ENSMUSG00000069237 (Fam8a1)

mus musculus

family with sequence similarity 8, member A1

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Mus musculus
Organism part
Showing 49 experiments:
Created with Highcharts 6.2.0adrenal glandcentral neural epitheliumepididymisintestinal mucosamedulla oblongatapituitary glandsubmandibular glandwhole bodyaxillary lymph nodebronchuscorpora quadrigeminadifferentiated myotubeforelimbhippocampal formationlateral prominence neural epitheliummandibular archnon-floor plate neural epitheliumolfactory pitright cardiac atriumspinal cordtonguevagina
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Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
4.6624 × 10-2-8.9
Fam8a1'CD81 positive' vs 'CD81 negative' in 'visceral abdominal adipose tissue'organism part, phenotypeRNA-seq comparison of CD81 positive and negative cells in subcutaneous and visceral white fat and brown fat tissues in mouse
Adjusted p-valueLog2-fold change
6.9776 × 10-53.8
Fam8a1'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
1.1232 × 10-15-2.3
Fam8a1'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
2.9997 × 10-2-2.1
Fam8a1'hippocampus' vs 'cerebellum'organism partExpression data from adult Shh-responding astroglia cells in mice
Adjusted p-valueLog2-fold change
2.7041 × 10-41-1.8
Fam8a1'Alb-Cre-ERT2 / Cnot1 flox/flox' vs 'Cnot1 flox/flox' in 'none'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
6.2331 × 10-81.7
Fam8a1'mutant MyoD expression' at '24 hour' vs 'wild type MyoD expression' at '0 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
2.4262 × 10-3-1.7
Fam8a1'Zfp521 knockdown by siRNA' vs 'wild type' at '1 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
1.4414 × 10-2-1.7
Fam8a1'Zfp521 knockdown by siRNA' vs 'wild type' at '3 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
2.2227 × 10-21.7
Fam8a1'unilateral ureteral obstruction' vs 'sham' in 'TIMP3 -/-'genotype, treatmentTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Adjusted p-valueLog2-fold change
5.5757 × 10-4-1.6
Fam8a1'normobaric hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to normobaric hypoxia in vivo.
Adjusted p-valueLog2-fold change
2.2149 × 10-9-1.5
Fam8a1'extracellular vesicle; non-stimulated culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
3.8049 × 10-41.4
Fam8a1'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
4.5007 × 10-41.4
Fam8a1'Pax7 driven ablation of miR-1/133a' vs 'wild type'phenotypeMetabolic maturation during muscle stem cell differentiation is achieved by miR-1/133a-mediated inhibition of the Dlk-Dio3 mega gene cluster.
Adjusted p-valueLog2-fold change
5.39 × 10-3-1.4
Fam8a1'colitis' at '8 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
2.5524 × 10-751.3
Fam8a1'doxorubicin; 17.5 milligram per kilogram body weight' vs 'vehicle' in 'scramble; podocyte'cell type, compound, genotypeTranscription profiling to identify the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin
Adjusted p-valueLog2-fold change
2.2917 × 10-17-1.3
Fam8a1'α-GalCer; 2 microgram' vs 'none' in 'Cd1d homozyous knockout'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
5.0529 × 10-81.3
Fam8a1'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
1.1057 × 10-5-1.3
Fam8a1'collagen sandwich' at '2 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.6434 × 10-31.3
Fam8a1'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
5.2223 × 10-14-1.2
Fam8a1'epithelium-specific Apc knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
1.1668 × 10-81.2
Fam8a1'336 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine V6.5 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
1.1671 × 10-71.2
Fam8a1'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
2.4147 × 10-71.2
Fam8a1'6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
2.326 × 10-5-1.2
Fam8a1'PGC-1 beta knock in' vs 'wild type'genotypeTranscription profiling by array of skeletal muscle from PGC-1 beta transgenic mice
Adjusted p-valueLog2-fold change
