ENSRNOG00000008676 (Emp1)

rattus norvegicus

epithelial membrane protein 1

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Rattus norvegicus
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Showing 12 experiments:
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Created with Highcharts 6.2.0adrenal glandbraincalcaneal tendoncolonforepaw flexor tendongastrocnemiusheartkidneyliverlungpatellar tendonskeletal muscle tissuespleensupraspinatus tendontestisthymusuterus
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11 Yu - male, juvenile
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11 Yu - male, elderly
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11 Yu - male, adult
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11 Yu - male, adolescent
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11 Yu - female, juvenile
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11 Yu - female, elderly
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11 Yu - female, adult
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11 Yu - female, adolescent
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9 Merkin - Sprague-Dawley
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9 Merkin - F344/Cr1
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9 Merkin - BN/SsNHsd
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Organism parts - tendons - Mendias et al
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Proteomics
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Transcriptomics
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-2.6
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3.3
Display log2-fold change
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
7.2265 × 10-43.3
Emp1'1-napthylisothiocyanate; bile duct' at '6 hour' vs 'vehicle; bile duct' at '6 hour'compound, organism part, timeGene expression in hepatocytes and bile ducts from ANIT-treated rats
Adjusted p-valueLog2-fold change
3.0411 × 10-372.6
Emp1'2 weeks after L5 spinal nerve ligation' vs 'control'growth condition, timeRNA-seq of rat dorsal root ganglia after ligation to investigate central nervous system transcriptomics in chronic pain using agnostic splice site discovery methods
Adjusted p-valueLog2-fold change
3.1607 × 10-12-2.6
Emp1'cyclophosphamide; 150 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.9195 × 10-7-2.6
Emp1'indomethacin; 50 milligram per kilogram' vs 'none' in 'indomethacin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
3.0569 × 10-72.5
Emp1'48 hour' vs '0 hour' in 'hepatocyte'cell type, timeAssessing concordance of drug-induced transcriptional response in rodent liver and cultured hepatocytes
Adjusted p-valueLog2-fold change
5.4514 × 10-11-2.4
Emp1'ciprofloxacin; 300 milligram per kilogram' vs 'none' in 'ciprofloxacin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.7794 × 10-9-2.4
Emp1'indomethacin; 15 milligram per kilogram' vs 'none' in 'indomethacin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
4.4963 × 10-22.4
Emp1'cholecystokinin-8S; 200 nanomolar; 2 hour' vs 'none; 0 hour'compound, timeTranscription profiling by array of rat PC12 cells treated with cholecystokinin (CCK-8S) for 2, 4, 8, and 16 hours
Adjusted p-valueLog2-fold change
8.0866 × 10-14-2.3
Emp1'imipramine; 30 milligram per kilogram' vs 'none' in 'imipramine; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
1.5629 × 10-92.3
Emp1'imipramine; 30 milligram per kilogram' vs 'none' in 'imipramine; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
7.3198 × 10-62.3
Emp1'4 hour' vs '0 hour' in 'hepatocyte'cell type, timeAssessing concordance of drug-induced transcriptional response in rodent liver and cultured hepatocytes
Adjusted p-valueLog2-fold change
1.6735 × 10-152.2
Emp1'allopurinol; 15 milligram per kilogram' vs 'none' in 'allopurinol; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
8.9749 × 10-152.2
Emp1'captopril; 300 milligram per kilogram' vs 'none' in 'captopril; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
2.1748 × 10-132.2
Emp1'acetazolamide; 60 milligram per kilogram' vs 'none' in 'acetazolamide; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
1.8574 × 10-10-2.2
