ENSG00000178802 (MPI)

homo sapiens

mannose phosphate isomerase

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Homo sapiens
Organism part
Showing 71 experiments:
Created with Highcharts 6.2.0adiposecortex of kidneyhippocampusoccipital lobeseminal vesicleumbilical cordaortabasal ganglionbreastcerebral cortexduodenumesophagogastric junctionforebrain fragmentheartleft cardiac atriumlocus ceruleusmidbrainmuscle of armparietal lobeplateletpulmonary valveright atriumsmooth musclesubcutaneous adipose tissuetemporal lobetibial arteryvermiform appendix
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68 FANTOM5 project - adult
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GTEX - organism part
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32 Uhlen's Lab
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Hallstrom et al., 2014 - Organism part
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68 FANTOM5 project - fetal
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19 NIH Epigenomics Roadmap
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Illumina Body Map
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HDBR developing brain - 9 post …
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ENCODE (M. Snyder lab)
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Mammalian Kaessmann
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Zhu et al., 2018 - Organism part
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Human Protein Atlas
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Human2021_Tissues - Wang et al. 2019
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Human Proteome Map - adult
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Doll et al., 2017 - Organism part
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McKetney et al., 2019 – organism part …
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brain regions
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Human Proteome Map - fetus
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ovary, pancreas, liver, subst. nigra
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Linscheid et al., 2020 – Tissues - …
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corpus callosum and temporal lobe
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cerebellum and occipital lobe
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Experiment type
Experimental variables
Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
2.2257 × 10-8-2.9
MPI'154; 1 micromolar' vs 'DMSO'compoundDevelopment of a small molecule for treatment of castration resistant prostate cancer via androgen receptor and IL6/STAT3 pathways
Adjusted p-valueLog2-fold change
2.9306 × 10-77-2.6
MPI'Digoxin; 400 nanomolar' vs 'DMSO'compoundExpression profiling of Jurkat cells infected with HIV-1 and treated with digoxin or DMSO
Adjusted p-valueLog2-fold change
1.8119 × 10-31-2.6
MPI'P-bodies (cytosolic RNP granules)' vs 'pre-sorted fraction'fractionRNA-Seq of purified P-bodies from HEK293 cells
Adjusted p-valueLog2-fold change
2.0205 × 10-15-2.5
MPI'non-small cell lung carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
6.8845 × 10-9-2.3
MPI"after autologous stem cell transplantation" vs "before autologous stem cell transplantation"timeRNA-seq of human multiple myeloma patients myeloid-derived suppressor cells (M-MDSC)
Adjusted p-valueLog2-fold change
1.0506 × 10-64-2.2
MPI'CCNK knock-down' vs 'mock'RNA interferenceRNA-seq analysis of vorinostat-resistant HCT116 cells following gene knockdown of potential vorinostat-resistance candidate genes
Adjusted p-valueLog2-fold change
1.2735 × 10-11-2.2
MPI'colorectal carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
8.9318 × 10-11-2.1
MPI'breast carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.1169 × 10-8-2.1
MPI'pancreatic adenocarcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.2413 × 10-52.1
MPI'erythroleukemia; ZRSR2 shRNA' vs 'normal'disease, genotypeRNA-seq of bone marrow from patients with myelodysplastic syndrome
