ENSMUSG00000101972 (H3c11)

mus musculus

H3 clustered histone 11

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Mus musculus
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Showing 28 experiments:
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Created with Highcharts 6.2.0adrenal glandcaecumcorpora quadrigeminaepididymis and seminiferous tubuleheartlateral prominence neural epitheliummedial prefrontal cortexolfactory epitheliumprostate glandstomachurinary bladderzone of skinbone (os femoris)cerebellumdorsal control neural epitheliumforelimbintestinemandibular archmuscle (biceps femoris)pancreassmall intestinethymusvesicular gland
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GENCODE
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14 - embryonic day 10.5
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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9 in 3 strains - C57BL/6
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Mammalian Kaessmann
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49 FANTOM5 project - adult
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14 - embryonic day 9.5
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14 - embryonic day 8.5
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9
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49 FANTOM5 project - neonate
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Mernberger et al 2019 - Organism Part
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Vertebrates
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6
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 12
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3 Soumillon et al
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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2
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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Proteomics
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Transcriptomics
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Display log2-fold change
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
5.1772 × 10-16-7.1
H3c11'AZD5069; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
2.8908 × 10-12-7
H3c11'AZD7507; AZD5069 (at same dosage); 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
5.3412 × 10-64
H3c11'PTEN null, P53-/-' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
1.1234 × 10-43.9
H3c11'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
3.4914 × 10-53.7
H3c11'lipopolysaccharide; 10 nanogram per milliliter and SGC-CBP30; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.4231 × 10-33.7
H3c11'Salmonella enterica serovar Typhimurium' vs 'control' in 'bone marrow macrophage from 129P2 mouse strain'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
5.0778 × 10-43.3
H3c11'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'HdhQ111 knock-in'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
6.6702 × 10-43.3
H3c11'lipopolysaccharide; 10 nanogram per milliliter and PFI-1; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.2437 × 10-33.3
H3c11'actinomycin D; 8 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
1.5837 × 10-3-3.3
H3c11'Irx3 knockout' vs 'control' at '7 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
3.5355 × 10-33
H3c11'extracellular vesicle; non-stimulated culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
7.2014 × 10-33
H3c11'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.8455 × 10-23
H3c11'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.5366 × 10-42.9
H3c11'Crx knockout' vs 'control' at '6 zeitgeber'genotype, timeTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
Adjusted p-valueLog2-fold change
1.597 × 10-42.9
H3c11'Crx knockout' vs 'control' at '20 zeitgeber'genotype, timeTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
Adjusted p-valueLog2-fold change
5.4522 × 10-42.8
H3c11'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'wild type'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
4.3601 × 10-22.7
H3c11'interferon gamma; 10 nanogram per milliliter and interleukin-22; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
5.6856 × 10-6-2.6
H3c11'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.3397 × 10-42.6
H3c11'chemical hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to chemical hypoxia in vivo.
Adjusted p-valueLog2-fold change
1.4599 × 10-3-2.6
H3c11'Yersinia pestis' vs 'control' in 'neutrophil'cell type, infect, sampling siteSpatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague
Adjusted p-valueLog2-fold change
1.5426 × 10-22.6
H3c11'PTEN null' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
4.6613 × 10-52.5
H3c11'cycloheximide and 100 unit per milliliter interferon alpha' vs 'DMSO'compoundDissecting primary (translation independent) from secondary (translation dependent) IFN-mediated differential gene expression
Adjusted p-valueLog2-fold change
2.9268 × 10-2-2.5
H3c11'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
1.2451 × 10-62.4
H3c11'cycloheximide and 100 unit per milliliter interferon gamma' vs 'DMSO'compoundDissecting primary (translation independent) from secondary (translation dependent) IFN-mediated differential gene expression
Adjusted p-valueLog2-fold change
1.2743 × 10-42.4
H3c11'cycloheximide' vs 'DMSO'compoundDissecting primary (translation independent) from secondary (translation dependent) IFN-mediated differential gene expression
Adjusted p-valueLog2-fold change
1.2406 × 10-32.4
H3c11'Taf10-/-' vs 'wild type'genotypeTranscription profiling by array of liver from Taf10 knock out mice
Adjusted p-valueLog2-fold change
1.5038 × 10-22.4
H3c11'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
