ENSMUSG00000020323 (Prss57)

mus musculus

protease, serine 57

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Mus musculus
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Showing 9 experiments:
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Created with Highcharts 6.2.0brainbrown adipose tissuecaudal brain neural epitheliumcentral neural epitheliumcolondentate gyrus of hippocampal formationdorsal control neural epitheliumepidermal ectodermfloor platehead mesenchymeheartkidneylateral nasal prominencelateral prominence neural epitheliumliverlungmandibular archmaxillary archmedial nasal prominencemesodermnon-floor plate neural epitheliumolfactory bulbolfactory pitskeletal muscle tissuespleenstriatumsubventricular zonetestisthymuswhite adipose tissuezone of skin
T
14 - embryonic day 10.5
T
9 in 3 strains - DBA/2J
T
14 - embryonic day 8.5
T
Fat and muscle
T
9 in 3 strains - CD1
T
9 in 3 strains - C57BL/6
T
9
T
4
T
14 - embryonic day 9.5
P
Proteomics
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Transcriptomics
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Regulation
-1
-8.1
1
5.6
Display log2-fold change
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
1.3435 × 10-12-8.1
Prss57'5 week' vs '1 week' in 'Jak2+/V617F; CRISPR/Cas9 mediated knockout of Dnmt3a'genotype, timeRNA-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls one week and five weeks post methylcellulose plating
Adjusted p-valueLog2-fold change
2.3429 × 10-7-7.3
Prss57'SMRT shRNA; CpG; 6 hour' vs 'none; none; 0 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
2.4699 × 10-215.6
Prss57'α-GalCer; 2 microgram' vs 'none' in 'Cd1d homozyous knockout'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
2.1713 × 10-5-5.5
Prss57'CpG; 6 hour' vs 'none; 0 hour' in 'none'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
1.7304 × 10-154.6
Prss57'cancer' vs 'normal' in 'lymph node subcapsular sinus macrophage'cell type, diseaseRNA Sequencing of CD169+ lymph node macrophages isolated from naïve or tumor-bearing mice
Adjusted p-valueLog2-fold change
1.0875 × 10-6-4.4
Prss57'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
5.6815 × 10-64.4
Prss57'myeloid lineage restricted progenitor cell' vs 'long term hematopoietic stem cell' in 'Elp3fl/fl'cell type, genotypeRNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
Adjusted p-valueLog2-fold change
8.6846 × 10-6-4.4
Prss57'SMRT shRNA' vs 'none' in 'none' at '0 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
2.6213 × 10-103.9
Prss57'Id2_Id3_double knockout' vs 'wild type' in 'CD4+TCRb+CD8– cell; thymus'cell type, genotype, organism partTranscription profiling by high throughput sequencing of Id-proteins (Id2 and Id3) gene knockout cells
Adjusted p-valueLog2-fold change
3.7584 × 10-5-3.8
Prss57'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.2393 × 10-153.6
Prss57'Triple knockout (Zfp36-/-, TNFR1-/-, TNFR2-/-)' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of douple (TNFR1-/-/TNFR2-/-) and triple (Zfp36-/-/TNFR1-/-/TNFR2-/-) knockout mouse spleens
Adjusted p-valueLog2-fold change
2.084 × 10-83.4
Prss57'MEF2C/D knockout' vs 'wild type genotype' in 'primary cell line; none'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.6868 × 10-6-3.4
Prss57'synovial sarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
1.6933 × 10-63.3
Prss57'MEF2C/D knockout' vs 'wild type genotype' in 'primary cell line; lipopolysaccharide; 10 nanogram per milliliter'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.7121 × 10-133.1
Prss57'3110043O21Rik knockout; spleen' vs 'wild type genotype; spleen'genotype, organism part, sampling siteRNAseq of coding RNA in the liver, spleen, kidney, abdominal muscle and gonadal adipose tissue of knock out mice and wild type controls.
Adjusted p-valueLog2-fold change
2.7071 × 10-73
Prss57'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'classical monocyte'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
8.4116 × 10-172.9
Prss57'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'endothelial cell; expressing AKT1'cell type, growth condition, phenotypeTranscription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture
Adjusted p-valueLog2-fold change
3.0105 × 10-22.8
Prss57'hepatocyte-derived proliferative ducts (hepPDs)' vs 'hepatocyte'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
1.1329 × 10-152.6
Prss57'Cd1d homozyous knockout' vs 'wild type genotype' in 'α-GalCer; 2 microgram'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
1.6195 × 10-32.6
Prss57'MEF2C/D knockout' vs 'wild type genotype' in 'primary cell line; lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.8301 × 10-3-2.6
Prss57'carotid body' vs 'adrenal medulla'organism partExpression profile of mouse carotid body and adrenal medulla [RNA-Seq]
Adjusted p-valueLog2-fold change
9.8112 × 10-32.5
Prss57'p150 subunit of CAF-1 siRNA knockdown' vs 'scrambled siRNA'RNA interferenceRNA-seq of control siRNA, p150 siRNA and p60 siRNA transfected mES cells