Adjusted p-valueLog2-fold change
9.593 × 10-62
MPI'Snail overexpression' vs 'control'treatmentExpression data from breast cancer cell line MCF-7 with ectopic expression of the transcription factor Snail
Adjusted p-valueLog2-fold change
6.1483 × 10-91.9
MPI'control media in hypoxia (1% pO2)' vs 'control'growth conditionThe genomic analysis of the interaction between the lactic acidosis and hypoxia response
Adjusted p-valueLog2-fold change
9.1245 × 10-8-1.9
MPI'deferoxamine; HIF-1a siRNA' vs 'deferoxamine; none'growth condition, treatmentTranscription profiling by array of human glioblastoma cells after stimulation with deferoxamine and treatment with polyamide 1, echinomycin, or HIF-1a siRNA
Adjusted p-valueLog2-fold change
4.6308 × 10-7-1.9
MPI'154; 0.4 micromolar' vs 'DMSO'compoundDevelopment of a small molecule for treatment of castration resistant prostate cancer via androgen receptor and IL6/STAT3 pathways
Adjusted p-valueLog2-fold change
2.4898 × 10-7-1.8
MPI'deferoxamine; 100 nanomolar echinomycin' vs 'deferoxamine; none'growth condition, treatmentTranscription profiling by array of human glioblastoma cells after stimulation with deferoxamine and treatment with polyamide 1, echinomycin, or HIF-1a siRNA
Adjusted p-valueLog2-fold change
3.2455 × 10-71.8
MPI'hypoxia' vs 'normoxia' in 'SNF96.2'cell line, growth conditionHypoxia and Intrinsic Transcriptomic Subtyping of Soft Tissue Sarcoma
Adjusted p-valueLog2-fold change
1.2771 × 10-6-1.7
MPI'GLV-1h153' at '24 hour' vs 'control'infect, timeExpression data from human pancreatic cells PANC-1 infected with oncolytic vaccinia virus GLV-1h153
Adjusted p-valueLog2-fold change
2.1335 × 10-6-1.7
MPI'glioblastoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.8685 × 10-41.7
MPI'psoriasis' vs 'normal' in 'Ovation RNA Amplification V2 kit'disease, protocolDominant Th1 and Minimal Th17 Skewing in Discoid Lupus Revealed by Transcriptomic Comparison with Psoriasis
Adjusted p-valueLog2-fold change
2.132 × 10-331.6
MPI'cisplatin; 100 micromolar' vs 'none' in 'scrambled siRNA'RNA interference, compoundRNA-seq of human head and neck cancer cell line SQD9 knock-out for TMEM45A exposed to cisplatin
Adjusted p-valueLog2-fold change
1.0685 × 10-31.5
MPI'hypoxia' vs 'normoxia' in '93T449'cell line, growth conditionHypoxia and Intrinsic Transcriptomic Subtyping of Soft Tissue Sarcoma
Adjusted p-valueLog2-fold change
1.4616 × 10-2-1.5
MPI'metastasis; tumor' vs 'metastasis; normal adjacent tissue'clinical information, sampling siteGene expression profile of primary colorectal tumors with and without distant metastasis
Adjusted p-valueLog2-fold change
2.5022 × 10-2-1.5
MPI'neuregulin' vs 'none' at '24 hour'compound, timeExpression data from MCF7 cells treated with Neuregulin (NRG) at different times
Adjusted p-valueLog2-fold change
3.6089 × 10-14-1.4
MPI'EX00000246; stimulated with interferon gamma and lipopolysaccharide' vs 'none' at '24 hour'compound, time, treatmentGPBAR1 agonism has a broad impact on blocking macrophage activation
Adjusted p-valueLog2-fold change
3.0317 × 10-101.4
MPI'3 to 5 weeks post ovulation' vs 'adult' in 'normal'developmental stage, diseaseComparison of gene expression profiling of human lung at four developmental stages and lung adenocarcioma
Adjusted p-valueLog2-fold change
3.331 × 10-10-1.4
MPI'heat-killed Escherichia coli' vs 'none' in 'ulcerative colitis'disease, stimulusTranscription profiling by array of primary human macrophages cultured from patients with ulcerative colitis or healthy individuals with or without stimulation by heat-killed E. coli
Adjusted p-valueLog2-fold change
2.5388 × 10-6-1.4
MPI'3 h DRB 0 min 4sU' vs 'untreated'treatment4sUDRB-seq: measuring transcription elongation and initiation genomewide
Adjusted p-valueLog2-fold change
5.5019 × 10-5-1.4
MPI'ochratoxin A; 130 nanomolar' vs 'none' at '3 day'compound, timeMicroarray mRNA data of RPTEC/TERT1 cells exposed to nephrotoxic chemicals ochratoxin A and potassium bromate
