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EMD-15084
cryo-EM structure of thioredoxin glutathione reductase in complex with a non-competitive inhibitor
EMD-15084
Single-particle3.6 Å
Deposition: 01/06/2022Map released: 14/06/2023
Last modified: 13/11/2024
Sample Organism:
Schistosoma mansoni
Sample: TGR in complex with an inhibitor
Fitted models: 8a1r
Deposition Authors: Ardini M
,
Angelucci F ,
Fata F ,
Gabriele F,
Effantin G ,
Ling W,
Williams DL ,
Petukhova VZ,
Petukhov PA
Sample: TGR in complex with an inhibitor
Fitted models: 8a1r
Deposition Authors: Ardini M
,
Angelucci F ,
Fata F ,
Gabriele F,
Effantin G ,
Ling W,
Williams DL ,
Petukhova VZ,
Petukhov PA
Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo.
Petukhova VZ,
Aboagye SY ,
Ardini M ,
Lullo RP ,
Fata F ,
Byrne ME,
Gabriele F,
Martin LM ,
Harding LNM ,
Gone V ,
Dangi B,
Lantvit DD,
Nikolic D,
Ippoliti R ,
Effantin G ,
Ling WL ,
Johnson JJ,
Thatcher GRJ,
Angelucci F ,
Williams DL ,
Petukhov PA
(2023) Nat Commun , 14 , 3737 - 3737
,
Ardini M ,
Lullo RP ,
Fata F ,
Byrne ME,
Gabriele F,
Martin LM ,
Harding LNM ,
Gone V ,
Dangi B,
Lantvit DD,
Nikolic D,
Ippoliti R ,
Effantin G ,
Ling WL ,
Johnson JJ,
Thatcher GRJ,
Angelucci F ,
Williams DL ,
Petukhov PA
(2023) Nat Commun , 14 , 3737 - 3737