ENSG00000164049 (FBXW12)

homo sapiens

F-box and WD repeat domain containing 12

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Homo sapiens
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Showing 31 experiments:
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
2.8481 × 10-2-5.6
FBXW12'Snai1 knockout' vs 'wild type'genotypeAmpliseq transcriptomic array of REF seq. genes in Snai1 knock out triple negative breast cancer cells
Adjusted p-valueLog2-fold change
8.248 × 10-21-4.7
FBXW12'breast carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.193 × 10-54.3
FBXW12'induced pluripotent stem cell' vs 'fibroblast of dermis' in 'Klinefelter's syndrome'cell type, diseaseKlinefelter syndrome derived hiPSCs show similar XCI behavior as female hPSCs
Adjusted p-valueLog2-fold change
4.1277 × 10-12-3.8
FBXW12'colorectal carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.1233 × 10-5-3.5
FBXW12'induced MCT8 mutation' vs 'wild type genotype' in 'derived neural cell; T3; 100 nanomolar'cell type, compound, genotypeRNA-seq analysis of MCT8-deficient and healthy control brain microvascular endothelial cells (BMECs) and neural cells
Adjusted p-valueLog2-fold change
7.7378 × 10-10-3.4
FBXW12'pancreatic adenocarcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
4.7811 × 10-12-3.2
FBXW12'non-small cell lung carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.1803 × 10-73.2
FBXW12'induced pluripotent stem cell' vs 'fibroblast of dermis' in 'normal'cell type, diseaseKlinefelter syndrome derived hiPSCs show similar XCI behavior as female hPSCs
Adjusted p-valueLog2-fold change
3.0666 × 10-4-3.2
FBXW12'T3; 100 nanomolar' vs 'none' in 'derived neural cell; induced MCT8 mutation'cell type, compound, genotypeRNA-seq analysis of MCT8-deficient and healthy control brain microvascular endothelial cells (BMECs) and neural cells
Adjusted p-valueLog2-fold change
1.6279 × 10-42.8
FBXW12'12 hour' vs '0 hour' in 'MCF-10A'cell line, timeKnock-in of PIK3CA-H1047R into MCF-10A
Adjusted p-valueLog2-fold change
1.2767 × 10-2-2.7
FBXW12'COVID-19' vs 'normal' in 'lung'disease, organism partLung and colon transcriptome profiling of fatal COVID-19 cases
Adjusted p-valueLog2-fold change
1.7413 × 10-22.7
FBXW12'Human gammaherpesvirus 4' at '8 day' vs 'none' at '0 day'infect, timeInfection of naïve primary human B-lymphocytes with Epstein-Barr virus (EBV) – time course transcriptomic analysis in the pre-latent phase of viral infection
Adjusted p-valueLog2-fold change
1.0571 × 10-4-2.4
FBXW12' neural stem cell' vs 'induced pluripotent stem cell' in 'normal'cell type, diseaseHuman iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks
Adjusted p-valueLog2-fold change
2.3436 × 10-4-2.4
FBXW12'hepatobiliary carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
3.8812 × 10-42.4
FBXW12'induced pluripotent stem cell' vs 'cardiac muscle cell'cell typeGene expression profiling by RNA-seq of human iPSC and iPSC-derived cardiomyocytes from an Yoruban individual (NA19101)
Adjusted p-valueLog2-fold change
2.6087 × 10-3-2.4
FBXW12'neoplasm' vs 'normal tissue adjacent to neoplasm'sampling siteGlobal gene expression profiles of 10 gastric cancer (GC) samples and 10 gastric normal adjacent tissue (gNAT) samples
Adjusted p-valueLog2-fold change
1.2843 × 10-5-2.1
FBXW12'glioblastoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.3459 × 10-2-2.1
FBXW12'familial hemophagocytic lymphohistiocytosis 5' vs 'normal'diseaseRNAseq on PBMC of three patients with Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL5) and three age and sex-matched controls
Adjusted p-valueLog2-fold change
2.9168 × 10-2-2.1
FBXW12'3 h DRB 8 min 4sU' vs 'untreated'treatment4sUDRB-seq: measuring transcription elongation and initiation genomewide
Adjusted p-valueLog2-fold change
3.4211 × 10-2-2.1
FBXW12'valproic acid; 15 millimolar' vs 'control' at '2 day'compound, sampling time pointRNA-seq of Primary Human Hepatocytes (PHH) exposed to Valproic Acid (VPA) for 3 days daily and 3 days daily exposure followed by 3 days washout.