Adjusted p-valueLog2-fold change
1.3247 × 10-41.4
MPI'astrocyte overexpressing 4 genes' vs 'glioblastoma cell line'phenotypeTranscription profiling by array of human primary astrocytes, cancer stem cells derived from astrocytes overexpressing various oncogenic and iPSC-inducing factors, glioma stem cells and gliblastomat cell line to compare their expression profiles and tumor-initiating capabilities
Adjusted p-valueLog2-fold change
1.9276 × 10-4-1.4
MPI'shco4 shRNA targeting Coco' vs 'control'RNA interferenceGene expression data from MDA-MB231 cells stably transduced with lentiviral vectors encoding a control shRNA (shscramble) or two shRNAs targeting Coco (shco2 and shco4)
Adjusted p-valueLog2-fold change
2.4921 × 10-31.4
MPI'activated B cell' vs 'memory B cell'cell typeTranscription profiling by array of human activated B cells, plasmablasts and plasma cells compared to memory B cells
Adjusted p-valueLog2-fold change
3.5741 × 10-171.3
MPI'cisplatin; 100 micromolar' vs 'none' in 'TMEM45A knockdown by siRNA'RNA interference, compoundRNA-seq of human head and neck cancer cell line SQD9 knock-out for TMEM45A exposed to cisplatin
Adjusted p-valueLog2-fold change
3.7174 × 10-10-1.3
MPI'DMSO' in 'stimulated with interferon gamma and lipopolysaccharide' vs 'none' at '24 hour'compound, time, treatmentGPBAR1 agonism has a broad impact on blocking macrophage activation
Adjusted p-valueLog2-fold change
9.4515 × 10-9-1.3
MPI'RNPS1 knockdown' vs 'wild type phenotype'phenotypeRNA-Seq of control, RNPS1 knockdown and rescue in HeLa cells
Adjusted p-valueLog2-fold change
3.8859 × 10-8-1.3
MPI'RNPS1 knockdown and rescue with RNPS1 loss of function mutant' vs 'wild type phenotype'phenotypeRNA-Seq of control, RNPS1 knockdown and rescue in HeLa cells
Adjusted p-valueLog2-fold change
4.9732 × 10-8-1.3
MPI'systemic-onset juvenile idiopathic arthritis; placebo, Prednisone, non-steroidal anti-inflammatory drug, methotrexate' vs 'normal; none'disease, treatmentGene expression data of whole blood of systemic juvenile idiopathic arthritis (SJIA) patients treated with canakinumab or placebo and age matched healthy controls
Adjusted p-valueLog2-fold change
1.3313 × 10-61.3
MPI'NCI-H460; large cell lung carcinoma; P04' vs 'NCI-H460; large cell lung carcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
4.0486 × 10-5-1.3
MPI'SARS coronavirus Urbani ΔORF6 mutant' vs 'mock' at '54 hour'infect, timeTime course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells
Adjusted p-valueLog2-fold change
4.1624 × 10-51.3
MPI'early mesodermal progenitors' vs 'undifferentiated cells'populationExpression data from undifferentiated human embryonic stem cells (hESC) and Day 3.5 mesodermal progenitor (CD326neg CD56+) population
Adjusted p-valueLog2-fold change
4.2663 × 10-5-1.3
MPI'ochratoxin A; 130 nanomolar' vs 'none' at '5 day'compound, timeMicroarray mRNA data of RPTEC/TERT1 cells exposed to nephrotoxic chemicals ochratoxin A and potassium bromate
Adjusted p-valueLog2-fold change
5.4645 × 10-4-1.3
MPI'heat-killed Escherichia coli' vs 'none' in 'normal'disease, stimulusTranscription profiling by array of primary human macrophages cultured from patients with ulcerative colitis or healthy individuals with or without stimulation by heat-killed E. coli
Adjusted p-valueLog2-fold change
9.2554 × 10-41.3
MPI'astrocyte overexpressing 4 genes' vs 'astrocyte'phenotypeTranscription profiling by array of human primary astrocytes, cancer stem cells derived from astrocytes overexpressing various oncogenic and iPSC-inducing factors, glioma stem cells and gliblastomat cell line to compare their expression profiles and tumor-initiating capabilities
Adjusted p-valueLog2-fold change
2.11 × 10-3-1.3
MPI'metastatic recurrence; tumor' vs 'metastatic recurrence; normal adjacent tissue'clinical information, sampling siteGene expression profile of primary colorectal tumors with and without distant metastasis
Adjusted p-valueLog2-fold change
7.0465 × 10-3-1.3