1.3712 × 10-3-1.2
Fam8a1'collagen sandwich' at '3 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.0675 × 10-541.1
Fam8a1'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
3.6362 × 10-24-1.1
Fam8a1'liver-specific Cnot3 knockout' vs 'wild type'phenotypeRoles of mRNA decay in liver development
Adjusted p-valueLog2-fold change
1.1173 × 10-14-1.1
Fam8a1'epithelium-specific mutant beta-catenin expression' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
5.9718 × 10-7-1.1
Fam8a1'Chikungunya virus; late stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
1.292 × 10-61.1
Fam8a1'168 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine V6.5 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
1.682 × 10-51.1
Fam8a1'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; MEF2A knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.6722 × 10-4-1.1
Fam8a1'AZD5069; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
2.7336 × 10-2-1.1
Fam8a1'Tetrafluororethane; 50000 part per million; air' vs 'none; ; air'compound, treatmentTranscription profiling by array of Mus musculus liver tissue after exposure to various carcinogenic chemicals
Adjusted p-valueLog2-fold change
3.0464 × 10-231
Fam8a1'CD4-positive T cell' vs 'CD8-positive T cell' in 'Egr2-GFP knockin; Egr2-GFP high'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
2.5052 × 10-8-1
Fam8a1'hepatocyte-derived proliferative ducts (hepPDs)' vs 'hepatocyte'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
1.4374 × 10-7-1
Fam8a1'hyperthermia' vs 'control'treatmentTranscription profiling of mouse Jardine SIDS Model
Adjusted p-valueLog2-fold change
1.3129 × 10-61
Fam8a1'10 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
3.0686 × 10-61
Fam8a1'TUT4 deficiency; TUT7 knockout' vs 'wild type'phenotypeMicroarray profiling of mouse pachytene cells deficient for UPF2 or both TUT4 and TUT7
Adjusted p-valueLog2-fold change
3.5036 × 10-41
Fam8a1'alpha-amanitin; maternal Ring1-Rnf+' vs 'none; maternal Ring1-Rnf+'compound, genotypePolycomb function during oogenesis is required for mouse early embryonic development (2-cell embryos)
Adjusted p-valueLog2-fold change
3.8069 × 10-4-1
Fam8a1'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
9.6023 × 10-41
Fam8a1'erythroblast' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
1.4208 × 10-31
Fam8a1'chemical hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to chemical hypoxia in vivo.
Adjusted p-valueLog2-fold change
1.542 × 10-3-1
Fam8a1"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP positive"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
4.1863 × 10-21
Fam8a1'Fhl1 knockdown by siRNA' vs 'wild type' at '1 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
4.684 × 10-21
Fam8a1'Mxd1 knockdown by siRNA' vs 'wild type' at '1 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Synonym
C78339
Ortholog
ENSTNIG00000017780 (Bos taurus), Fam8a1 (Rattus norvegicus), fam8a1b (Danio rerio), fam8a1 (Xenopus tropicalis), ENSPANG00000016968 (Papio anubis), ENSOCUG00000002970 (Oryctolagus cuniculus), fam8a1b (Tetraodon nigroviridis), ENSCING00000011363 (Ciona intestinalis), FAM8A1 (Pan troglodytes), FAM8A1 (Dasypus novemcinctus), FAM8A1 (Chlorocebus sabaeus), F48B9.8 (Caenorhabditis elegans), CG8237 (Drosophila melanogaster), FAM8A1 (Gorilla gorilla), FAM8A1 (Anolis carolinensis), FAM8A1 (Pongo abelii), FAM8A1 (Monodelphis domestica), FAM8A1 (Bos taurus), ENSCSAVG00000002521 (Ciona savignyi), FAM8A1 (Ornithorhynchus anatinus), FAM8A1 (Sus scrofa), fam8a1a (Danio rerio), FAM8A1 (Homo sapiens), FAM8A1 (Macaca mulatta), FAM8A1 (Anas platyrhynchos), ENSOARG00020021308 (Ciona savignyi), FAM8A1 (Gallus gallus)
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
A_55_P1982420, 4879438, ILMN_3162465, 4643326, 4629029, aa271327_s_at, 133906_at, 4758974, 5390470, 5181737, 17287024, 4458016, 5404524, 10404928, 4950645, A_51_P155550, 5337747, 1433475_a_at, 5008603, 1433476_at, 4401342, 5036972, ILMN_1246895, 5459545, 97897_at, 5437994