ENSMUSG00000079180 (Mptx2)

mus musculus

mucosal pentraxin 2

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Mus musculus
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Sun et al., 2020 - Organism part
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Proteomics
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Transcriptomics
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-6.5
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2.6
Display log2-fold change
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
6.9707 × 10-12-6.5
Mptx2"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP positive"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
1.3038 × 10-5-3.6
Mptx2"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP negative"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
6.2808 × 10-270-3.2
Mptx2'GSK-LSD1; 2 micromolar' vs 'none'compoundRNA-seq of small intestinal organoids treated with an inhibitor for the epigenetic modifier LSD1
Adjusted p-valueLog2-fold change
4.9909 × 10-22.6
Mptx2'tamoxifen induction at 2 months, wait 6 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
3.57 × 10-622
Mptx2'interleukin-13 (Mus musculus); 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
1.6574 × 10-3-1.9
Mptx2'anti-IL-22; 150 micrograms' vs 'none' in 'methotrexate; first dose 120 milligram per kilogram; second dose 60 milligram per kilogram; wild type phenotype' at '1 day'compound, phenotype, stimulus, timeRNA-seq of mouse crypts to investigate Rorc gamma t-deficient mice tissue repair compared to wild type controls
Adjusted p-valueLog2-fold change
1.7228 × 10-30-1.8
Mptx2'epithelium-specific Bcl9; Bcl9l knockout and mutant beta-catenin expression' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
6.7787 × 10-431.7
Mptx2'interferon gamma; 10 nanogram per milliliter and interleukin-22; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
4.3168 × 10-401.6
Mptx2'interleukin-22 (Mus Musculus); 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
2.2816 × 10-21.6
Mptx2'Nippostrongylus brasiliensis' vs 'none'infectRNAseq of small intestinal epithelium extracted from mice infected with Nippostrongylus brasiliensis
Adjusted p-valueLog2-fold change
3.8492 × 10-4-1.5
Mptx2'Rorc homozygous knockout' vs 'wild type phenotype' in 'methotrexate; first dose 120 milligram per kilogram; second dose 60 milligram per kilogram' at '1 day'compound, phenotype, stimulus, timeRNA-seq of mouse crypts to investigate Rorc gamma t-deficient mice tissue repair compared to wild type controls
Adjusted p-valueLog2-fold change
5.3258 × 10-41.5
Mptx2'2'-fucosyllactose supplementation' vs 'control' in '8 weeks post-ileocecal resection'diet, treatmentTranscriptomic characterization of the impact of 2'-fucosyllactose supplementation on intestinal adaptation following ileocecal resection.
Adjusted p-valueLog2-fold change
5.3364 × 10-3-1.4
Mptx2'CKIαΔgut/p53R172H' vs 'CKIαΔgut/p53Δgut' in 'ileum'compound, genotype, organism partRNAseq of enterocytes of the jejunum and Ileum from transgene C57BL/6 mice harboring a CKIαΔgut knock-out
Adjusted p-valueLog2-fold change
1.5202 × 10-21.4
Mptx2'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
2.5131 × 10-81.2
Mptx2'western diet' vs 'standard diet'dietRNA-seq of full thickness small intestine from wild type mice that were either exposed or not with western diet for 8 weeks
Adjusted p-valueLog2-fold change
3.9877 × 10-171
Mptx2'interferon gamma; 10 nanogram per milliliter and interleukin-13; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
1.8593 × 10-2-1
Mptx2'epithelium-specific Apc; Bcl9; Bcl9l knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin