CHEBI:50130 - monacolin L

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ChEBI Name monacolin L
ChEBI ID CHEBI:50130
Definition A polyketide that is 1-ethyl-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalene in which one of the methyl hydrogens from the ethyl group is replaced by a 4-hydroxy-6-ketopyran-2-yl group.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Kristian Axelsen
Secondary ChEBI IDs CHEBI:79043
Supplier Information
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Roles Classification
Biological Role(s): Aspergillus metabolite
Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus .
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
Related Structures
monacolin L is a Functional Parent of
dihydromonacolin L
Mass : 306.43970
Formula : C19H30O3
14158 		monacolin J
Mass : 320.42320
Formula : C19H28O4
79034 		monacolin L acid
Mass : 322.43910
Formula : C19H30O4
82987
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