FBgn0052082 (IRSp53)

drosophila melanogaster

Insulin receptor substrate 53 kDa

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Drosophila melanogaster
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Showing 4 experiments:
Created with Highcharts 6.2.0adult CCAP neuronalpha’/beta’ middle Kenyon cellcentrifugal neuron C3distal medullary amacrine neuron Dm10distal medullary amacrine neuron Dm9dopaminergic PAM neuron 6gamma dorsal Kenyon celllamina monopolar neuron L2lobula columnar neuron LC10alobula columnar neuron LC6lobula-lobula plate columnar neuron LLPC1mushroom body output neuronproximal medullary amacrine neuron Pm3transmedullary neuron Tm1transmedullary neuron Tm4adult lamina marginal glial cellalpha/beta posterior Kenyon cellcolumnar neuron T1distal medullary amacrine neuron Dm3dopaminergic PAM neuron 3dopaminergic PAM neuron 9lamina intrinsic neuronlamina monopolar neuron L5lobula columnar neuron LC10dlobula plate tangential neuronmedullary intrinsic neuron Mi4photoreceptor cell R7T neurontransmedullary neuron Tm29
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Davis et al., 2020 - cell types - head
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Davis et al., 2020 - cell types - …
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-2.9
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
1.6408 × 10-7-2.9
IRSp53'fas P218 mutation' vs 'wild type genotype'genotypeRNA-seq of Drosophila embryos with P218 mutation in the faint sausage (fas) gene against wild-type controls to study the role fo fas in pre-mRNA splicing during embryogenesis
Adjusted p-valueLog2-fold change
4.7209 × 10-302
IRSp53'bam-Gal4/w1118;Sp/P{KK102965}VIE-260B;bam-Gal4:VP16/+; dLSD1 knockdown by siRNA' vs 'P{KK102965}VIE-260B; wild type phenotype'genotype, phenotypeRNA-seq of Drosophila melanogaster testes upon knock-down of dCoREST, dLSD1 and controls
Adjusted p-valueLog2-fold change
5.1956 × 10-111.9
IRSp53'dCoREST knockdown by siRNA' vs 'EGFP knockdown by siRNA'RNA interferenceRNA-seq of D. melanogaster S2 cells upon depletion of dCoREST and its interacting partners compared to control
Adjusted p-valueLog2-fold change
1.5901 × 10-31.6
IRSp53'dL(3)mbt knockdown by siRNA' vs 'EGFP knockdown by siRNA'RNA interferenceRNA-seq of D. melanogaster S2 cells upon depletion of dCoREST and its interacting partners compared to control
Adjusted p-valueLog2-fold change
1.0355 × 10-41.5
IRSp53'w-;lgl4.FRT40A/CyO.Actin–GFP, 228 hour AEL' vs 'wild type, 108 hour AEL'genotype, timeTime Series gene expression profiling of Lethal Giant Larvae tumours in developing wings of Drosophila larvae
Adjusted p-valueLog2-fold change
3.7908 × 10-41.4
IRSp53'w-;lgl4.FRT40A/CyO.Actin–GFP, 252 hour AEL' vs 'wild type, 108 hour AEL'genotype, timeTime Series gene expression profiling of Lethal Giant Larvae tumours in developing wings of Drosophila larvae
Adjusted p-valueLog2-fold change
5.7995 × 10-51.3
IRSp53'w-;lgl4.FRT40A/CyO.Actin–GFP, 204 hour AEL' vs 'wild type, 108 hour AEL'genotype, timeTime Series gene expression profiling of Lethal Giant Larvae tumours in developing wings of Drosophila larvae
Adjusted p-valueLog2-fold change
5.1108 × 10-41.2
IRSp53'lethal giant larvae null mutant' vs 'wild type'genotypeTranscription profiling by array of neoplastically transformed lgl mosaic wing imaginal disc epithelium of Drosophila melanogaster
Adjusted p-valueLog2-fold change
2.3112 × 10-31.2
IRSp53'Ets21C overexpression' vs 'control'genetic modificationTranscriptional profiling of Drosophila neoplastic tumors to identify Ets21C dependent target genes
Adjusted p-valueLog2-fold change
8.2949 × 10-181.1
IRSp53'Max knockout; Myc overepxression' vs 'wild type phenotype'phenotypeMyc-dependent transcriptome of Drosophila L3 larval wing imaginal discs, and its dependency on Max and/or the PAF1 complex component Atu/Leo1
Adjusted p-valueLog2-fold change
1.0432 × 10-81.1
IRSp53'sterigmatocystin' vs 'Aspergillus nidulans wild type' at '24 hour'growth condition, sampling time pointRNA-seq experiment of Drosophila melanogaster larvae reared on Aspergillus nidulans infested breeding substrate
Adjusted p-valueLog2-fold change
7.018 × 10-6-1.1
IRSp53'PolyQ Atro A66QC transgene' at '14 day' vs 'wild type' at '14 day'genotype, timeTranscription profiling by array of Drosophila with temperature-dependent expression of polyQ-expanded Atrophin transgenes
Adjusted p-valueLog2-fold change
8.0918 × 10-51.1
IRSp53'w-;lgl4.FRT40A/CyO.Actin–GFP, 180 hour AEL' vs 'wild type, 108 hour AEL'genotype, timeTime Series gene expression profiling of Lethal Giant Larvae tumours in developing wings of Drosophila larvae
Adjusted p-valueLog2-fold change
6.16 × 10-31.1
IRSp53'daGS;InRDN>FKH-RNAi' vs 'daGS;InRDN>GFP-RNAi' in 'mifepristone; 200 micromolar'compound, genotypeRNA-seq of Drosophila melanogaster gut to investigate the effect FKH shRNA knockdown and reduced insulin signalling activity
Adjusted p-valueLog2-fold change
1.3113 × 10-141
IRSp53'Max knockout' vs 'wild type phenotype'phenotypeMyc-dependent transcriptome of Drosophila L3 larval wing imaginal discs, and its dependency on Max and/or the PAF1 complex component Atu/Leo1
Adjusted p-valueLog2-fold change
5.2784 × 10-41
IRSp53'homozygous for chico mutation' vs 'wild type'genotypeTranscription profiling by array of Drosophila homozygous and heterozygous chico mutants