ENSRNOG00000023366 (Styxl1)

rattus norvegicus

serine/threonine/tyrosine interacting-like 1

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Rattus norvegicus
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Showing 12 experiments:
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
5.12 × 10-51.9
Styxl1'methapyrilene; 100 milligram per kilogram' vs 'none' in 'methapyrilene; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
8.3391 × 10-61.8
Styxl1'methapyrilene; 100 milligram per kilogram' vs 'none' in 'methapyrilene; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
2.5828 × 10-41.8
Styxl1'terbinafine; 750 milligram per kilogram' vs 'none' in 'terbinafine; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
3.6264 × 10-51.7
Styxl1'methapyrilene; 100 milligram per kilogram' vs 'none' in 'methapyrilene; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
1.2908 × 10-71.3
Styxl1'48 hour' vs '0 hour' in 'hepatocyte'cell type, timeAssessing concordance of drug-induced transcriptional response in rodent liver and cultured hepatocytes
Adjusted p-valueLog2-fold change
3.3797 × 10-7-1.3
Styxl1'ketoconazole; 10 milligram per kilogram' vs 'none' in 'ketoconazole; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
1.4226 × 10-131.2
Styxl1'cyclophosphamide; 5 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
3.9762 × 10-61.2
Styxl1'cyclosporine A; 300 milligram per kilogram' vs 'none' in 'cyclosporine A; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
5.5733 × 10-51.2
Styxl1'ethambutol; 1000 milligram per kilogram' vs 'none' in 'ethambutol; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
1.6385 × 10-101.1
Styxl1'hexachlorobenzene; 300 milligram per kilogram' vs 'none' in 'hexachlorobenzene; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
3.3695 × 10-71.1
Styxl1'caffeine; 10 milligram per kilogram' vs 'none' in 'caffeine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
4.053 × 10-7-1.1
Styxl1'acetazolamide; 60 milligram per kilogram' vs 'none' in 'acetazolamide; kidney' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
1.0025 × 10-6-1.1
Styxl1'cyclophosphamide; 150 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
4.7431 × 10-51.1
Styxl1'caffeine; 100 milligram per kilogram' vs 'none' in 'caffeine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
5.5669 × 10-5-1.1
Styxl1'omeprazole; 100 milligram per kilogram' vs 'none' in 'omeprazole; kidney' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
2.122 × 10-41.1
Styxl1'imipramine; 30 milligram per kilogram' vs 'none' in 'imipramine; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
1.2061 × 10-21.1
Styxl1'propylthiouracil; 100 milligram per kilogram' vs 'none' in 'propylthiouracil; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
7.9956 × 10-91
Styxl1'fenofibrate; 100 milligram per kilogram' vs 'none' in 'fenofibrate; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
3.6019 × 10-8-1
Styxl1'cyclophosphamide; 50 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.7018 × 10-6-1
Styxl1'erythromycin ethylsuccinate; 1000 milligram per kilogram' vs 'none' in 'erythromycin ethylsuccinate; kidney' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
3.5088 × 10-5-1
Styxl1'cyclophosphamide; 150 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
3.817 × 10-41
Styxl1'ethambutol; 300 milligram per kilogram' vs 'none' in 'ethambutol; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
6.453 × 10-4-1
Styxl1'indomethacin; 50 milligram per kilogram' vs 'none' in 'indomethacin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
1.0006 × 10-31
Styxl1'disulfiram; 600 milligram per kilogram' vs 'none' in 'disulfiram; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
1.1141 × 10-31
Styxl1'ticlopidine; 300 milligram per kilogram' vs 'none' in 'ticlopidine; liver' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
1.858 × 10-31
Styxl1'thioacetamide; 45 milligram per kilogram' vs 'none' in 'thioacetamide; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
2.6371 × 10-31
Styxl1'propylthiouracil; 10 milligram per kilogram' vs 'none' in 'propylthiouracil; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
3.4382 × 10-31
Styxl1'WY-14643; 30 milligram per kilogram' vs 'none' in 'WY-14643; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with U to Z.
Adjusted p-valueLog2-fold change
8.4894 × 10-31
Styxl1'WY-14643; 30 milligram per kilogram' vs 'none' in 'WY-14643; liver' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with U to Z.
Adjusted p-valueLog2-fold change
1.3001 × 10-21
Styxl1'terbinafine; 750 milligram per kilogram' vs 'none' in 'terbinafine; liver' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with S to T.