MPI'Neisserial ligand MafA' vs 'none'infect, stimulusTranscriptome analysis of human brain microvascular endothelial cells response to Neisseria meningitidis and its antigen MafA using RNA-seq
Adjusted p-valueLog2-fold change
2.9945 × 10-14-1.2
MPI'5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide; 0.4 millimolar' vs 'none'compoundTranscriptome of primary acute myeloid leukemia (AML) cells treated with AICAr
Adjusted p-valueLog2-fold change
7.3948 × 10-8-1.2
MPI'THZ1 (35 nanomolar)' vs 'none'compoundRNA-seq of IMR-5/75 neuroblastoma cell line treated with JQ1, THZ1 or combination against untreated controls
Adjusted p-valueLog2-fold change
4.8859 × 10-61.2
MPI'MDAMB231; cocultured with fibroblast HFF1' vs 'MDAMB231; normal'cell line, growth conditionSystem-Wide Analysis Reveals a Complex Network of Tumor-Fibroblast Interactions Involved in Tumorigenicity
Adjusted p-valueLog2-fold change
9.4967 × 10-6-1.2
MPI'DMSO-mediated cell differentiation prior to experiment' vs 'not cultured with DMSO' in 'none'compound, growth conditionRNA-microarray analysis of PLB-985 cells cultured with or without interferon-gamma under both conditions that induce or do not induce cell differentiation
Adjusted p-valueLog2-fold change
1.344 × 10-5-1.2
MPI'SARS coronavirus Urbani ΔORF6 mutant' vs 'mock' at '48 hour'infect, timeTime course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells
Adjusted p-valueLog2-fold change
1.6441 × 10-5-1.2
MPI'ochratoxin A; 130 nanomolar' vs 'none' at '1 day'compound, timeMicroarray mRNA data of RPTEC/TERT1 cells exposed to nephrotoxic chemicals ochratoxin A and potassium bromate
Adjusted p-valueLog2-fold change
1.7663 × 10-41.2
MPI'3 day' vs '0 day'timeGlobal expression profiling time series of early human embryonic stem cell differentiation towards the mesoderm lineage
Adjusted p-valueLog2-fold change
2.394 × 10-41.2
MPI'10 unit per milliliter; JFHA' vs 'control'compoundPrimary human hepatocytes treated with IL28B and the HCV JFH1 Genotype 2A clone.
Adjusted p-valueLog2-fold change
2.5759 × 10-4-1.2
MPI'PARK2 overexpression' vs 'control'genotypeExpression data from PARK2 overexpression in U251 cells
Adjusted p-valueLog2-fold change
5.4882 × 10-4-1.2
MPI'BRD4 inhibitor JQ1' vs 'none' in '92'cell line, compoundTranscription profiling by array of uveal melanoma cell lines with wild type and mutant G-proteins (GNAQ or GNA11) in response to treatment with BRAD4 inhibitor JQ1
Adjusted p-valueLog2-fold change
6.8724 × 10-41.2
MPI'DAOY M14; MYC overexpression' vs 'DAOY; wild type'cell type, genotypeBone morphogenetic protein-7 is a MYC target with pro-survival functions in childhood medulloblastoma
Adjusted p-valueLog2-fold change
1.1819 × 10-21.2
MPI'neoplasm' vs 'normal tissue adjacent to neoplasm' in 'clear cell renal cell carcinoma'disease, sampling siteHLA ligand profiles of primary renal cell carcinoma maintained in metastases.sue
Adjusted p-valueLog2-fold change
2.7461 × 10-21.2
MPI'hypoxia' vs 'normoxia' in 'SW684'cell line, growth conditionHypoxia and Intrinsic Transcriptomic Subtyping of Soft Tissue Sarcoma
Adjusted p-valueLog2-fold change
1.8273 × 10-16-1.1
MPI'PRPF8' vs 'control'RNA interferenceRegulation of constitutive and alternative messenger RNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength
Adjusted p-valueLog2-fold change
2.1372 × 10-161.1
MPI'KLF17 overexpression' at '5 day' vs 'wild type' at '0 day'phenotype, timeRNA-seq of hESCs undergoing primed to naive-like resetting via exogenous KLF17 overexpression
Adjusted p-valueLog2-fold change
2.8121 × 10-16-1.1
ENSG00000178802'colon adenocarcinoma' vs 'normal'diseaseRNA-seq of 21 sessile serrated colon adenoma/polyps, 10 hyperplastic polyps, 10 adenomas, 21 uninvolved colon and 20 control colon specimens
Adjusted p-valueLog2-fold change
2.2831 × 10-10-1.1
MPI'sulforaphane; normal' at '6 hour' vs 'DMSO; normal' at '6 hour'compound, disease, timeGenome-wide transcriptome analysis of the dietary chemopreventive phytochemical sulforaphane on normal and prostate cancer cells.