7.1544 × 10-52.3
H3c11'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 cell line'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
3.389 × 10-72.2
H3c11'Influenza A virus' vs 'mock' in 'IgG1'infect, stimulusTranscription profiling by array of pulmonary gene expression in response to interleukin-22 during severe influenza
Adjusted p-valueLog2-fold change
2.257 × 10-72.1
H3c11'Influenza A virus' vs 'mock' in 'interleukin-22'infect, stimulusTranscription profiling by array of pulmonary gene expression in response to interleukin-22 during severe influenza
Adjusted p-valueLog2-fold change
2.7429 × 10-42.1
H3c11'Plasmodium chabaudi infection' vs 'no infection' in 'adjuvant only'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
1.1322 × 10-22.1
H3c11'extracellular vesicle; MET cell culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
1.5148 × 10-32
H3c11'Tumor Necrosis Factor' vs 'none'stimulusTranscription profiling by high throughput sequencing of CD8 single positive thymocytes from F5 Rag1KO TCR transgenic mice stimulated with tumor necrosis factor
Adjusted p-valueLog2-fold change
3.8135 × 10-3-2
H3c11'subventicular zone of the lateral ventricle' vs 'cerebellum'organism partExpression data from adult Shh-responding astroglia cells in mice
Adjusted p-valueLog2-fold change
5.1957 × 10-51.9
H3c11'db/db' vs 'wild type genotype' in 'control miRNA; re-fed'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
1.3944 × 10-41.9
H3c11'shRNA mediated Brd4 knockdown' vs 'control shRNA'treatmentExpression Data For BRD4 Inhibition
Adjusted p-valueLog2-fold change
1.1687 × 10-3-1.9
H3c11'fasted' vs 're-fed' in 'db/db; control miRNA'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
2.4942 × 10-21.9
H3c11'cut nerve; 7 day' vs 'none'injury, protocol, timeChanges in the coding/non-coding transcriptome and DNA methylome that define the Schwann cell repair phenotype after nerve injury
Adjusted p-valueLog2-fold change
5.1851 × 10-8-1.8
H3c11'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.0903 × 10-4-1.8
H3c11'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.2956 × 10-4-1.8
H3c11'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
5.6786 × 10-3-1.8
H3c11'hippocampus' vs 'cerebellum'organism partExpression data from adult Shh-responding astroglia cells in mice
Adjusted p-valueLog2-fold change
2.8326 × 10-6-1.6
H3c11'Staphylococcus aureus Sanger476; 2 hour' vs 'none; 0 hour' in 'C57BL/6J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
8.536 × 10-31.6
H3c11'high fat diet; 30 degree celsius' vs 'chow; 23 degree celsius' in 'brown adipose tissue'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
4.1813 × 10-21.6
H3c11'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
5.1851 × 10-5-1.5
H3c11'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.3257 × 10-31.5
H3c11'hypobaric hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to hypobaric hypoxia at Mt. Everest in vivo.
Adjusted p-valueLog2-fold change
1.0833 × 10-21.5
H3c11'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
5.8661 × 10-61.4
H3c11'5-aza-2'-deoxycytidine; 5 micromolar' vs 'none'compoundTranscription profiling by array of mouse primary dermal fibroblasts after treatment with 5-aza-2'-deoxycytidine
Adjusted p-valueLog2-fold change
1.3061 × 10-31.4
H3c11'L-Pex5 knock-out' vs 'wild type'genotypeTranscription profiling by array of liver from L-Pex5 knock-out mice
Adjusted p-valueLog2-fold change
1.4301 × 10-3-1.4
H3c11'fasted' vs 're-fed' in 'db/db; Gabpa miRNA'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
1.4861 × 10-31.4
H3c11'37 degree celsius' vs '31.5 degree celsius'temperatureTranscription profiling by array of mouse oligodendrocyte precursor cells cultured at 31.5 degC and 37 degC
Adjusted p-valueLog2-fold change
2.4231 × 10-31.4
H3c11'brown adipose tissue' vs 'white adipose tissue' in 'high fat diet; 30 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
4.0226 × 10-21.4
H3c11'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
8.644 × 10-41.3
H3c11'Plasmodium chabaudi infection' vs 'no infection' in 'vaccination'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
1.3999 × 10-3-1.3
H3c11'synovial sarcoma' vs 'normal'diseaseTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
Adjusted p-valueLog2-fold change
3.3701 × 10-5-1.2
H3c11'Plasmodium berghei' vs 'none' in 'none'compound, infectTranscription profiling by array of mouse blood infected with Plasmodium berghei after treatment with activated charcoal
Adjusted p-valueLog2-fold change
1.7808 × 10-3-1.2
H3c11'Staphylococcus aureus Sanger476; 2 hour' vs 'none; 0 hour' in 'BALB/cByJ'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
5.2869 × 10-51.1
H3c11Synacthen vs sodium chloride controlcompoundTranscription controls growth, cell kinetics and cholesterol supply to sustain ACTH responses.
Adjusted p-valueLog2-fold change
3.9614 × 10-4-1.1
H3c11'NOD' vs 'C57BL/6' in 'steady state' at '0 hour'strain, time, treatmentExpression data from NOD and C57BL/6 mouse pancreas CD8α- Dendritic Cells (DCs) under steady-state and after in-vitro LPS stimulation
Adjusted p-valueLog2-fold change
1.8654 × 10-2-1.1
H3c11'expanded on HUVEC and m5GF in the presence of mD1R for 7 days' vs 'control'treatmentExpression data from cultured c-Kit+Sca-1+Lin- (KSL)cells
Adjusted p-valueLog2-fold change
1.8785 × 10-3-1
H3c11'transgenic C3(1)-SV40Tag; 20 week' vs 'wild type; 8 week'age, genotypePrevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA
Adjusted p-valueLog2-fold change
3.9856 × 10-31
H3c11'diphtheria toxin; 30 nanogram per gram' vs 'none'stimulusRNA-seq of mouse brain tissue repopulating microglia in response to traumatic brain injury