Adjusted p-valueLog2-fold change
1.0001 × 10-71.9
FBXW12'progenitor cell of endocrine pancreas' vs 'definitive endoderm cell' in 'GATA6 R456C/+; Patient A"cell line, cell type, genotype, individualRNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development
Adjusted p-valueLog2-fold change
4.0648 × 10-51.8
FBXW12'TIGAR knockdown' vs 'wild type'phenotypeRNA-seq of human cancer cell line OVCA420* following TIGAR knockdown with shRNA
Adjusted p-valueLog2-fold change
5.6154 × 10-31.8
FBXW12'PLX4720; 1 micromolar' vs 'none'compoundRNA-seq of the human melanoma cell-line A375P treated with the BRAF inhibitor PLX4720 and a DMSO control
Adjusted p-valueLog2-fold change
2.8587 × 10-31.7
FBXW12'colorectal cancer metastatic in the liver' vs 'normal'biopsy siteRNA-seq of 54 samples (normal colon, primary tumor, and liver metastases) from 18 colorectal cancer patients
Adjusted p-valueLog2-fold change
4.3489 × 10-21.7
FBXW12'doxycycline-mediated expression of dominant-negative FOS' vs 'wild type'phenotypeTranscription profiling of oesophageal adenocarcinoma by RNA-seq
Adjusted p-valueLog2-fold change
4.5058 × 10-4-1.6
FBXW12'human intestinal organoids derived from H9 stem cells' vs 'Undifferentiated H9 Stem Cells'cell typeTranscriptional Profiling of human pluripotent stem cells and and derived tissues
Adjusted p-valueLog2-fold change
1.3178 × 10-31.6
FBXW12'Human betacoronavirus 2c England-Qatar/2012; 24 hour' vs 'mock; 18 hour'infect, timeTranscription profiling of human bronchial epithelial cell line Calu-3 2B4 infected with Human Coronavirus MERS-CoV-London
Adjusted p-valueLog2-fold change
1.4963 × 10-111.5
FBXW12'overexpression of Halo-RelA' vs 'control'phenotypeTranscription profiling by high throughput sequencing of HEK293 cells expressing Halo-RelA, Halo-NFkB1, or Halo tag alone
Adjusted p-valueLog2-fold change
3.1777 × 10-41.5
FBXW12'human cytomegalovirus (Towne strain)' vs 'none'infectRNAseq of proneural glioblastoma stem-like cells 72 hours after infection with human cytomegalovirus (CMV) Towne strain
Adjusted p-valueLog2-fold change
1.8967 × 10-3-1.5
FBXW12'definitive endoderm cell; 72 hour' vs 'embryonic stem cell; 0 hour'cell type, timeRNA-seq of definitive endoderm differentiation of human embryonic stem cells in early G1 phase of the cell cycle
Adjusted p-valueLog2-fold change
5.57 × 10-3-1.5
FBXW12' neural stem cell' vs 'induced pluripotent stem cell' in 'Ataxia-telangiectasia'cell type, diseaseHuman iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks
Adjusted p-valueLog2-fold change
8.257 × 10-3-1.5
FBXW12'squamous cell carcinoma' vs 'normal'block, diseaseRNA-seq of a panel of non-melanoma skin cancer lesions
Adjusted p-valueLog2-fold change
9.711 × 10-41.4
FBXW12'differentiated; hAKPC-P' vs 're-differentiated; hIPod'cell type, phenotypeDifferentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes
Adjusted p-valueLog2-fold change
6.8479 × 10-3-1.4
FBXW12'ulcerative colitis' vs 'normal'diseasePSC-IBD mucosal biology
Adjusted p-valueLog2-fold change
2.5567 × 10-31.3
FBXW12'Zaire ebolavirus lacking the mucin domain of GP' vs 'mock' at '18 hour'infect, timeHuman U937 cell transcriptome response to Zaire Ebola virus wild-type in the delta-”VP30 background and delta-mucin virus
Adjusted p-valueLog2-fold change
1.7331 × 10-21.3
FBXW12'501Mel; shBRG1 knockdown' vs '501Mel; control'cell line, phenotypeBRG1 recruitment by transcription factors MITF and SOX10 defines a specific configuration of regulatory elements in the melanocyte lineage (RNA-seq)
