ENSMUSG00000031174 (Rpgr)

mus musculus

retinitis pigmentosa GTPase regulator

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Mus musculus
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Showing 54 experiments:
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Created with Highcharts 6.2.0adrenal glandcentral neural epitheliumepidermal ectodermhippocampusmammary glandolfactory epitheliumsmall intestineuterusaxillary lymph nodebronchuscorpora quadrigeminadiencephalonfloor plateheartintestinal mucosalateral prominence neural epitheliummedial prefrontal cortexmuscle tissuepancreasprostate glandstriatumthymuswhite adipose tissue
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49 FANTOM5 project - adult
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49 FANTOM5 project - neonate
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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49 FANTOM5 project - embryonic day 12
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9 in 3 strains - C57BL/6
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14 - embryonic day 10.5
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49 FANTOM5 project - embryonic day 13
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Mammalian Kaessmann
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Vertebrates
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14 - embryonic day 9.5
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14 - embryonic day 8.5
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4 Bonthuis et al - CastEiJ
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4 Bonthuis et al - (CastEiJ X …
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4 Bonthuis et al - (C57BL/6J X …
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Fat and muscle
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Developing gut
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49 FANTOM5 project - embryonic day 11
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3 Soumillon et al
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Sun et al., 2020 - Organism part
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - C57BL/6J
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Mernberger et al 2019 - Organism Part
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 14.5
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49 FANTOM5 project - embryo
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4 Bonthuis et al - Idaho derived wild …
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Organism part - Huttlin et al
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Linscheid et al., 2021 - tissue - heart …
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Huttlin et al., 2010 - tissues - brain, …
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Duda et al., 2018 - organism part - …
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Linscheid et al. 2019 - organism part
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Deshmukh et al., 2015 - organism part
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Proteomics
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Transcriptomics
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Kingdom
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Experimental variables
Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
3.2892 × 10-5-6.4
Rpgr'Zbtb10 knockdown' vs 'control' at '2 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
3.0475 × 10-4-5.7
Rpgr'Zbtb10 knockdown' vs 'control' at '6 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
9.3118 × 10-53.7
Rpgr'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
7.8067 × 10-7-3.2
Rpgr'metaphase II oocyte' vs 'germinal vesicle oocyte'cell typeTranscription profiling of mouse in vivo matured MII oocytes and fully in vivo grown germinal vesicle oocytes to identify gene transcripts linked to epigenetic reprogramming
Adjusted p-valueLog2-fold change
1.05 × 10-42.7
Rpgr'MEF2A knockout' vs 'wild type genotype' in 'Hoxb8-FL; lipopolysaccharide; 10 nanogram per milliliter'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.2233 × 10-62.4
Rpgr'BCL6 knockout and inducible BACH2 overexpression' vs 'wild type and inducible BACH2 overexpression'genotypeGene expression profile of BCR-ABL1 transformed pre-B mouse cells from BCL6 knockout after inducible overexpression of Bach2
Adjusted p-valueLog2-fold change
7.6699 × 10-32.4
Rpgr'Yersinia pestis' vs 'control' in 'neutrophil'cell type, infect, sampling siteSpatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague
Adjusted p-valueLog2-fold change
7.519 × 10-132.2
Rpgr'hepatocyte-derived proliferative ducts (hepPDs)' vs 'hepatocyte'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
1.0256 × 10-4-2.2
Rpgr'Lkb1 -/- Pten-/-' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
2.5247 × 10-42.1
Rpgr'MEF2A knockout' vs 'wild type genotype' in 'Hoxb8-FL; none'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.8955 × 10-62
Rpgr'transplanted secondary tumors' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
7.2841 × 10-5-1.9
Rpgr'pre-B acute lymphoblastic leukemia Bin2; lonafarnib; 30 day' vs 'pre-B acute lymphoblastic leukemia Bin2; lonafarnib; 0 day'cell type, compound, timeDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Adjusted p-valueLog2-fold change
4.0549 × 10-4-1.9
Rpgr'Kras G12D' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
1.122 × 10-21.9
Rpgr'SMRT shRNA' vs 'none' in 'CpG' at '6 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
2.0876 × 10-81.8