Emp1'erythromycin ethylsuccinate; 100 milligram per kilogram' vs 'none' in 'erythromycin ethylsuccinate; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
1.8564 × 10-9-2.2
Emp1'imipramine; 100 milligram per kilogram' vs 'none' in 'imipramine; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
1.0804 × 10-62.2
Emp1'bromoethylamine; 60 milligram per kilogram' vs 'none' in 'bromoethylamine; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
4.4172 × 10-12-2.1
Emp1'erythromycin ethylsuccinate; 1000 milligram per kilogram' vs 'none' in 'erythromycin ethylsuccinate; kidney' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
2.188 × 10-11-2.1
Emp1'omeprazole; 1000 milligram per kilogram' vs 'none' in 'omeprazole; kidney' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
1.2193 × 10-9-2.1
Emp1'ethionine; 80 milligram per kilogram' vs 'none' in 'ethionine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
8.2577 × 10-92.1
Emp1'carboplatin; 30 milligram per kilogram' vs 'none' in 'carboplatin; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
5.5221 × 10-82.1
Emp1'24 hour' vs '0 hour' in 'hepatocyte'cell type, timeAssessing concordance of drug-induced transcriptional response in rodent liver and cultured hepatocytes
Adjusted p-valueLog2-fold change
5.848 × 10-142
Emp1'captopril; 100 milligram per kilogram' vs 'none' in 'captopril; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
5.9512 × 10-14-2
Emp1'allopurinol; 15 milligram per kilogram' vs 'none' in 'allopurinol; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
1.6129 × 10-13-2
Emp1'cyclophosphamide; 50 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
5.0603 × 10-122
Emp1'omeprazole; 100 milligram per kilogram' vs 'none' in 'omeprazole; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
6.9104 × 10-92
Emp1'caffeine; 10 milligram per kilogram' vs 'none' in 'caffeine; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.278 × 10-8-2
Emp1'omeprazole; 100 milligram per kilogram' vs 'none' in 'omeprazole; kidney' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
8.6982 × 10-82
Emp1'bromoethylamine; 6 milligram per kilogram' vs 'none' in 'bromoethylamine; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
7.6671 × 10-19-1.9
Emp1'nitrofurantoin; 600 milligram per kilogram' vs 'none' in 'nitrofurantoin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
5.4836 × 10-161.9
Emp1'cyclophosphamide; 5 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.98 × 10-11-1.9
Emp1'puromycin aminonucleoside; 120 milligram per kilogram' vs 'none' in 'puromycin aminonucleoside; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
8.7628 × 10-101.9
Emp1'puromycin aminonucleoside; 120 milligram per kilogram' vs 'none' in 'puromycin aminonucleoside; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
2.8978 × 10-91.9
Emp1'cisplatin; 3 milligram per kilogram' vs 'none' in 'cisplatin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
2.2634 × 10-81.9
Emp1'cephalothin; 300 milligram per kilogram' vs 'none' in 'cephalothin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
4.1069 × 10-7-1.9
Emp1'allopurinol; 50 milligram per kilogram' vs 'none' in 'allopurinol; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
1.586 × 10-6-1.9
Emp1'whey diet' vs 'casein control diet'dietTranscription profiling by array of rat colon after soy or wheat diet
Adjusted p-valueLog2-fold change
1.7585 × 10-61.9
Emp1'caffeine; 100 milligram per kilogram' vs 'none' in 'caffeine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
9.4627 × 10-51.9
Emp1'puromycin aminonucleoside; 12 milligram per kilogram' vs 'none' in 'puromycin aminonucleoside; kidney' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
3.6177 × 10-11-1.8
Emp1'ketoconazole; 10 milligram per kilogram' vs 'none' in 'ketoconazole; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
2.6049 × 10-10-1.8
Emp1'cyclophosphamide; 150 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
3.1885 × 10-61.8
Emp1'cobalt chloride; 62 micromolar' vs 'none' in 'H4-II-E-C3'cell line, compoundExposure to Cobalt Causes Transcriptomic and Proteomic Changes in Two Rat Liver Derived Cell Lines
Adjusted p-valueLog2-fold change
2.6636 × 10-51.8
Emp1'acetazolamide; 60 milligram per kilogram' vs 'none' in 'acetazolamide; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
