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EMD-17172
Ternary structure of intramolecular bivalent glue degrader IBG1 bound to BRD4 and DCAF16:DDB1deltaBPB
EMD-17172
Single-particle3.77 Å
Deposition: 20/04/2023Map released: 17/05/2023
Last modified: 13/03/2024
Sample Organism:
Homo sapiens
Sample: Ternary complex of BRD4 tandem bromodomains, compound 1, DCAF16 and DDB1deltaBPB
Deposition Authors: Cowan AD
,
Sundaramoorthy R ,
Nakasone MA ,
Ciulli A
Sample: Ternary complex of BRD4 tandem bromodomains, compound 1, DCAF16 and DDB1deltaBPB
Deposition Authors: Cowan AD
,
Sundaramoorthy R ,
Nakasone MA ,
Ciulli A
Targeted protein degradation via intramolecular bivalent glues.
Hsia O ,
Hinterndorfer M ,
Cowan AD ,
Iso K ,
Ishida T ,
Sundaramoorthy R ,
Nakasone MA ,
Imrichova H ,
Schatz C,
Rukavina A ,
Husnjak K ,
Wegner M ,
Correa-Saez A ,
Craigon C ,
Casement R,
Maniaci C ,
Testa A ,
Kaulich M ,
Dikic I ,
Winter GE ,
Ciulli A
(2024) Nature , 627 , 204 - 211
,
Hinterndorfer M ,
Cowan AD ,
Iso K ,
Ishida T ,
Sundaramoorthy R ,
Nakasone MA ,
Imrichova H ,
Schatz C,
Rukavina A ,
Husnjak K ,
Wegner M ,
Correa-Saez A ,
Craigon C ,
Casement R,
Maniaci C ,
Testa A ,
Kaulich M ,
Dikic I ,
Winter GE ,
Ciulli A
(2024) Nature , 627 , 204 - 211