Rpgr'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
6.5996 × 10-41.8
Rpgr'V6.5; embryonic stem cell’ vs 'wild type; endothelial'cell line, cell type, genotypeCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Adjusted p-valueLog2-fold change
1.273 × 10-6-1.7
Rpgr'granulocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
4.8185 × 10-4-1.7
Rpgr'postnatal 2-3 month; hindlimb' vs 'embryonic day 17.5; whole forelimb and hindlimb'age, organism partExpression data from skeletal muscle satellite cells at different development stages
Adjusted p-valueLog2-fold change
1.3491 × 10-31.7
Rpgr'tumor' vs 'normal' in 'liver'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
2.1319 × 10-71.6
Rpgr'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
3.1339 × 10-2-1.6
Rpgr'human chorionic gonadotropin; 5 International Unit' vs 'none' in 'bER knockout'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
4.7857 × 10-21.5
Rpgr'SMRT shRNA' vs 'none' in 'none' at '0 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
5.6225 × 10-9-1.4
Rpgr'Kit ligand' vs 'none' in 'wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
5.7574 × 10-31.4
Rpgr'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
1.8773 × 10-101.3
Rpgr'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.3008 × 10-51.3
Rpgr'UPF2 knockout' vs 'wild type'phenotypeMicroarray profiling of mouse pachytene cells deficient for UPF2 or both TUT4 and TUT7
Adjusted p-valueLog2-fold change
3.7776 × 10-4-1.3
Rpgr'pre-B acute lymphoblastic leukemia 8093; nilotinib; 3 day' vs 'pre-B acute lymphoblastic leukemia 8093; nilotinib; 0 day'cell type, compound, timeDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Adjusted p-valueLog2-fold change
4.2706 × 10-4-1.3
Rpgr'postnatal >1 year; hindlimb' vs 'embryonic day 17.5; whole forelimb and hindlimb'age, organism partExpression data from skeletal muscle satellite cells at different development stages
Adjusted p-valueLog2-fold change
4.9007 × 10-41.3
Rpgr'alpha-amanitin; maternal Ring1-Rnf+' vs 'none; maternal Ring1-Rnf+'compound, genotypePolycomb function during oogenesis is required for mouse early embryonic development (2-cell embryos)
Adjusted p-valueLog2-fold change
2.4132 × 10-31.3
Rpgr'chemical hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to chemical hypoxia in vivo.
Adjusted p-valueLog2-fold change
5.0709 × 10-31.3
Rpgr'synovial sarcoma' vs 'normal'diseaseTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
Adjusted p-valueLog2-fold change
1.0125 × 10-21.3
Rpgr'conditional UPF2 knockout; 36 hour after partial hepatechtomy' vs 'control; 36 hour after partial hepatechtomy'genotype, sampling timeTranscription profiling of livers of adult UPF2 null mice in response to partial hepatechtomy
Adjusted p-valueLog2-fold change
1.7961 × 10-21.3
Rpgr'dorsolateral nucleus motor neuron' vs 'lumbar motor neurons'cell typeComparison of gene expression in motor pools with differential vulnerability in ALS
Adjusted p-valueLog2-fold change
1.8197 × 10-6-1.2
Rpgr'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
3.5601 × 10-4-1.2
Rpgr'shRNA mediated Brd4 knockdown' vs 'control shRNA'treatmentExpression Data For BRD4 Inhibition
Adjusted p-valueLog2-fold change
5.8826 × 10-41.2
Rpgr'5,9-endoperoxy-cholest-7-en-3β,6α-diol' vs 'vehicle (cyclodextrin)'compound, timeArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
Adjusted p-valueLog2-fold change
6.4122 × 10-3-1.2
Rpgr'AZD5069; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
2.1367 × 10-2-1.2
Rpgr'induction of polymicrobial sepsis' vs 'control' at '2 hour' in '1.5 to 3 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
3.1065 × 10-2-1.2
Rpgr'PTEN null, P53-/-' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
5.5323 × 10-8-1.1
Rpgr'K14-Cre-ERT2; none; UVB irradiation; 7 day' vs 'K14-Cre-ERT2; none; none'genotype, irradiate, timeAblation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin
Adjusted p-valueLog2-fold change
1.2365 × 10-61.1
Rpgr'NrlGFP positive' vs 'NrlGFP negative'phenotypeTranscription profiling by array of photoreceptor precursor cells selected via cell surface antigen expression.
Adjusted p-valueLog2-fold change
2.9349 × 10-6-1.1
Rpgr'none; wasp knockout' vs 'none; wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
3.0542 × 10-6-1.1
Rpgr'Chikungunya virus; late stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
1.4417 × 10-5-1.1
Rpgr'Lymphocytic choriomeningitis mammarenavirus' vs 'none' in 'wild type genotype'genotype, infectComparison of Trail+/+ versus Trail-/- splenic NK cells from naïve and LCMV-infected mice
Adjusted p-valueLog2-fold change
4.2911 × 10-51.1
Rpgr'tristetrapolin knockout' vs 'wild type' in 'actinomycin D' at '120 minute'compound, genotype, timeTranscription profiling by array of fibroblasts from TTP knock out mice
Adjusted p-valueLog2-fold change
4.1415 × 10-4-1.1
Rpgr'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.2466 × 10-31.1
Rpgr'L-Pex5 knock-out' vs 'wild type'genotypeTranscription profiling by array of liver from L-Pex5 knock-out mice
Adjusted p-valueLog2-fold change
2.2415 × 10-2-1.1
Rpgr'5 week' vs '1 week' in 'Jak2+/V617F; CRISPR/Cas9 mediated knockout of Dnmt3a'genotype, timeRNA-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls one week and five weeks post methylcellulose plating
Adjusted p-valueLog2-fold change
2.9787 × 10-81
Rpgr'tape stripping and oral administration of winged bean extract' vs 'tape stripping'treatmentTranscription profiling by array of mouse dorsal skin after tape stripping and treatment with winged bean extract.
