ENSMUSG00000049265 (Kcnk3)

mus musculus

potassium channel, subfamily K, member 3

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Mus musculus
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Showing 53 experiments:
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Created with Highcharts 6.2.0adrenal glandcentral neural epitheliumepidermal ectodermhippocampusmammary glandolfactory epitheliumsmall intestineuterusaxillary lymph nodebronchuscorpora quadrigeminadiencephalonfloor plateheartintestinal mucosalateral prominence neural epitheliummedial prefrontal cortexmuscle tissuepancreasprostate glandstriatumthymuswhite adipose tissue
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49 FANTOM5 project - adult
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49 FANTOM5 project - neonate
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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49 FANTOM5 project - embryonic day 12
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9 in 3 strains - C57BL/6
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14 - embryonic day 10.5
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49 FANTOM5 project - embryonic day 13
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Mammalian Kaessmann
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Vertebrates
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14 - embryonic day 9.5
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14 - embryonic day 8.5
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4 Bonthuis et al - CastEiJ
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4 Bonthuis et al - (CastEiJ X …
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4 Bonthuis et al - (C57BL/6J X …
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Fat and muscle
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Developing gut
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49 FANTOM5 project - embryonic day 11
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3 Soumillon et al
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Sun et al., 2020 - Organism part
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - C57BL/6J
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Mernberger et al 2019 - Organism Part
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 14.5
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49 FANTOM5 project - embryo
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4 Bonthuis et al - Idaho derived wild …
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Huttlin et al., 2010 - tissues - brain, …
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Linscheid et al., 2021 - tissue - heart …
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Linscheid et al. 2019 - organism part
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Deshmukh et al., 2015 - organism part
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Experimental variables
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
2.5758 × 10-214-9.5
Kcnk3'Irx3 knockout' vs 'control' at '7 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
1.0367 × 10-3-8.1
Kcnk3'Cox6a2 knockout' vs 'wild type'phenotypeRNA-seq of PV+ interneurons in WT and Cox6a2-/- mice to unravel the molecular signaling that contributes to the increase in oxidative stress and metabolic dysregulation following Cox6a2 knockout.
Adjusted p-valueLog2-fold change
2.0162 × 10-20-7.4
Kcnk3'PTEN null, P53-/-' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
2.9027 × 10-8-6.6
Kcnk3'myeloid lineage restricted progenitor cell' vs 'long term hematopoietic stem cell' in 'Elp3fl/fl'cell type, genotypeRNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
Adjusted p-valueLog2-fold change
6.9167 × 10-44-6.1
Kcnk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
3.4692 × 10-175.3
Kcnk3"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP negative"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
4.8003 × 10-9-5.1
Kcnk3'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.0531 × 10-20-5
Kcnk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
3.9069 × 10-101-4.9
Kcnk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.6866 × 10-79-4.9
Kcnk3'postnatal day 60' vs 'postnatal day 1' in 'insulin-expressing immature beta cell'cell type, developmental stageTranscription profiling by high throughput sequencing of murine beta cells at key stages of maturation
Adjusted p-valueLog2-fold change
8.2641 × 10-474.9
Kcnk3'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
3.9305 × 10-2-4.8
Kcnk3'Zbtb10 knockdown' vs 'control' at '6 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
6.9616 × 10-1594.7
Kcnk3'brown adipose tissue' vs 'white adipose tissue' in 'chow; 23 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
9.3861 × 10-99-4.7
Kcnk3'undifferentiated' vs 'differentiated; rosiglitazone' in '129S6sv/ev'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
9.9476 × 10-88-4.7
Kcnk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.129xB6'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.8722 × 10-184.5
Kcnk3"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP positive"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
1.8944 × 10-13-4.3
Kcnk3'synovial sarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
4.0085 × 10-7-4.3
Kcnk3'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
3.0561 × 10-7-4.2
Kcnk3'PTEN null' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
5.5329 × 10-3-4.1
Kcnk3'cortical epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1-Ly51+ td-tomato+t vs 'medullary epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1+Ly51- td-tomato-'cell type, phenotypeThymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche.
