ENSRNOG00000006069 (Eif2ak3)

rattus norvegicus

eukaryotic translation initiation factor 2 alpha kinase 3

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Rattus norvegicus
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Showing 12 experiments:
Created with Highcharts 6.2.0adrenal glandbraincalcaneal tendoncolonforepaw flexor tendongastrocnemiusheartkidneyliverlungpatellar tendonskeletal muscle tissuespleensupraspinatus tendontestisthymusuterus
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11 Yu - male, juvenile
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11 Yu - male, elderly
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11 Yu - male, adult
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11 Yu - male, adolescent
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11 Yu - female, juvenile
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11 Yu - female, elderly
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11 Yu - female, adult
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11 Yu - female, adolescent
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9 Merkin - Sprague-Dawley
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9 Merkin - F344/Cr1
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9 Merkin - BN/SsNHsd
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Organism parts - tendons - Mendias et al
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Proteomics
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Transcriptomics
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-1.9
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Display log2-fold change
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
3.4111 × 10-2-1.9
Eif2ak3'forskolin; 10 micromolar; 2 hour' vs 'none; 0 hour'compound, timeTranscription profiling by array of rat PC12 cells treated with cholecystokinin (CCK-8S) for 2, 4, 8, and 16 hours
Adjusted p-valueLog2-fold change
2.2608 × 10-41.4
Eif2ak3'ethinylestradiol; 10 milligram per kilogram' vs 'none' in 'ethinylestradiol; kidney' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
2.2071 × 10-31.4
Eif2ak3'colchicine; 15 milligram per kilogram' vs 'none' in 'colchicine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
3.7394 × 10-41.3
Eif2ak3'ethinylestradiol; 10 milligram per kilogram' vs 'none' in 'ethinylestradiol; kidney' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
4.7071 × 10-6-1.1
Eif2ak3'collagen sandwich' at '8 day' vs 'monolayer culture' at '8 day'growth condition, timeGenome-wide gene expression profiles of primary hepatocytes in two different culture systems over an 8-day period
Adjusted p-valueLog2-fold change
3.9712 × 10-41.1
Eif2ak3'ethinylestradiol; 3 milligram per kilogram' vs 'none' in 'ethinylestradiol; kidney' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
1.6113 × 10-31.1
Eif2ak3'ethinylestradiol; 10 milligram per kilogram' vs 'none' in 'ethinylestradiol; kidney' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
2.206 × 10-21.1
Eif2ak3'50 milligram per kilogram; methylprednisolone' at '4 hour' vs 'none' at '0 hour' on 'Affymetrix RG_U34A Array'compound, timeTranscription profiling by array of rat liver after treatment with methylprednisolone
Adjusted p-valueLog2-fold change
3.3011 × 10-21.1
Eif2ak3'1-napthylisothiocyanate; bile duct' at '6 hour' vs 'vehicle; bile duct' at '6 hour'compound, organism part, timeGene expression in hepatocytes and bile ducts from ANIT-treated rats
Adjusted p-valueLog2-fold change
9.7639 × 10-7-1
Eif2ak3'adult' vs 'neonate'developmental stageTranscription profiling by array of neonatal and adult rat ventricular cardiomyocytes
Adjusted p-valueLog2-fold change
4.7089 × 10-5-1
Eif2ak3'whey diet' vs 'casein control diet'dietTranscription profiling by array of rat colon after soy or wheat diet
Adjusted p-valueLog2-fold change
5.6291 × 10-41
Eif2ak3'monocrotaline; 30 milligram per kilogram' vs 'none' in 'monocrotaline; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
8.6533 × 10-41
Eif2ak3'cyclosporine A; 300 milligram per kilogram' vs 'none' in 'cyclosporine A; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.662 × 10-31
Eif2ak3'ethinylestradiol; 3 milligram per kilogram' vs 'none' in 'ethinylestradiol; kidney' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
1.9909 × 10-31
Eif2ak3'monocrotaline; 10 milligram per kilogram' vs 'none' in 'monocrotaline; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
2.4254 × 10-3-1
Eif2ak3'bisphenol A; 10^-9 molar' at '7 day' vs 'control; 10^-9 molar' at '7 day'compound, timeAssessment of low-dose bisphenol A (BPA) toxicity in rat thyroid follicular cells by gene expression microarray
Adjusted p-valueLog2-fold change
4.1857 × 10-31
Eif2ak3'ethionamide; 300 milligram per kilogram' vs 'none' in 'ethionamide; liver' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.