4.4775 × 10-5-1.8
Emp1'72 hour' vs '0 hour'timeTranscription profiling by array of Rattus norvegicus muscle samples in response to chronic dose of corticosteroids
Adjusted p-valueLog2-fold change
5.4731 × 10-5-1.8
Emp1'96 hour' vs '0 hour'timeTranscription profiling by array of Rattus norvegicus muscle samples in response to chronic dose of corticosteroids
Adjusted p-valueLog2-fold change
8.9497 × 10-51.8
Emp1'methapyrilene; 100 milligram per kilogram' vs 'none' in 'methapyrilene; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
1.8706 × 10-41.8
Emp1'thioacetamide; 45 milligram per kilogram' vs 'none' in 'thioacetamide; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
1.2342 × 10-3-1.8
Emp1'bromobenzene; 100 milligram per kilogram' vs 'none' in 'bromobenzene; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
1.9909 × 10-48-1.7
Emp1'24 hour culture at sarcomere length = 1.8 microns' vs 'control'stimulusRNA-Seq of rat myocardial slices cultured with biomimetic electromechanical stimulation
Adjusted p-valueLog2-fold change
2.594 × 10-101.7
Emp1'caffeine; 10 milligram per kilogram' vs 'none' in 'caffeine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
8.1409 × 10-91.7
Emp1'cyclosporine A; 300 milligram per kilogram' vs 'none' in 'cyclosporine A; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
2.492 × 10-61.7
Emp1'bromobenzene; 30 milligram per kilogram' vs 'none' in 'bromobenzene; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
1.2896 × 10-2-1.7
Emp1'monocrotaline; 30 milligram per kilogram' vs 'none' in 'monocrotaline; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
1.3062 × 10-21.7
Emp1'rifampicin; 60 milligram per kilogram' vs 'none' in 'rifampicin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
1.6171 × 10-81.6
Emp1'nitrofurantoin; 10 milligram per kilogram' vs 'none' in 'nitrofurantoin; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
1.3723 × 10-6-1.6
Emp1'acetazolamide; 60 milligram per kilogram' vs 'none' in 'acetazolamide; kidney' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
4.4284 × 10-41.6
Emp1'monocrotaline; 30 milligram per kilogram' vs 'none' in 'monocrotaline; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
2.961 × 10-3-1.6
Emp1'doxorubicin; 10 milligram per kilogram' vs 'none' in 'doxorubicin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
7.4739 × 10-31.6
Emp1'neuromuscular junction' vs 'non-neuromuscular junction' in 'tibialis anterior'organism part, sampling siteTranscription profiling by array of fiber and neuromuscular junctions in Rattus norvegicus extraocular and tibialis anterior muscles
Adjusted p-valueLog2-fold change
9.7428 × 10-31.6
Emp1'distal middle cerebral artery occlusion surgery; AAV7-hMANF infusion' vs 'sham; none'injury, treatmentRNA-seq of peri-infarct cortex of the rat dMCAO model of ischemic stroke treated with AAV7-hMANF or AAV7-GFP
Adjusted p-valueLog2-fold change
1.715 × 10-21.6
Emp1'neuromuscular junction' vs 'non-neuromuscular junction' in 'rectus extraocular muscle'organism part, sampling siteTranscription profiling by array of fiber and neuromuscular junctions in Rattus norvegicus extraocular and tibialis anterior muscles
Adjusted p-valueLog2-fold change
2.5473 × 10-21.6
Emp1'acetamidofluorene; 30 milligram per kilogram' vs 'none' in 'acetamidofluorene; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with A.
Adjusted p-valueLog2-fold change
7.4281 × 10-47-1.5
Emp1'24 hour culture at sarcomere length = 2.2 microns' vs 'control'stimulusRNA-Seq of rat myocardial slices cultured with biomimetic electromechanical stimulation
Adjusted p-valueLog2-fold change
1.47 × 10-91.5
Emp1'bile duct ligation' vs 'sham'treatmentTranscription profiling of Rattus norvegicus liver cells: sham vs rats after bile duct ligation procedure
Adjusted p-valueLog2-fold change
3.9292 × 10-61.5
Emp1'nitrofurantoin; 10 milligram per kilogram' vs 'none' in 'nitrofurantoin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
8.4553 × 10-61.5
Emp1'hypertension' vs 'normal' in '20 month'age, diseaseTranscription profiling of rat left ventricular samples from 12-, 16- and 20-month old spontaneously hypertensive rats (SHRs) compared with age-matched Wistar-Kyoto (WKY) rats as controls
Adjusted p-valueLog2-fold change