Adjusted p-valueLog2-fold change
4.6094 × 10-64
Kcnk3'AZD7507; AZD5069 (at same dosage); 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
7.7291 × 10-6-3.8
Kcnk3'doxycycline; 200 nanogram per milliliter; neoplasm; 5 day' vs 'none; normal; 0 day'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
3.9541 × 10-13-3.3
Kcnk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'C57BL/6J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.4558 × 10-5-3.3
Kcnk3'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.0428 × 10-63.2
Kcnk3'hematopoietic stem cell and hematopoietic multipotent progenitor cell' vs 'common myeloid progenitor'cell typeTranscription profiling by high throughput sequencing between multipotent hematopoietic stem progenitor cells LS+K) and myeloid committed cells (LS−K) of the mouse bone marrow
Adjusted p-valueLog2-fold change
3.0641 × 10-4-3.1
Kcnk3'osteosarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.5624 × 10-23.1
Kcnk3'SMRT shRNA' vs 'none' in 'none' at '0 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
5.3598 × 10-33
Kcnk3'uterine-specific Tsc2-null' vs 'wild type' in 'intact'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
1.2999 × 10-8-2.8
Kcnk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'SWR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.0665 × 10-43-2.7
Kcnk3'high fat diet; 30 degree celsius' vs 'chow; 23 degree celsius' in 'brown adipose tissue'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
8.7146 × 10-4-2.7
Kcnk3'inh-alpha/Tag transgenic' vs 'wild type' in 'none'compound, genotypeNovel genes involved in the pathophysiology of gonadotropin-dependent adrenocortical tumorigenesis in mice.
Adjusted p-valueLog2-fold change
1.0511 × 10-2-2.7
Kcnk3'hepatocyte-derived proliferative ducts (hepPDs)' vs 'hepatocyte'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
1.1429 × 10-32.6
Kcnk3'cetrorelix; 3 milligram per kilogram' vs 'none' in 'inh-alpha/Tag transgenic'compound, genotypeNovel genes involved in the pathophysiology of gonadotropin-dependent adrenocortical tumorigenesis in mice.
Adjusted p-valueLog2-fold change
1.5631 × 10-2-2.6
Kcnk3'cardiotoxin; 10 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq comparison of fibro-adipogenic progenitors (FAPs) from wild type, mdx and cardiotoxin-injured mice
Adjusted p-valueLog2-fold change
1.651 × 10-22.6
Kcnk3'uterine-specific Tsc2-null' vs 'wild type' in '17beta-estradiol'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
5.3839 × 10-5-2.5
Kcnk3'doxycycline; 200 nanogram per milliliter; neoplasm; 12 day' vs 'none; normal; 0 day'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
4.1658 × 10-42.5
Kcnk3'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
4.564 × 10-2-2.4
Kcnk3'status epilepticus' vs 'none' in 'astrocyte; soticlestat; 30 milligram per kilogram'cell type, compound, diseaseRNA-seq profiling of three distinct cell populations in a murine model of epilepsia with and without drug treatment
Adjusted p-valueLog2-fold change
1.2914 × 10-8-2.3
Kcnk3'Influenza A virus' vs 'none'infectRNA-seq of mouse alveolar macrophages from control and Influenza A virus infected animals
Adjusted p-valueLog2-fold change
5.066 × 10-72.3
Kcnk3'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
5.8796 × 10-6-2.3
Kcnk3'etoposide; 2.5 micromolar' vs 'none' in 'H2afj-∆7-KO'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
4.6552 × 10-92.2
Kcnk3'7 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
9.5081 × 10-5-2.1
Kcnk3'etoposide; 2.5 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
1.6906 × 10-3-2.1
Kcnk3'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
3.3305 × 10-242
Kcnk3'neurogenin-3-expressing endocrine progenitor cell' vs 'neurogenin-3-lacking pancreatic progenitor cell' at 'embryonic day 15.5'cell type, developmental stageTranscription profiling by high throughput sequencing of murine beta cells at key stages of maturation
Adjusted p-valueLog2-fold change
1.4078 × 10-5-2
Kcnk3'transgenic C3(1)-SV40Tag; 20 week' vs 'wild type; 8 week'age, genotypePrevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA
Adjusted p-valueLog2-fold change
4.7113 × 10-16-1.9
Kcnk3'Triple knockout (Zfp36-/-, TNFR1-/-, TNFR2-/-)' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of douple (TNFR1-/-/TNFR2-/-) and triple (Zfp36-/-/TNFR1-/-/TNFR2-/-) knockout mouse spleens
