EMD-14071

Single-particle
2.9 Å
EMD-14071
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Deposition: 20/12/2021
Map released: 13/04/2022
Last modified: 20/04/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-14071
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Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7qn9 summary report (pdf.gz) Map and 7qn9 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 in a pre-open/closed state

EMD-14071

Single-particle
2.9 Å
EMD-14071
3D View Gallery
Deposition: 20/12/2021
Map released: 13/04/2022
Last modified: 20/04/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens
Sample: Human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with histamine and nanobody Nb25
Fitted models: 7qn9

Deposition Authors: Sente A , Desai R, Naydenova K , Malinauskas T , Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW , Chirgadze DY , Miller KW , Aricescu AR
Differential assembly diversifies GABA A receptor structures and signalling.
Sente A , Desai R, Naydenova K , Malinauskas T , Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW , Chirgadze DY , Miller KW , Aricescu AR
(2022) Nature , 604 , 190 - 194
PUBMED: 35355020
DOI: doi:10.1038/s41586-022-04517-3
ISSN: 1476-4687
ASTM: NATUAS