ENSMUSG00000035392 (Dennd1a)

mus musculus

DENN/MADD domain containing 1A

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Mus musculus
Organism part
Showing 48 experiments:
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Created with Highcharts 6.2.0adrenal glandaxillary lymph nodebronchuscentral neural epitheliumcorpora quadrigeminadifferentiated myotubeepididymisforelimbhippocampal formationintestinal mucosalateral prominence neural epitheliummandibular archmedulla oblongatanon-floor plate neural epitheliumolfactory pitpituitary glandskeletal muscle tissuestomachtestisurinary bladdervomeronasal organzone of skin
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49 FANTOM5 project - adult
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49 FANTOM5 project - neonate
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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9
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49 FANTOM5 project - embryonic day 12
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9 in 3 strains - C57BL/6
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14 - embryonic day 10.5
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49 FANTOM5 project - embryonic day 13
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Mammalian Kaessmann
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6
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Vertebrates
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4
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14 - embryonic day 9.5
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14 - embryonic day 8.5
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4 Bonthuis et al - CastEiJ
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4 Bonthuis et al - (CastEiJ X …
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4 Bonthuis et al - (C57BL/6J X …
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Fat and muscle
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Developing gut
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49 FANTOM5 project - embryonic day 11
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3 Soumillon et al
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3
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Sun et al., 2020 - Organism part
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - C57BL/6J
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Mernberger et al 2019 - Organism Part
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - lactating adult …
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 14.5
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49 FANTOM5 project - embryo
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4 Bonthuis et al - Idaho derived wild …
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Deshmukh et al., 2015 - organism part
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Proteomics
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Transcriptomics
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-1
-2.3
1
3.1
Display log2-fold change
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
2.3528 × 10-43.1
Dennd1a'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
2.7862 × 10-52.5
Dennd1a'alpha-amanitin; maternal Ring1-Rnf+' vs 'none; maternal Ring1-Rnf+'compound, genotypePolycomb function during oogenesis is required for mouse early embryonic development (2-cell embryos)
Adjusted p-valueLog2-fold change
8.6512 × 10-22-2.3
Dennd1a'3D culture' vs '2D culture'growth conditionmRNA-seq of mouse salivary gland cancer cells cultured in adherent or non-adherent culture
Adjusted p-valueLog2-fold change
7.4679 × 10-42
Dennd1a'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
8.4547 × 10-4-2
Dennd1a'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'wild type'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
1.6568 × 10-3-2
Dennd1a'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'HdhQ111 knock-in'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
1.0679 × 10-22
Dennd1a'neural stem cell' vs 'niche cell'cell typeTranscription profiling by high throughput sequencing of three populations of primary dentate gyrus cells
Adjusted p-valueLog2-fold change
6.5568 × 10-10-1.9
Dennd1a'MEF2A knockout' vs 'wild type genotype' in 'Hoxb8-FL; lipopolysaccharide; 10 nanogram per milliliter'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.4371 × 10-21-1.8
Dennd1a'K14-Cre-ERT2; none; UVB irradiation; 7 day' vs 'K14-Cre-ERT2; none; none'genotype, irradiate, timeAblation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin
Adjusted p-valueLog2-fold change
3.8013 × 10-52-1.7
Dennd1a'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
2.8232 × 10-161.6
Dennd1a'adenoviral vector expressing human ACE2' vs 'empty adenoviral vector'genotypeRNA-seq of SARS-CoV-2 infected lungs from mice sensitized for SARS-CoV-2 infection by Ad5-hACE2 transduction compared to non-sensitized mice
Adjusted p-valueLog2-fold change
1.1941 × 10-71.6