Adjusted p-valueLog2-fold change
2.0996 × 10-12-1.9
Kcnk3'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'endothelial cell; expressing AKT1'cell type, growth condition, phenotypeTranscription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture
Adjusted p-valueLog2-fold change
2.3145 × 10-7-1.9
Kcnk3'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 2 day' vs 'mock' in 'NOD/ShiLtJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
6.7903 × 10-3-1.9
Kcnk3'dorsolateral nucleus motor neuron' vs 'lumbar motor neurons'cell typeComparison of gene expression in motor pools with differential vulnerability in ALS
Adjusted p-valueLog2-fold change
6.4336 × 10-5-1.8
Kcnk3'carotid body' vs 'adrenal medulla'organism partExpression profile of mouse carotid body and adrenal medulla [RNA-Seq]
Adjusted p-valueLog2-fold change
8.8114 × 10-5-1.8
Kcnk3'smoke; 3000 microgram' vs 'control; 0 microgram' in 'wild type' at 'after 5 month exposure and 1 day post-exposure'compound, genotype, sampling time pointTranscription profiling by array of Nrf2 knockout mice exposed to cigarette smoke
Adjusted p-valueLog2-fold change
1.1671 × 10-4-1.8
Kcnk3'Crx knockout' vs 'control' at '20 zeitgeber'genotype, timeTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
Adjusted p-valueLog2-fold change
6.78 × 10-41.8
Kcnk3'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.2376 × 10-21.8
Kcnk3'PS2APP transgenic' vs 'non transgenic' in 'microglia cell' at '13 month'age, cell type, genotypeTranscription profiling by high throughput sequencing of astrocytes, microglial and neuronal cells from an Alzheimer's mouse model
Adjusted p-valueLog2-fold change
1.5853 × 10-2-1.8
Kcnk3'lung carcinoma' vs 'normal' in 'Epcam+CD11b-CD11c- epithelial cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
1.1964 × 10-61.7
Kcnk3'Reverbα-/- global knockout' vs 'Reverbα wild type' in 'not applicable; 13 week'age, diet, genotypeTissue-autonomous regulation of adipose expansion by core clock protein REVERBα
Adjusted p-valueLog2-fold change
3.7883 × 10-6-1.7
Kcnk3'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'brown adipose tissue'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues
Adjusted p-valueLog2-fold change
9.5097 × 10-4-1.7
Kcnk3'mPIN (mouse prostatic intraepithelial neoplasia)' vs 'normal'diseaseTranscription profiling by array of ventral prostates of wild type and p110 beta transgenic mice to investigate prostate cancer
Adjusted p-valueLog2-fold change
1.3956 × 10-31.7
Kcnk3'AZD7507; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
3.9868 × 10-2-1.7
Kcnk3'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
6.8447 × 10-51.6
Kcnk3'rosiglitazone; 100 nanomolar' vs 'none' in 'wild type genotype'compound, genotypeTranscriptional response to Rosiglitazone in adipocyte progenitors isolated from WT and Cited4-KO scWAT
Adjusted p-valueLog2-fold change
9.0163 × 10-3-1.6
Kcnk3'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'inguinal fat pad'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues
Adjusted p-valueLog2-fold change
2.2765 × 10-2-1.6
Kcnk3'wormy, worm left; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
2.8045 × 10-21.6
Kcnk3'reduced expression of miR-25' vs 'wild type'phenotypeTranscription profiling by high throughput sequencing of wild type and miR-25 agomir or antagomir treated mice
Adjusted p-valueLog2-fold change
5.5865 × 10-51.5
Kcnk3'rosiglitazone; 100 nanomolar' vs 'none' in 'Cited4-/-'compound, genotypeTranscriptional response to Rosiglitazone in adipocyte progenitors isolated from WT and Cited4-KO scWAT
Adjusted p-valueLog2-fold change
1.0838 × 10-41.5
Kcnk3'Dcrfx/fx;MisCre' vs 'wild type' in '5 day'age, genotypeTranscription profiling of testis from wild type mice and mice with a Sertoli-specific ablation of Dicer
Adjusted p-valueLog2-fold change
3.3268 × 10-4-1.5
Kcnk3'17beta-estradiol' vs 'DMSO' in 'wild type'compound, genotypeTranscription profiling of mouse male embryos treated with DMSO or 17beta-estradiol in wild type or ERalpha knock outs to assess the toxic effects of oestrogen exposure in fetal testis
Adjusted p-valueLog2-fold change
1.373 × 10-3-1.5
Kcnk3'SARS coronavirus MA15 E protein mutant Δ5' vs 'mock'infectHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Adjusted p-valueLog2-fold change
3.2292 × 10-31.5
Kcnk3'uterine-specific Tsc2-null' vs 'wild type' in 'oopherectomized'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
