trifluoperazine (CHEBI:45951)

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ChEBI Name	trifluoperazine

ChEBI ID	CHEBI:45951

Definition	A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:45949, CHEBI:9709

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Formula

C21H24F3N3S

Net Charge

Average Mass

407.49669

Monoisotopic Mass

407.16430

InChI

InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3

InChIKey

ZEWQUBUPAILYHI-UHFFFAOYSA-N

SMILES

CN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. calmodulin antagonist An antagonist that interferes with the action of the calcium-binding messenger protein calmodulin. EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12). EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor An EC 5.3.3.* (intramolecular oxidase transposing C2C bonds) inhibitor that interferes with the action of a cholestenol Delta-isomerase (EC 5.3.3.5).

Application(s):	dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. phenothiazine antipsychotic drug

ChEBI Ontology
Outgoing	trifluoperazine (CHEBI:45951) has role antiemetic (CHEBI:50919) trifluoperazine (CHEBI:45951) has role calmodulin antagonist (CHEBI:130181) trifluoperazine (CHEBI:45951) has role dopaminergic antagonist (CHEBI:48561) trifluoperazine (CHEBI:45951) has role EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor (CHEBI:77402) trifluoperazine (CHEBI:45951) has role EC 5.3.3.5 (cholestenol Δ-isomerase) inhibitor (CHEBI:86385) trifluoperazine (CHEBI:45951) has role phenothiazine antipsychotic drug (CHEBI:37930) trifluoperazine (CHEBI:45951) is a N-alkylpiperazine (CHEBI:46845) trifluoperazine (CHEBI:45951) is a N-methylpiperazine (CHEBI:46920) trifluoperazine (CHEBI:45951) is a organofluorine compound (CHEBI:37143) trifluoperazine (CHEBI:45951) is a phenothiazines (CHEBI:38093)

Incoming	trifluoperazine dimaleate (CHEBI:32259) has part trifluoperazine (CHEBI:45951) trifluoperazine hydrochloride (CHEBI:9710) has part trifluoperazine (CHEBI:45951)

IUPAC Name

10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine

Synonyms	Sources
10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine	NIST Chemistry WebBook
10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE	PDBeChem
Trifluoperazine	KEGG COMPOUND
trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine	NIST Chemistry WebBook
trifluoroperazine	NIST Chemistry WebBook
trifluperazine	ChemIDplus

Last Modified

22 February 2017

General Comment
2014-07-14	Trifluoperazinecan be found in blood and urine samples of individuals who have taken this drug.