Dennd1a'myeloid lineage restricted progenitor cell' vs 'long term hematopoietic stem cell' in 'Elp3fl/fl'cell type, genotypeRNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
Adjusted p-valueLog2-fold change
4.1806 × 10-51.6
Dennd1a'lipopolysaccharide; 100 nanogram per milliliter and interferon gamma 20 nanogram per milliliter' vs 'none'stimulusTranscriptional profiling in macrophages in stimulated and unstimulated conditions.
Adjusted p-valueLog2-fold change
4.3775 × 10-1021.5
Dennd1a'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
7.2917 × 10-301.5
Dennd1a'lipopolysaccharide; 10 nanogram per milliliter and PFI-1; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.4207 × 10-3-1.5
Dennd1a'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
4.5738 × 10-31.5
Dennd1a'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
1.5163 × 10-291.4
Dennd1a'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
5.9063 × 10-251.4
Dennd1a'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar and interferon beta; 100 units per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
6.3465 × 10-12-1.4
Dennd1a'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.9631 × 10-4-1.4
Dennd1a'actinomycin D; 4 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
8.5733 × 10-11-1.3
Dennd1a'CD36 knockout' vs 'wild type genotype' in 'oxidized low density lipoprotein; 25 microgram per milliliter'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
4.5909 × 10-51.3
Dennd1a'erythroblast' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
4.7403 × 10-5-1.3
Dennd1a'Lkb1 -/- Pten-/-' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
1.276 × 10-41.3
Dennd1a'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
7.1751 × 10-11-1.2
Dennd1a'tamoxifen induction at 2 months, wait 6 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
4.0046 × 10-34-1.1
Dennd1a'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
3.7479 × 10-5-1.1
Dennd1a'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
8.3086 × 10-51.1
Dennd1a'Lactobacillus acidophilus NCFM and Bifidobacterium bifidum Z9' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
3.1431 × 10-4-1.1
Dennd1a'granulocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
3.9436 × 10-3-1.1
Dennd1a'unilateral ureteral obstruction' vs 'sham' in 'TIMP3 -/-'genotype, treatmentTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Adjusted p-valueLog2-fold change
4.4182 × 10-2-1.1
Dennd1a'dexamethasone; 10 microgram per milliliter' vs 'none'compoundRNA-seq of mouse sciatic peripheral nerve of injured mouse with implant: control (untreated) vs local delivery of MCC950 (NLRP3inh) vs standard FBR treatment dexamethasone (Dex). .
Adjusted p-valueLog2-fold change
1.289 × 10-281
Dennd1a'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
4.0524 × 10-17-1
Dennd1a'Tumor Necrosis Factor' vs 'none'stimulusTranscription profiling by high throughput sequencing of CD8 single positive thymocytes from F5 Rag1KO TCR transgenic mice stimulated with tumor necrosis factor
Adjusted p-valueLog2-fold change
2.3586 × 10-71
Dennd1a'reduced expression of miR-25' vs 'wild type'phenotypeTranscription profiling by high throughput sequencing of wild type and miR-25 agomir or antagomir treated mice
Adjusted p-valueLog2-fold change
8.9032 × 10-51
Dennd1a'pkd1 knockout' vs 'wild type' in 'presence of fluid flow'genotype, stimulusTranscription profiling by array of mouse kidney epithelial cells from pkd1 knockout and wild type in response to fluid flow
Adjusted p-valueLog2-fold change
2.384 × 10-4-1
Dennd1a'Ercc1 knock out' vs 'wild type'genotypeTranscription profiling by array of liver from mice mutant for Ercc1
Adjusted p-valueLog2-fold change
6.6405 × 10-4-1
Dennd1a'tumor' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
6.7449 × 10-41
Dennd1a'pkd1 knockout' vs 'wild type' in 'absence of fluid flow'genotype, stimulusTranscription profiling by array of mouse kidney epithelial cells from pkd1 knockout and wild type in response to fluid flow
Adjusted p-valueLog2-fold change
6.7495 × 10-3-1
Dennd1a'Zfx fl/y CreER; infected with control retrovirus with GFP selectable marker' vs 'wild type; infected with control retrovirus with GFP selectable marker'genotype, treatmentEffect of genetic Zfx deletion on Myc induced gene expression in bone marrrow myeloid progenitors
Adjusted p-valueLog2-fold change
1.043 × 10-2-1
Dennd1a'actinomycin D; 8 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Synonym
6030446I19Rik
Ortholog
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
5190436, 4388034, 4998044, 5443588, 4668401, A_51_P146449, 4322194, 4556779, 10482200, 5407933, 5463628, A_51_P146443, 5396794, 4448581, 4352362, 5025280, 5244257, 5324591, 4319821, 4435941, 5231584, 5089572, 5228067, 4820954, 4507827, 4778915, 4686572, 5534183, 4909755, 5554462, 4727366, 5132856, 5291868, 4434243, 4782702, 5162613, 4391677, 116931_at, 5067754, A_55_P1980551, 4339438, 4746534, 5018945, 4645118, 4963764, 4647288, 5576202, ILMN_2713879, 5287246, 17384659, 5025348, 4753975, 5132486, 1424625_a_at
Reactome pathway ID