6.3801 × 10-3-1.5
Kcnk3'infarct and border region of left ventricle 5 days post-myocardial infarction; MRL/MpJ' vs 'left ventricle at baseline (no myocardial infarction) in the same region as the infarct in post-myocardial infarction hearts; MRL/MpJ'clinical information, strainExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Adjusted p-valueLog2-fold change
2.4183 × 10-2-1.5
Kcnk3'T-cell depleted bone marrow transplant' vs 'none' in 'normal'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
2.8362 × 10-211.4
Kcnk3'Abcc8-/-' vs 'wild type genotype' in 'normal; female'diet, genotype, sexEffects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome
Adjusted p-valueLog2-fold change
4.551 × 10-141.4
Kcnk3'Adrb1, Adrb2 and Adrb3 knockout' vs 'wild type genotype' in '15 degree celsius'genotype, temperatureRNA-seq of cold-induced transcriptome changes in subcutaneous adipose tissue of beta-adrenergic receptor knockout mice
Adjusted p-valueLog2-fold change
5.4313 × 10-6-1.4
Kcnk3'epithelium-specific Apc knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
1.0254 × 10-5-1.4
Kcnk3'30 days of tuberculosis' vs 'uninfected'disease, timeTranscription profiling by array of lungs from mice infected with tuberculosis
Adjusted p-valueLog2-fold change
2.133 × 10-5-1.4
Kcnk3'SARS coronavirus MA15; 2 day' vs 'mock' in 'CAST/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
6.8704 × 10-5-1.4
Kcnk3'Mycobacterium tuberculosis; DBA/2J congenic; 70 day' vs 'control; DBA/2J congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
9.7689 × 10-4-1.4
Kcnk3'Crx knockout' vs 'control' at '6 zeitgeber'genotype, timeTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
Adjusted p-valueLog2-fold change
2.9003 × 10-3-1.4
Kcnk3'19BL; differentiated 3factor-reprogrammed induced pluripotent stem cell' vs 'R1; differentiated embryonic stem cell' at '11 day'cell line, growth condition, timeNatural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines
Adjusted p-valueLog2-fold change
3.9028 × 10-3-1.4
Kcnk3'Sall4 -/-' vs 'wild type genotype'genotypeRNA-Seq of mouse embryonic stem cells in response to changes in Sall4
Adjusted p-valueLog2-fold change
6.538 × 10-3-1.4
Kcnk3'lung carcinoma' vs 'normal' in 'lung cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
5.8789 × 10-81.3
Kcnk3'6 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
3.3031 × 10-5-1.3
Kcnk3'heart-specific p53 and Mdm2 knockout; 7 day' vs 'heart-specific p53 and Mdm2 knockout; 1 day'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
1.0201 × 10-21.3
Kcnk3'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2; Il22-/-'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
1.0414 × 10-2-1.3
Kcnk3'Sall4 homozygous knockout' vs 'wild type genotype'genotypeRNA-Seq of Sall4 mutants in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
1.0536 × 10-21.3
Kcnk3'human chorionic gonadotropin; 5 International Unit' vs 'none' in 'bER knockout'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
1.5605 × 10-2-1.3
Kcnk3'SARS coronavirus MA15 lacking full-length E protein' vs 'mock'infectHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Adjusted p-valueLog2-fold change
3.6695 × 10-21.3
Kcnk3'ductus arteriosis' vs 'aorta'organism partGene Profiling in Mouse Fetal Ductus Arteriosus
Adjusted p-valueLog2-fold change
3.8948 × 10-21.3
Kcnk3'low-protein/high-carbohydrate diet' vs 'western diet'dietGene expression analysis of subcutaneous adipose tissue in mice fed with a low-protein/high carbohydrate diet
Adjusted p-valueLog2-fold change
1.6868 × 10-81.2
Kcnk3'Abcc8-/-' vs 'wild type genotype' in 'normal; male'diet, genotype, sexEffects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome
Adjusted p-valueLog2-fold change
4.753 × 10-71.2
Kcnk3'Abcc8-/-' vs 'wild type genotype' in 'high fat; male'diet, genotype, sexEffects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome
Adjusted p-valueLog2-fold change
1.0783 × 10-5-1.2
Kcnk3'Mycobacterium tuberculosis; C57BL/6J; 70 day' vs 'control; C57BL/6J; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
2.1575 × 10-5-1.2
Kcnk3'3110043O21Rik knockout; spleen' vs 'wild type genotype; spleen'genotype, organism part, sampling siteRNAseq of coding RNA in the liver, spleen, kidney, abdominal muscle and gonadal adipose tissue of knock out mice and wild type controls.