1.1322 × 10-31.5
Emp1'acquired epilepsy (anakinra and VX-765)' vs 'normal'compound, diseaseTranscriptional profiling of rats with acquired epilepsy treated with two antiinflammatory drugs, VX-765 or Anakinra to study the blockade of IL-1β-mediated signaling in status epilepticus
Adjusted p-valueLog2-fold change
5.709 × 10-3-1.5
Emp1'48 hour' vs '0 hour'timeTranscription profiling by array of Rattus norvegicus muscle samples in response to chronic dose of corticosteroids
Adjusted p-valueLog2-fold change
1.9905 × 10-2-1.5
Emp1'phenylbutazone; 200 milligram per kilogram' vs 'none' in 'phenylbutazone; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
3.4917 × 10-21.5
Emp1'ciprofloxacin; 100 milligram per kilogram' vs 'none' in 'ciprofloxacin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
4.7637 × 10-21.5
Emp1'ciprofloxacin; 300 milligram per kilogram' vs 'none' in 'ciprofloxacin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.177 × 10-5-1.4
Emp1'soy diet' vs 'casein control diet'dietTranscription profiling by array of rat colon after soy or wheat diet
Adjusted p-valueLog2-fold change
8.2419 × 10-51.4
Emp1'monocrotaline; 30 milligram per kilogram' vs 'none' in 'monocrotaline; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
1.2307 × 10-2-1.4
Emp1'phenylbutazone; 60 milligram per kilogram' vs 'none' in 'phenylbutazone; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
1.4713 × 10-21.4
Emp1'Streptococcus pneumoniae' vs 'control' in 'hippocampus' at '1 day'infect, organism part, timeTranscription profiling of rat hippocampus and cortex in the time series of Pneumococcal Meningitis infection
Adjusted p-valueLog2-fold change
2.1229 × 10-21.4
Emp1'lomustine; 6 milligram per kilogram' vs 'none' in 'lomustine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
3.4422 × 10-91.3
Emp1'gentamicin; 10 milligram per kilogram' vs 'none' in 'gentamicin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
1.2237 × 10-5-1.3
Emp1'bromoethylamine; 20 milligram per kilogram' vs 'none' in 'bromoethylamine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
6.1116 × 10-4-1.3
Emp1'36 hour' vs '0 hour'timeTranscription profiling by array of Rattus norvegicus muscle samples in response to chronic dose of corticosteroids
Adjusted p-valueLog2-fold change
6.2393 × 10-41.3
Emp1'ANIT; 125 milligram per kilogram' vs 'control; 'compoundExpression data from Rat liver 48 hours after treated with different toxic compounds.
Adjusted p-valueLog2-fold change
8.5935 × 10-41.3
Emp1'allopurinol; 150 milligram per kilogram' vs 'none' in 'allopurinol; kidney' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with A.
Adjusted p-valueLog2-fold change
6.4753 × 10-31.3
Emp1'phenylbutazone; 20 milligram per kilogram' vs 'none' in 'phenylbutazone; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
8.585 × 10-3-1.3
Emp1'experimental colitis' at '2 day' vs 'normal'disease, timeTranscription profiling of rats with colitis induced with trinitrobenzene sulfonate - time series
Adjusted p-valueLog2-fold change
8.585 × 10-3-1.3
Emp1'2 day' vs '0 day'timeTranscription profiling of rat trinitrobencenesulfonic acid (TNBS)-induced colitis model 2, 5, 7 and 14 days after TNBS treatment
Adjusted p-valueLog2-fold change
1.308 × 10-2-1.3
Emp1'streptozotocin; type I diabetes mellitus' vs 'none; normal' in 'Wistar'compound, disease, strainThe role of insulin resistance in experimental diabetic retinopathy - genetic and molecular aspects
Adjusted p-valueLog2-fold change
1.7449 × 10-21.3
Emp1'sciatic nerve transection for neuropathic pain' vs 'sham surgery'treatmentTranscription profiling of dorsal root ganglia from rats with and without traumatic neuropathic pain from sciatic nerve transection to identify genes responsible for mechanical hypersensitivity
Adjusted p-valueLog2-fold change
1.861 × 10-21.3
Emp1'phenylbutazone; 200 milligram per kilogram' vs 'none' in 'phenylbutazone; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
3.5328 × 10-2-1.3
Emp1'thioacetamide; 15 milligram per kilogram' vs 'none' in 'thioacetamide; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
1.9377 × 10-4-1.2
Emp1'amiodarone; 200 milligram per kilogram' vs 'none' in 'amiodarone; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with A.
