EMD-18455

Single-particle
3.2 Å
EMD-18455
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Deposition: 14/09/2023
Map released: 01/11/2023
Last modified: 20/11/2024
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EMD-18455
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Human Adenovirus type 11 fiber knob in complex with its cell receptors, Desmoglein-2 and CD46

EMD-18455

Single-particle
3.2 Å
EMD-18455
3D View Gallery
Deposition: 14/09/2023
Map released: 01/11/2023
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens, Escherichia coli, Human adenovirus 11
Sample: Complex between the human adenovirus 11 fiber knob, the human desmoglein 2 (domains ec2/ec3) and the human CD46 (domains SCR1 and SCR2)
Fitted models: 8qk3 (Avg. Q-score: 0.446)

Deposition Authors: Effantin G
Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.
Effantin G, Hograindleur M-A, Fenel D, Fender P , Vassal-Stermann E
(2023) J Virol , 97 , e0091023 - e0091023
PUBMED: 37921471
DOI: doi:10.1128/jvi.00910-23
ISSN: 1098-5514
ASTM: JOVIAM
Abstract:
Importance
The main limitation of oncolytic vectors is neutralization by blood components, which prevents intratumoral administration to patients. Enadenotucirev, a chimeric HAdV-11p/HAdV-3 adenovirus identified by bio-selection, is a low seroprevalence vector active against a broad range of human carcinoma cell lines. At this stage, there's still some uncertainty about tropism and primary receptor utilization by HAdV-11. However, this information is very important, as it has a direct influence on the effectiveness of HAdV-11-based vectors. The aim of this work is to determine which of the two receptors, DSG2 and CD46, is involved in the attachment of the virus to the host, and what role they play in the early stages of infection.