Adjusted p-valueLog2-fold change
4.1803 × 10-51.2
Kcnk3'10 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
4.8105 × 10-5-1.2
Kcnk3'70 days of tuberculosis' vs 'uninfected'disease, timeTranscription profiling by array of lungs from mice infected with tuberculosis
Adjusted p-valueLog2-fold change
1.9699 × 10-3-1.2
Kcnk3'infarct and border region of left ventricle 5 days post-myocardial infarction; C57BL/6J' vs 'left ventricle at baseline (no myocardial infarction) in the same region as the infarct in post-myocardial infarction hearts; C57BL/6J'clinical information, strainExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Adjusted p-valueLog2-fold change
2.7949 × 10-3-1.2
Kcnk3'SARS coronavirus MA15; 10^4 PFU' vs 'none' at '2 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
1.2627 × 10-2-1.2
Kcnk3'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.1489 × 10-21.2
Kcnk3'bER knockout' vs 'wild type' in 'human chorionic gonadotropin; 5 International Unit'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
2.783 × 10-2-1.2
Kcnk3'Trichuris muris' vs 'control' in 'mesenteric lymph node'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
2.9413 × 10-21.2
Kcnk3'co-culture' vs 'separate' in 'wild type genotype'genotype, growth conditionRNA-seq of wild-type and transformed Ink4a/Arf-/-; EGFRvIII neural stem cells in separate or co-culture conditions
Adjusted p-valueLog2-fold change
1.2634 × 10-9-1.1
Kcnk3'human-Mfn2 T111A/S442A-overexpressing (Mfn2AA)' vs 'tet-off control' in '5 week; left ventricle'age, genotype, organism partTranscription profiling by high throughput sequencing of a mitofusin 2 (Mfn2) mutant in mouse
Adjusted p-valueLog2-fold change
2.1937 × 10-71.1
Kcnk3'15 degree celsius' vs '20 to 22 degree celsius' in 'Adrb1, Adrb2 and Adrb3 knockout'genotype, temperatureRNA-seq of cold-induced transcriptome changes in subcutaneous adipose tissue of beta-adrenergic receptor knockout mice
Adjusted p-valueLog2-fold change
4.4712 × 10-6-1.1
Kcnk3'Mycobacterium tuberculosis; C57BL/6J; 30 day' vs 'control; C57BL/6J; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
4.5167 × 10-41.1
Kcnk3'4-hydroxytamoxifen-mediated deletion of Prmt5' vs 'wild type' in 'mouse neural progenitor cell'cell type, phenotypeTranscription profiling by high throughput sequencing of murine neural stem/progenitor cells lacking PRMT5 over control
Adjusted p-valueLog2-fold change
2.9747 × 10-3-1.1
Kcnk3'oculomotor nucleus motor neurons' vs 'lumbar motor neurons'cell typeComparison of gene expression in motor pools with differential vulnerability in ALS
Adjusted p-valueLog2-fold change
7.1921 × 10-3-1.1
Kcnk3'infarct and border region of left ventricle 1 day post-myocardial infarction; C57BL/6J' vs 'left ventricle at baseline (no myocardial infarction) in the same region as the infarct in post-myocardial infarction hearts; C57BL/6J'clinical information, strainExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Adjusted p-valueLog2-fold change
1.1978 × 10-2-1.1
Kcnk3'ulcer' vs 'distant normal tissue' in 'Bmp4 overexpression'genotype, sampling site, timeIntestinal ulcers from biopsy-wounded wild-type and Bmp4-overexpressing mice
Adjusted p-valueLog2-fold change
1.5104 × 10-2-1.1
Kcnk3'lipid nanoparticle complexed with ribonucleic acid expressing respiratory synctial virus F protein' vs 'phosphate buffered saline'stimulusMicroarray analysis of mouse whole genome using self-amplifying messenger (SAM) RNA delivered with different formulations compared to controls
Adjusted p-valueLog2-fold change
1.8703 × 10-2-1.1