Adjusted p-valueLog2-fold change
1.3282 × 10-8-1.1
ENSG00000178802'lipopolysaccharide' vs 'none' in 'systemic-onset juvenile idiopathic arthritis'disease, stimulusA multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis [RNA-Seq]
Adjusted p-valueLog2-fold change
4.0852 × 10-7-1.1
MPI'ejaculatory azoospermia; Johnsen score count 5' vs 'normal; Johnsen score count 10'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
9.9268 × 10-7-1.1
MPI'esophageal adenocarcinoma' vs 'Barrett’s esophagus; low-grade dysplasia'disease, disease stagingWhole transcriptome profiling of Esophageal adenocarcinoma and Barrett's
Adjusted p-valueLog2-fold change
1.0859 × 10-6-1.1
MPI'HOP-62; adenocarcinoma of lung; P10' vs 'HOP-62; adenocarcinoma of lung; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
6.2541 × 10-6-1.1
MPI'JQ1 (1 micromolar) and THZ1 (35 nanomolar)' vs 'none'compoundRNA-seq of IMR-5/75 neuroblastoma cell line treated with JQ1, THZ1 or combination against untreated controls
Adjusted p-valueLog2-fold change
1.2691 × 10-5-1.1
MPI'SARS coronavirus Urbani ΔORF6 mutant' vs 'mock' at '60 hour'infect, timeTime course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells
Adjusted p-valueLog2-fold change
1.2729 × 10-5-1.1
MPI'SARS coronavirus Urbani' vs 'mock' at '36 hour'infect, timeTime course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells
Adjusted p-valueLog2-fold change
5.9244 × 10-51.1
MPI'10 day' vs '0 day'timeGlobal expression profiling time series of early human embryonic stem cell differentiation towards the mesoderm lineage
Adjusted p-valueLog2-fold change
1.3304 × 10-41.1
MPI'8 day' vs '0 day'timeGlobal expression profiling time series of early human embryonic stem cell differentiation towards the mesoderm lineage
Adjusted p-valueLog2-fold change
1.5513 × 10-4-1.1
MPI'DMSO-mediated cell differentiation prior to experiment' vs 'not cultured with DMSO' in 'interferon gamma'compound, growth conditionRNA-microarray analysis of PLB-985 cells cultured with or without interferon-gamma under both conditions that induce or do not induce cell differentiation
Adjusted p-valueLog2-fold change
1.9133 × 10-4-1.1
MPI'phorbol 13-acetate 12-myristate; 100 nanomolar; lipopolysaccharide and interferon gamma; 1 day' vs 'none; none; 0 day'compound, stimulus, timeTranscriptional profiling of THP1-derived human macrophages with different stimuli
Adjusted p-valueLog2-fold change
2.8037 × 10-4-1.1
MPI'COLO 205; adenocarcinoma of colon; P04' vs 'COLO 205; adenocarcinoma of colon; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
7.5229 × 10-41.1
MPI'Hypoxia' vs 'Normoxia' in 'A2780; Cisplatin'cell line, compound, growth conditionAnalysis of gene expression changes in response to hypoxia and/or cisplatin in A2780 and A2780cis cells
Adjusted p-valueLog2-fold change
7.8771 × 10-4-1.1
MPI'shHOXA9; GBML18; ' vs 'control; GBML18; 'RNA interference, cell line, phenotypeHOXA9 transcriptomic analysis in GBM cell lines (U87MG, U251 and primary GBML18) and in immortalized human astrocytes (hTERT/E6/E7)
Adjusted p-valueLog2-fold change
