |
-1.5 | | LCT | 'dexamethasone; 1 micromolar' vs 'vehicle' | compound | RNA-seq in GR18 cell line to identify genes regulated by the Glucocorticoid Receptor (24h treatment) |
-1.5 | | LCT | 'sebaceous of Jadassohn nevus' vs 'normal' | block, disease | RNA-seq of a panel of non-melanoma skin cancer lesions |
1.4 | | LCT | 'blood alcohol content 0.02%declining' vs 'control' in 'time point 5' | sampling time point, treatment | Microarray characterization of gene expression changes in blood during acute ethanol exposure |
1.4 | | LCT | 'differentiated; hAKPC-P' vs 'undifferentiated; hAKPC-P' | cell type, phenotype | Differentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes |
1.4 | | LCT | 'human cytomegalovirus (Towne strain)' vs 'none' | infect | RNAseq of proneural glioblastoma stem-like cells 72 hours after infection with human cytomegalovirus (CMV) Towne strain |
1.4 | | LCT | 'RNPS1 knockdown and rescue with RNPS1 loss of function mutant' vs 'wild type phenotype' | phenotype | RNA-Seq of control, RNPS1 knockdown and rescue in HeLa cells |
-1.3 | | LCT | 'Crohn's disease' vs 'non inflammatory bowel disease control' in 'A1a Paris classification' | clinical information, disease | RNA-seq of ileal biopsies from diagnostic endoscopy of pediatric Crohn's disease patients and non inflammatory bowel disease controls |
-1.3 | | LCT | 'Crohn's disease, microscopic ileal inflammation without deep ulcer' vs 'non inflammatory bowel disease control' | disease, histology | RNA-seq of 359 treatment-naive pediatric patients with Crohn's disease, patients with ulcerative colitis and control individuals |
1.3 | | LCT | 'xenografted under NOD-scid/IL2Rg-null mouse kidney capsule for 10 weeks' vs 'not applicable' in 'organoid culture in alginate gel' | growth condition, xenograft | Epithelium-only cultured stem cells isolated from human pluripotent stem cell derived intestinal organoids grown in matrigel and alginate |
-1.3 | | LCT | 'progenitor cell of endocrine pancreas' vs 'definitive endoderm cell' in 'GATA6 R456C/+; Patient A" | cell line, cell type, genotype, individual | RNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development |
1.2 | | LCT | 'AD80; 0.05 micromolar' vs 'vehicle' in 'HuH-7' | cell line, compound | RNA-seq of human hepatocellular carcinoma cell line Huh7 and immortalized hepatocyte cell line THLE5B treated with experimental compound AD80, Sorafenib, and vehicle for 24 hours |
1.2 | | LCT | 'blood alcohol content 0.08%' vs 'control' in 'time point 3' | sampling time point, treatment | Microarray characterization of gene expression changes in blood during acute ethanol exposure |
-1.2 | | LCT | 'psoriasis; lesional skin' vs 'normal; normal' | disease, phenotype | Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms |
-1.2 | | LCT | '7 day' vs '3 day' in 'hypoxia' | environmental stress, time | Transcription profiling by array of the effect of hypoxia in tumour-initiating cells derived from a colorectal cancer patient |
-1.2 | | LCT | 'Crohn's disease, macroscopic ileal inflammation without deep ulcer' vs 'non inflammatory bowel disease control' | disease, histology | RNA-seq of 359 treatment-naive pediatric patients with Crohn's disease, patients with ulcerative colitis and control individuals |
-1.2 | | LCT | 'Crohn's disease; newly diagnosed' vs 'normal' | disease, disease staging | Mucosal gene expression profiling in ileum of patients with Crohn's disease |
1.1 | | LCT | 'ovarian cancer' vs 'normal' in 'epithelial cell' | cell type, disease | A cancer associated fibroblasts (CAFs) specific gene signature in high grade serous ovarian cancer |
-1.1 | | LCT | 'EPZ6438; 10x lowest cytotoxic concentration' vs 'DMSO' in 'SUDHL6' at '6 day' | cell line, compound, time | Expression data from EZH2 inhibitor treated Non-Hodgkins Lymphoma cell lines |
-1.1 | | LCT | 'dexamethasone; 100 nanomolar' vs 'ethanol' at '24 hour' | compound, time | Transcription profiling of human acute lymphoblastic leukemia (ALL) in vitro models to investigate glucocorticoid-regulated microRNAs and mirtrons in ALL |
-1.1 | | LCT | 'tumor' vs 'normal' | clinical information | Whole-Tissue Gene Expression Study of Pancreatic Ductal Adenocarcinoma |
-1.1 | | LCT | 'AML1-ETO fusion gene transduction' vs 'control vector' | genetic modification | Transcription profiling by array of human CD34-positive umbilical cord blood cells after AML1-ETO fusion gene transduction |
-1 | | LCT | 'ETV6-RUNX1 shRNA 2' vs 'control shRNA' at '168 hour' | RNA interference, time | RNA-seq following shRNA-mediated knock-down of ETV6-RUNX1 in the B-ALL cell line Reh |
1 | | LCT | 'hESC derived hepatoblast' vs 'primary hepatocyte' | cell type, compound | Genome-wide analysis of mRNA expression alterations in human primary hepatocytes compared with cAMP treated and non-treated human embryonic stem cell (hESC) derived hepatic populations |