Adjusted p-valueLog2-fold change
5.2934 × 10-8-1
Rpgr'Lymphocytic choriomeningitis mammarenavirus' vs 'none' in 'TRAIL homozygous knock out'genotype, infectComparison of Trail+/+ versus Trail-/- splenic NK cells from naïve and LCMV-infected mice
Adjusted p-valueLog2-fold change
8.6021 × 10-7-1
Rpgr'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.129xB6'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
5.0088 × 10-51
Rpgr'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
9.75 × 10-5-1
Rpgr'postnatal day 21; hindlimb' vs 'embryonic day 17.5; whole forelimb and hindlimb'age, organism partExpression data from skeletal muscle satellite cells at different development stages
Adjusted p-valueLog2-fold change
5.8718 × 10-41
Rpgr'Alkbh1-/-' vs 'wild type'genotypeTranscription profiling by array of wild type and Alkbh1 knock out mouse embyronic stem cells
Adjusted p-valueLog2-fold change
3.632 × 10-31
Rpgr'Helicobacter hepaticus' vs 'none' in 'Alpk1 homozygous knockout'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
9.5209 × 10-3-1
Rpgr'West Nile virus; early stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
1.0646 × 10-21
Rpgr'conditional UPF2 knockout; before partial hepatechtomy' vs 'control; before partial hepatechtomy'genotype, sampling timeTranscription profiling of livers of adult UPF2 null mice in response to partial hepatechtomy
Adjusted p-valueLog2-fold change
1.3943 × 10-21
Rpgr'Albumin Cre+/-;Hnf4a fl/fl' vs 'wild type genotype'genotypeTranscription profiling by array of liver-specific Hnf4alpha knock-out mice
Adjusted p-valueLog2-fold change
2.8733 × 10-2-1
Rpgr'120 day; Sod1 G93A' vs '120 day; wild type genotype'age, genotypeTranscription profiling of astrocytes from the symptomatic and late-stage time points of the SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS)
Adjusted p-valueLog2-fold change
3.2077 × 10-2-1
Rpgr'lipopolysaccharide; 10 nanogram per milliliter and PFI-1; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Synonym
Rp3h, Rd9
Ortholog
RPGR (Anas platyrhynchos), RPGR (Macaca mulatta), Rcc1 (Drosophila melanogaster), RPGR (Dasypus novemcinctus), ENSPTRG00000052456 (Pan troglodytes), ENSMODG00000021106 (Monodelphis domestica), ENSMMUG00000059272 (Macaca mulatta), RPGR (Equus caballus), ENSSSCG00000012235 (Sus scrofa), RPGR (Gallus gallus), RPGR (Tetraodon nigroviridis), RPGR (Anolis carolinensis), ENSCSAVG00000001978 (Ciona savignyi), ENSPTRG00000049249 (Salmo salar), Rpgr (Rattus norvegicus), ENSOANG00000007117 (Ornithorhynchus anatinus), rpgra (Danio rerio), RPGR (Homo sapiens), ca (Drosophila melanogaster), ENSCING00000006287 (Salmo salar), RPGR (Oryctolagus cuniculus), ENSCING00000018304 (Salmo salar), CG7420 (Drosophila melanogaster), RPGR (Bos taurus), ENSPPYG00000020017 (Bos taurus), rpgrb (Danio rerio), ENSPPYG00000020245 (Pongo abelii), FMP25 (Saccharomyces cerevisiae), ENSGGOG00000023793 (Gorilla gorilla), ran-3 (Caenorhabditis elegans), SRM1 (Saccharomyces cerevisiae)
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
5463870, 5593695, 1427467_a_at, 5089487, 5575060, 4420052, ILMN_1248760, ILMN_2703093, 4824722, 95550_at, 4577448, 5078013, 5009938, 4643159, A_55_P1968824, 4903843, 5576021, A_55_P1968828, 4588084, ILMN_2820877, A_55_P1968833, A_51_P209914, 5138280, 5600125, 10603598, 4935933, 4872471, 17540203, 4492568, 4360602, ILMN_2497259, 5277121, 4737692, 4396480, 5046330, A_55_P2114482, A_52_P365294, A_52_P365292, ILMN_1244805, 4944749, 4562490, 5445231, 5468773, 4626201, 4906454, 4670640, 5051969, 5476549, 5264062, 4934745