Adjusted p-valueLog2-fold change
2.1438 × 10-2-1.3
FBXW12'definitive endoderm differentiated from H9 stem cells' vs 'Undifferentiated H9 Stem Cells'cell typeTranscriptional Profiling of human pluripotent stem cells and and derived tissues
Adjusted p-valueLog2-fold change
1.0436 × 10-31.2
FBXW12'differentiated; hAKPC-P' vs 'undifferentiated; hIPod'cell type, phenotypeDifferentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes
Adjusted p-valueLog2-fold change
1.782 × 10-31.2
FBXW12'differentiated; hAKPC-P' vs 'undifferentiated; hAKPC-P'cell type, phenotypeDifferentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes
Adjusted p-valueLog2-fold change
1.6033 × 10-2-1.2
FBXW12'embryonic stem cell differentiating toward definitive endoderm; 60 hour' vs 'embryonic stem cell; 0 hour'cell type, timeRNA-seq of definitive endoderm differentiation of human embryonic stem cells in early G1 phase of the cell cycle
Adjusted p-valueLog2-fold change
2.1866 × 10-2-1.2
FBXW12'resembling native pluripotent cell; 3iL inducer' vs 'wild type; none'phenotype, treatmentRNA-Seq of 3iL human embryonic stem cells with an induced expression profile that more closely resembles native pluripotent cells and uninduced controls
Adjusted p-valueLog2-fold change
3.748 × 10-21.2
FBXW12'KLF17 overexpression' vs 'wild type phenotype' at '2 day'phenotype, timeRNA-seq of hESCs overexpressing inducible KLF17 versus uninduced controls.
Adjusted p-valueLog2-fold change
8.9838 × 10-31.1
FBXW12'CRISPR-Cas9 induced GNRH1 reporter; 27 day' vs 'wild type genotype; 20 day'genotype, stimulus, timeRNA-Seq of GNRH1 neurons differentiated from human pluripotent stem cells
Adjusted p-valueLog2-fold change
1.9904 × 10-2-1.1
FBXW12'sebaceous of Jadassohn nevus' vs 'normal'block, diseaseRNA-seq of a panel of non-melanoma skin cancer lesions
Adjusted p-valueLog2-fold change
4.9659 × 10-21.1
FBXW12'tumor tissue' vs 'non-malignant tissue'sampling siteRNA-seq of 199 non-small cell lung carcinoma patients and 19 paired normal lung tissues
Adjusted p-valueLog2-fold change
6.1236 × 10-71
FBXW12'blood alcohol content 0.08%' vs 'control' in 'time point 3'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
6.2114 × 10-61
FBXW12'blood alcohol content 0.04%declining' vs 'control' in 'time point 4'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
3.0432 × 10-51
FBXW12'blood alcohol content 0.04%rising' vs 'control' in 'time point 2'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
2.1154 × 10-41
FBXW12'cultured skin substitute; 28 day' vs 'skin; 0 day'organism part, timeTranscription profiling by array of human grafted engineered skin substitutes
Adjusted p-valueLog2-fold change
7.5851 × 10-31
FBXW12'NSAID-exacerbated respiratory disease' vs 'normal'diseaseTotal RNAseq of human healthy control inferior turbinate and glucocorticoid-treated, NSAID-exacerbated respiratory disease (N-ERD) nasal polyp nasal brushings
Adjusted p-valueLog2-fold change
1.6173 × 10-21
FBXW12'Zaire ebolavirus lacking the VP30 gene' vs 'mock' at '18 hour'infect, timeHuman U937 cell transcriptome response to Zaire Ebola virus wild-type in the delta-”VP30 background and delta-mucin virus
Adjusted p-valueLog2-fold change
4.1141 × 10-2-1
FBXW12'embryonic stem cell differentiating toward definitive endoderm; 36 hour' vs 'embryonic stem cell; 0 hour'cell type, timeRNA-seq of definitive endoderm differentiation of human embryonic stem cells in early G1 phase of the cell cycle