8.0986 × 10-41.1
MPI'astrocyte overexpressing 4 genes' vs 'glioma stem cell line'phenotypeTranscription profiling by array of human primary astrocytes, cancer stem cells derived from astrocytes overexpressing various oncogenic and iPSC-inducing factors, glioma stem cells and gliblastomat cell line to compare their expression profiles and tumor-initiating capabilities
Adjusted p-valueLog2-fold change
2.1302 × 10-31.1
MPI'7 day' vs '0 day'timeGlobal expression profiling time series of early human embryonic stem cell differentiation towards the mesoderm lineage
Adjusted p-valueLog2-fold change
2.1581 × 10-31.1
MPI'deferoxamine; none' vs 'control; none'growth condition, treatmentTranscription profiling by array of human glioblastoma cells after stimulation with deferoxamine and treatment with polyamide 1, echinomycin, or HIF-1a siRNA
Adjusted p-valueLog2-fold change
1.0004 × 10-2-1.1
MPI'hepatobiliary carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
3.1018 × 10-2-1.1
MPI'West Nile Virus protein E domain DIII' at '6 hour' vs 'none' at '0 hour'stimulus, timeTranscriptome analysis of human brain microvascular endothelial cells response to interactive DIII domain of protein E of WNV and interactive DIII domain of protein E of TBEV using RNA-seq
Adjusted p-valueLog2-fold change
3.3253 × 10-2-1.1
ENSG00000178802'COVID-19' vs 'normal' in 'colon'disease, organism partLung and colon transcriptome profiling of fatal COVID-19 cases
Adjusted p-valueLog2-fold change
3.4464 × 10-21.1
MPI'type 1 diabetes clinical onset; pancreas' vs 'normal; pancreas'clinical information, organism partTranscription profiling of human pancreas from patients with type 1 diabetes (clinical onset and longstanding)
Adjusted p-valueLog2-fold change
3.5316 × 10-21.1
MPI'clear cell renal carcinoma' vs 'normal' in 'adult'developmental stage, diseaseGene expression data from human data of different types of renal tumors and normal kidneys
Adjusted p-valueLog2-fold change
3.6098 × 10-21.1
MPI'overexpression of HO-1' vs 'control' in '0 nanogram per milliliter; tumor necrosis factor'compound, phenotypeHO-1 modulates the expression of genes involved in inflammation, angiogenesis, proliferation, apoptosis and cell adhesion in human lung cancer cells.
Adjusted p-valueLog2-fold change
1.7514 × 10-271
MPI'RRx-1; 20 micromolar' vs 'none'compoundRNA-seq of Huh7 cell after G6PD enzyme activity inhibitor RRx-1 treated with 20μM concentrations for 24h
Adjusted p-valueLog2-fold change
4.6434 × 10-19-1
ENSG00000178802'bacteriemia; Staphylococcus aureus' vs 'normal; none'disease, infectGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
2.4639 × 10-141
MPI'KLF17 overexpression' vs 'wild type' at '5 day'phenotype, timeRNA-seq of hESCs undergoing primed to naive-like resetting via exogenous KLF17 overexpression
Adjusted p-valueLog2-fold change
1.0905 × 10-131
MPI'sulforaphane; normal' at '24 hour' vs 'DMSO; normal' at '24 hour'compound, disease, timeGenome-wide transcriptome analysis of the dietary chemopreventive phytochemical sulforaphane on normal and prostate cancer cells.