Adjusted p-valueLog2-fold change
1.6641 × 10-3-1.2
Emp1'experimental colitis' at '5 day' vs 'normal'disease, timeTranscription profiling of rats with colitis induced with trinitrobenzene sulfonate - time series
Adjusted p-valueLog2-fold change
1.6641 × 10-3-1.2
Emp1'5 day' vs '0 day'timeTranscription profiling of rat trinitrobencenesulfonic acid (TNBS)-induced colitis model 2, 5, 7 and 14 days after TNBS treatment
Adjusted p-valueLog2-fold change
2.991 × 10-31.2
Emp1'Streptococcus pneumoniae' vs 'control' in 'cerebral cortex' at '1 day'infect, organism part, timeTranscription profiling of rat hippocampus and cortex in the time series of Pneumococcal Meningitis infection
Adjusted p-valueLog2-fold change
3.8677 × 10-31.2
Emp1'bucetin; 300 milligram per kilogram' vs 'none' in 'bucetin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
1.7905 × 10-2-1.2
Emp1'juvenile calyx, close to the onset of hearing' vs 'calyx of Helds formation'phenotypeExpression profiles of globular bushy cells (GBCs) during maturation
Adjusted p-valueLog2-fold change
2.5854 × 10-2-1.2
Emp1'lomustine; 0.6 milligram per kilogram' vs 'none' in 'lomustine; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
4.7246 × 10-21.2
Emp1'enalapril; 200 milligram per kilogram' vs 'none' in 'enalapril; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
2.4367 × 10-8-1.1
Emp1'distal colon' vs 'proximal colon' in 'saline (control)'compound, organism partGlobal gene expression of the colonic epithelium from proximal and distal sections of azoxymethane and saline-treated Sprague Dawley rats
Adjusted p-valueLog2-fold change
4.3056 × 10-51.1
Emp1'hypertension' vs 'normal' in '16 month'age, diseaseTranscription profiling of rat left ventricular samples from 12-, 16- and 20-month old spontaneously hypertensive rats (SHRs) compared with age-matched Wistar-Kyoto (WKY) rats as controls
Adjusted p-valueLog2-fold change
1.3561 × 10-4-1.1
Emp1'lipopolysaccharide; 0.1 microgram per milliliter' vs 'none'compoundTranscription profiling by array of rat microglia treated with C6 glioma-conditioned medium or lipopolysaccharide
Adjusted p-valueLog2-fold change
1.812 × 10-31.1
Emp1'acquired epilepsy (VX-765)' vs 'normal'compound, diseaseTranscriptional profiling of rats with acquired epilepsy treated with two antiinflammatory drugs, VX-765 or Anakinra to study the blockade of IL-1β-mediated signaling in status epilepticus
Adjusted p-valueLog2-fold change
2.6894 × 10-31.1
Emp1'1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide; 50 milligram per kilogram' at '96 hour' vs 'none'compound, timeTranscription profiling by array of rat testis after treatment with 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide
Adjusted p-valueLog2-fold change
3.9278 × 10-31.1
Emp1'cancer; inoculation of cancer cell' vs 'normal; none'disease, injuryTranscription profiling by of rat bladder after inoculation with bladder cancer cells
Adjusted p-valueLog2-fold change
1.1808 × 10-21.1
Emp1'colchicine; 15 milligram per kilogram' vs 'none' in 'colchicine; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
2.1053 × 10-21.1
Emp1'thioacetamide; 15 milligram per kilogram' vs 'none' in 'thioacetamide; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
2.2923 × 10-2-1.1
Emp1'methyltestosterone; 300 milligram per kilogram' vs 'none' in 'methyltestosterone; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
1.3208 × 10-5-1
Emp1'adult' vs 'neonate'developmental stageTranscription profiling by array of neonatal and adult rat ventricular cardiomyocytes
Adjusted p-valueLog2-fold change
1.8926 × 10-5-1
Emp1'collagen sandwich' at '3 day' vs 'monolayer culture' at '3 day'growth condition, timeGenome-wide gene expression profiles of primary hepatocytes in two different culture systems over an 8-day period
Adjusted p-valueLog2-fold change
2.2756 × 10-51
Emp1'allyl alcohol; 10 milligram per kilogram' vs 'none' in 'allyl alcohol; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
7.9783 × 10-51
Emp1'acetazolamide; 600 milligram per kilogram' vs 'none' in 'acetazolamide; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
2.1288 × 10-4-1
Emp1'dantrolene; 250 milligram per kilogram' vs 'none' in 'dantrolene; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
2.078 × 10-3-1
Emp1'terbinafine; 750 milligram per kilogram' vs 'none' in 'terbinafine; liver' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
2.5889 × 10-3-1
Emp1'terbinafine; 750 milligram per kilogram' vs 'none' in 'terbinafine; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
3.0079 × 10-31
Emp1'monocrotaline; 10 milligram per kilogram' vs 'none' in 'monocrotaline; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
1.0192 × 10-2-1
Emp1'female duodenum' vs 'male duodenum'organism part, sexIdentification of sexually dimorphically expressed genes in rat tissues
Adjusted p-valueLog2-fold change
2.0498 × 10-2-1
Emp1'TNFa and IL1b' vs 'none'stimulusPro-inflammatory cytokines drive functional deregulation of potassium channels in primary synovial fibroblasts
Adjusted p-valueLog2-fold change
2.2287 × 10-2-1
Emp1'cyclosporine A; 100 milligram per kilogram' vs 'none' in 'cyclosporine A; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.