EMD-22283

Single-particle
3.1 Å
EMD-22283
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Deposition: 07/07/2020
Map released: 18/11/2020
Last modified: 09/12/2020
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-22283
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 6xox summary report (pdf.gz) Map and 6xox FULL report (pdf.gz)
EMICSS annotations (xml)

cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970

EMD-22283

Single-particle
3.1 Å
EMD-22283
3D View Gallery
Deposition: 07/07/2020
Map released: 18/11/2020
Last modified: 09/12/2020
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens, Lama glama, Mus musculus
Sample: Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein and a non-peptide agonist LY3502970
Fitted models: 6xox

Deposition Authors: Sun B, Kobilka BK, Sloop KW, Feng D, Kobilka TS
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.
Kawai T , Sun B, Yoshino H , Feng D, Suzuki Y , Fukazawa M , Nagao S , Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP , Willard FS , Kawabe Y , Kobilka BK , Sloop KW
(2020) PNAS , 117 , 29959 - 29967
PUBMED: 33177239
DOI: doi:10.1073/pnas.2014879117
ISSN: 1091-6490
ASTM: PNASA6