Adjusted p-valueLog2-fold change
5.6695 × 10-71
MPI'neoplasm' vs 'normal tissue adjacent to neoplasm' in 'smoker; non-obese'clinical history, clinical information, sampling siteSmoking and Obesity Related Molecular Alterations in Clear Cell Renal Cell Carcinoma
Adjusted p-valueLog2-fold change
6.4539 × 10-7-1
MPI'acquired TRAIL-resistance' vs 'control'genotypeGene expression profile of TRAIL-sensitive and -resistant H460 cells
Adjusted p-valueLog2-fold change
9.4299 × 10-61
MPI'NCI-H460; large cell lung carcinoma; P01' vs 'NCI-H460; large cell lung carcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
2.6735 × 10-5-1
MPI'DDX3 siRNA 8' vs 'scrambled siRNA'RNA interferenceExpression profiling of DDX3X and DDX54 knockdown in MCF7 cells
Adjusted p-valueLog2-fold change
3.4038 × 10-5-1
MPI'FOXP3 expression' vs 'doxycycline-mediated repression of FOXP3' in 'control siRNA'RNA interference, phenotypeTranscription profiling by array of human MCF-7 breast cancer cells with FOXP3 target gene expression with and without MOF knockdown
Adjusted p-valueLog2-fold change
5.919 × 10-51
MPI'NCI-H460; large cell lung carcinoma; P10' vs 'NCI-H460; large cell lung carcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
6.0193 × 10-5-1
MPI'SARS coronavirus Urbani ΔORF6 mutant' vs 'mock' at '72 hour'infect, timeTime course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells
Adjusted p-valueLog2-fold change
1.7706 × 10-4-1
MPI'Cisplatin' vs 'None' in 'A2780; Normoxia'cell line, compound, growth conditionAnalysis of gene expression changes in response to hypoxia and/or cisplatin in A2780 and A2780cis cells
Adjusted p-valueLog2-fold change
1.8198 × 10-4-1
MPI'Staphylococcus aureus strain SK2' vs 'none'infectTranscription profiling of human primary bone cells exposed to Staphylococcus aureus
Adjusted p-valueLog2-fold change
2.4532 × 10-41
MPI'brefeldin A' vs 'ethanol' at '20 hour'compound, timeMicroarray analysis of human A549 lung cancer cells treated with brefeldin A, golgicide A, monensin or vehicle control for 8 h or 20 h
Adjusted p-valueLog2-fold change
3.0062 × 10-4-1
MPI'DMSO-mediated cell differentiation during experiment' vs 'not cultured with DMSO' in 'none'compound, growth conditionRNA-microarray analysis of PLB-985 cells cultured with or without interferon-gamma under both conditions that induce or do not induce cell differentiation
Adjusted p-valueLog2-fold change
4.0428 × 10-4-1
MPI'human metapneumovirus' at '72 hour' vs 'none' at '48 hour'infect, timeTranscription profiling by array of human bronchiole epithelial cells infected with human metapneumovirus
Adjusted p-valueLog2-fold change
9.5111 × 10-41
MPI'astrocyte overexpressing 7 genes' vs 'glioblastoma cell line'phenotypeTranscription profiling by array of human primary astrocytes, cancer stem cells derived from astrocytes overexpressing various oncogenic and iPSC-inducing factors, glioma stem cells and gliblastomat cell line to compare their expression profiles and tumor-initiating capabilities
Adjusted p-valueLog2-fold change
9.9882 × 10-41
MPI'MPS-1 shRNA' vs 'control shRNA'RNA interferenceTranscription profiling by array of metallopanstimulin-1 (MPS-1) knock down human gastric cancer cells
Adjusted p-valueLog2-fold change
1.1661 × 10-31
MPI'cultured with 3D BPH-1 epithelial acini' vs 'cultured without epithelial acini'growth conditionTranscription profiling by array of human stromal cells cultured with or without 3D BPH-1 prostate epithelial cells
Adjusted p-valueLog2-fold change
1.2339 × 10-3-1
MPI'liver' vs 'blood' in 'mucosal invariant T cell; Uveal Melanoma'cell type, disease, organism partRNA-seq expression profiling of humain MAIT cells in blood and liver as compared to mainstream TCD4+ and TCD8+ cells.
