EMD-13453
Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution.
EMD-13453
Single-particle2.58 Å
Deposition: 23/08/2021Map released: 17/11/2021
Last modified: 17/11/2021
Sample Organism:
Homo sapiens,
synthetic construct,
Rattus norvegicus,
Bos taurus,
Lama glama
Sample: Ternary complex of setmelanotide-activated melanocortin 4 receptor with heterotrimeric Gs, further stabilized by addition of nanobody 35
Fitted models: 7piu
Deposition Authors: Heyder NA
,
Schmidt A ,
Kleinau G,
Hilal T ,
Scheerer P
Sample: Ternary complex of setmelanotide-activated melanocortin 4 receptor with heterotrimeric Gs, further stabilized by addition of nanobody 35
Fitted models: 7piu
Deposition Authors: Heyder NA
,
Schmidt A ,
Kleinau G,
Hilal T ,
Scheerer P
Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Heyder NA ,
Kleinau G,
Speck D ,
Schmidt A ,
Paisdzior S ,
Szczepek M,
Bauer B,
Koch A,
Gallandi M,
Kwiatkowski D ,
Burger J ,
Mielke T ,
Beck-Sickinger AG ,
Hildebrand PW,
Spahn CMT,
Hilger D,
Schacherl M ,
Biebermann H ,
Hilal T ,
Kuhnen P ,
Kobilka BK ,
Scheerer P
(2021) Cell Res , 31 , 1176 - 1189
,
Kleinau G,
Speck D ,
Schmidt A ,
Paisdzior S ,
Szczepek M,
Bauer B,
Koch A,
Gallandi M,
Kwiatkowski D ,
Burger J ,
Mielke T ,
Beck-Sickinger AG ,
Hildebrand PW,
Spahn CMT,
Hilger D,
Schacherl M ,
Biebermann H ,
Hilal T ,
Kuhnen P ,
Kobilka BK ,
Scheerer P
(2021) Cell Res , 31 , 1176 - 1189