Kcnk3'lipid nanoparticle alone' vs 'phosphate buffered saline'stimulusMicroarray analysis of mouse whole genome using self-amplifying messenger (SAM) RNA delivered with different formulations compared to controls
Adjusted p-valueLog2-fold change
3.5739 × 10-2-1.1
Kcnk3'Stat5a (Stat5abnull/Stat5b-)' vs 'wild type' at 'pregnancy'genotype, sampling time pointTranscription profiling by high throughput sequencing of mouse wild type and Stat5-mutant mammary tissues at parturition and early pregnancy
Adjusted p-valueLog2-fold change
1.1534 × 10-61
Kcnk3'brown adipose tissue' vs 'white adipose tissue' in 'high fat diet; 30 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
2.7401 × 10-6-1
Kcnk3'Influenza A virus' vs 'mock' in 'interleukin-22'infect, stimulusTranscription profiling by array of pulmonary gene expression in response to interleukin-22 during severe influenza
Adjusted p-valueLog2-fold change
5.5189 × 10-6-1
Kcnk3'spontaneous lung tumor' vs 'normal'disease state, diseaseTranscription profiling by array of spontaneous lung tumors in mice to compare to human non-small cell lung cancer
Adjusted p-valueLog2-fold change
1.077 × 10-51
Kcnk3'Abcc8 knockout' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of pancreatic beta cells from wild type and Abcc8 knockout mice
Adjusted p-valueLog2-fold change
6.2567 × 10-5-1
Kcnk3'Mycobacterium tuberculosis; DBA/2J congenic; 30 day' vs 'control; DBA/2J congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
1.1723 × 10-41
Kcnk3'heart-specific p53 knockout; 7 day' vs 'wild type phenotype'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
1.216 × 10-4-1
Kcnk3'Mycobacterium tuberculosis; D2.B6-Chr19 congenic; 70 day' vs 'control; D2.B6-Chr19 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
1.9431 × 10-4-1
Kcnk3'heart-specific Mdm2 knockout; 14 day' vs 'heart-specific Mdm2 knockout; 7 day'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
2.8833 × 10-4-1
Kcnk3'Mycobacterium tuberculosis; D2.B6-Chr7 congenic; 70 day' vs 'control; D2.B6-Chr7 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
3.0516 × 10-3-1
Kcnk3'SARS coronavirus MA15; 2 day' vs 'mock' in 'PWK/PhJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
4.6999 × 10-31
Kcnk3'left ventricle' vs 'right ventricle' in 'embryonic day 9.5'developmental stage, organism partTranscriptional Atlas of Cardiogenesis Maps Congenital Heart Disease Interactome
Adjusted p-valueLog2-fold change
6.6304 × 10-3-1
Kcnk3'epithelium-specific mutant beta-catenin expression' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
8.9878 × 10-3-1
Kcnk3'SARS coronavirus MA15' vs 'mock'infectHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Adjusted p-valueLog2-fold change
1.0564 × 10-21
Kcnk3'AMPK double knockout; floxed AMPK alpha 1 and 2 with RIP-Cre' vs 'floxed AMPK without RIP-Cre; wild type'genotype, phenotypeTranscription profiling by high throughput sequencing of pancreatic islets from LKB1 and AMPK knockout mice
Adjusted p-valueLog2-fold change
1.7538 × 10-2-1
Kcnk3'SARS coronavirus MA15; 10^5 PFU' vs 'none' at '2 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
3.4617 × 10-2-1
Kcnk3'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 2 day' vs 'mock' in '129S1/SvImJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
3.9199 × 10-2-1
Kcnk3"tunicamycin; 2 microgram per milliliter" vs "DMSO" in "A/J"compound, strainTranscription profiling by high throughput sequencing of mouse embryonic fibroblasts treated with tunicamycin to study the transcriptional response to endoplasmic reticulum stress