Adjusted p-valueLog2-fold change
1.4605 × 10-31
MPI'9 day' vs '0 day'timeGlobal expression profiling time series of early human embryonic stem cell differentiation towards the mesoderm lineage
Adjusted p-valueLog2-fold change
2.6872 × 10-31
MPI'hypoxia' vs 'normal atmospheric oxygen pressure' in 'high metastatic cell line'growth condition, phenotypeTranscriptome analysis of pancreatic cancer cell line that differ in metastatic potential
Adjusted p-valueLog2-fold change
5.6051 × 10-3-1
MPI'T-helper 2 polarising' at '5 days' vs 'no stimulus'cell type, sampling time point, stimulusTranscription profiling by array of human CD4+T-cells, Th1/Th2 polarized time-series and primary memory subsets
Adjusted p-valueLog2-fold change
6.9082 × 10-3-1
MPI'tumor necrosis factor alpha' vs 'none' in 'brain microvascular endothelial cell; co-culture'cell type, growth condition, stimulusReactive astrocytes transduce blood-brain barrier inflammation through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
Adjusted p-valueLog2-fold change
1.8074 × 10-21
MPI'48 hour' vs '0 hour' in 'cytomegalovirus infection'timeTranscriptome modulation analysis of cytomegalovirus-infected immature monocyte-derived dendritic cells
Adjusted p-valueLog2-fold change
2.4056 × 10-21
MPI'intravenous immunoglobulin and methylprednisolone' vs 'none' in 'intravenous immunoglobulin resistant'clinical treatment, phenotypeTranscription profiling by array of human peripheral blood samples from Kawasaki disease patients after treatment with intravenous immunoglobulin and methylprednisolone
Adjusted p-valueLog2-fold change
3.2738 × 10-2-1
MPI'U87MG; MSCV-HOXA9' vs 'U87MG; control'RNA interference, cell line, phenotypeHOXA9 transcriptomic analysis in GBM cell lines (U87MG, U251 and primary GBML18) and in immortalized human astrocytes (hTERT/E6/E7)
Adjusted p-valueLog2-fold change
3.4052 × 10-4-0.6
ENSG00000178802'Alzheimer's disease' vs 'normal' in 'octogenarian age bracket'disease, clinical informationProteomics of Brain Proteome Revealed Altered Mitochondrial Function in Alzheimer Disease
Ortholog
MPI (Macaca mulatta), MPI (Equus caballus), ENSOCUG00000008149 (Oryctolagus cuniculus), C05C8.7 (Caenorhabditis elegans), mpi (Tetraodon nigroviridis), MPI (Monodelphis domestica), ZK632.4 (Caenorhabditis elegans), PMI40 (Saccharomyces cerevisiae), MPI (Dasypus novemcinctus), Mpi (Drosophila melanogaster), MPI (Bos taurus), ENSCING00000005335 (Ciona intestinalis), MPI (Sus scrofa), MPI (Ornithorhynchus anatinus), Mpi (Mus musculus), mpi (Danio rerio), MPI (Pan troglodytes), MPI (Chlorocebus sabaeus), MPI (Pongo abelii), ENSACAG00000017077 (Anolis carolinensis), ENSOARG00020023529 (Ciona savignyi), MPI (Anas platyrhynchos), ENSACAG00000004579 (Anolis carolinensis), ENSCSAVG00000006194 (Ciona savignyi), Mpi (Rattus norvegicus), mpi (Xenopus tropicalis), MPI (Gorilla gorilla), MPI (Papio anubis), MPI (Gallus gallus)
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
Gene biotype
Design element
A_23_P60579, Hs.75694.1.S1_3p_at, 202472_PM_at, 3601959, 3601958, 3601957, 3601979, 3601956, 3601977, 16803103, 3601975, 3601974, 3601973, g4505234_3p_at, 3601972, 3601971, 3601970, 36673_at, X76057_at, 4351_at, 11761481_a_at, 57208_at, 11744376_a_at, 230524_at, 11759552_at, 3601969, 230524_PM_at, 3601968, 3601966, 3601965, 3601964, 3601963, 3601985, 3601962, 3601961, 3601983, 11761482_x_at, 3601960, 3601981, 7984922, g4505234_3p_x_at, 11760741_a_at, ILMN_1761262, 202472_at
Reactome pathway ID