Adjusted p-valueLog2-fold change
3.9071 × 10-22.5
Prss57'uterine-specific Tsc2-null' vs 'wild type' in '17beta-estradiol'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
1.8271 × 10-2-2.4
Prss57'osteosarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
3.1168 × 10-6-2.3
Prss57'erythroblast' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
8.1757 × 10-5-2.3
Prss57'megakaryocyte' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
1.3208 × 10-32.2
Prss57'promyelocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
2.3577 × 10-22.2
Prss57'p60 subunit of CAF-1 siRNA knockdown' vs 'scrambled siRNA'RNA interferenceRNA-seq of control siRNA, p150 siRNA and p60 siRNA transfected mES cells
Adjusted p-valueLog2-fold change
4.7679 × 10-2-2.2
Prss57'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.5949 × 10-42.1
Prss57'MEF2C/D knockout' vs 'wild type genotype' in 'primary cell line; prostaglandin E2; 1 micromolar'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.0439 × 10-22.1
Prss57'doxorubicin; 17.5 milligram per kilogram body weight' vs 'vehicle' in 'scramble; podocyte'cell type, compound, genotypeTranscription profiling to identify the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin
Adjusted p-valueLog2-fold change
1.7219 × 10-2-2
Prss57'LDB1 knock-down with full-length Ldb1 construct' vs 'control shRNA'RNA interferenceRole of LDB1 in the transition from chromatin looping to transcription activation
Adjusted p-valueLog2-fold change
1.6392 × 10-2-1.9
Prss57'undifferentiated' vs 'differentiated; rosiglitazone' in 'C57BL/6J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.1141 × 10-8-1.8
Prss57'Col1a1-tetO-MLL/ENL' vs 'wild type' in 'precursor for granulocyte-macrophage progenitor cell'cell type, genotypeTranscription profiling by high throughput sequencing of hematopoietic stem cells from a conditional-inducible mouse model of the MLL-ENL fusion oncogene
Adjusted p-valueLog2-fold change
3.38 × 10-4-1.7
Prss57'hematopoietic stem cell and hematopoietic multipotent progenitor cell' vs 'common myeloid progenitor'cell typeTranscription profiling by high throughput sequencing between multipotent hematopoietic stem progenitor cells LS+K) and myeloid committed cells (LS−K) of the mouse bone marrow
Adjusted p-valueLog2-fold change
3.5406 × 10-2-1.6
Prss57'LDB1 knock-down with Ldb1 delta 4/5 construct' vs 'control shRNA'RNA interferenceRole of LDB1 in the transition from chromatin looping to transcription activation
Adjusted p-valueLog2-fold change
1.5712 × 10-2-1.5
Prss57'CD4-positive T cell' vs 'CD8-positive T cell' in 'Egr2-GFP knockin; Egr2-GFP high'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
1.4006 × 10-5-1.4
Prss57'pre-B acute lymphoblastic leukemia 8093; nilotinib; 3 day' vs 'pre-B acute lymphoblastic leukemia 8093; nilotinib; 0 day'cell type, compound, timeDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Adjusted p-valueLog2-fold change
3.9742 × 10-81.2
Prss57'26 day' vs '0 day'ageGene expression profile of mouse differentiating embryonic stem cells (day 0, 6, 16, and 26)
Adjusted p-valueLog2-fold change
1.0249 × 10-31.2
Prss57'plasmacytoid dendritic cell; Ifnar1 knock out; specific pathogen free' vs 'plasmacytoid dendritic cell; wild type genotype; specific pathogen free'cell type, genotype, growth conditionRNA sequencing of primary isolated unstimulated murine splenic DC1 and DC2 from specific pathogen free (SPF), Germ free (GF) and Interferon alpha/beta receptor 1 (Ifnar) knock out mice
Adjusted p-valueLog2-fold change
4.7641 × 10-21.2
Prss57'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'stromal cell; expressing AKT1'cell type, growth condition, phenotypeTranscription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture
Adjusted p-valueLog2-fold change
1.3462 × 10-5-1.1
Prss57'Cd1d homozyous knockout' vs 'wild type genotype' in 'none'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
8.0638 × 10-3-1.1
Prss57'Lmp7-/-Mecl1-/-' vs 'wild type'genotypeEffect of LMP7 and MECL1-immunoproteasome subunits deficiency on the transcriptome of mouse bone marrow-derived dendritic cells
Adjusted p-valueLog2-fold change
4.1687 × 10-2-1.1
Prss57'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
3.8762 × 10-31
Prss57'Cbs knockout' vs 'wild type'genotypeGene expression profile of CD4-positive T cells from mouse Cbs knockout
Adjusted p-valueLog2-fold change
1.496 × 10-2-1
Prss57'Pabpn1 knockdown by shRNA' vs 'scrambled shRNA'genotype3' RNA-seq of Pabpn1 knockdown in mouse Lin- Kit+ bone marrow cells
Adjusted p-valueLog2-fold change
1.9306 × 10-21
Prss57'acute myeloid leukemia' vs 'myeloproliferative disorder'diseaseTranscription profiling by high throughput sequencing of c-KIT+ splenocytes from murine acute myeloid leukemia and myeloproliferative neoplasm
Adjusted p-valueLog2-fold change
4.5697 × 10-2-1
Prss57'4-oxoretinoic acid; 5 micromolar' vs 'none' in 'Rarb -/-'compound, genotypeRNA Seq of wildtype and Rarb KO HSCs after 24h of in vitro culture and treatment