EMD-24628
Cryo-EM structure of SARS-CoV-2 spike in complex with non-neutralizing NTD-directed CV3-13 Fab isolated from convalescent individual
EMD-24628
Single-particle4.18 Å
Deposition: 05/08/2021Map released: 20/04/2022
Last modified: 09/08/2023
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Homo sapiens
Sample: Cryo-EM structure of SARS-CoV-2 spike in complex with non-neutralizing, NTD-directed human antibody CV3-13
Fitted models: 7rq6
Deposition Authors: Chen Y
,
Pozharski E
Sample: Cryo-EM structure of SARS-CoV-2 spike in complex with non-neutralizing, NTD-directed human antibody CV3-13
Fitted models: 7rq6
Deposition Authors: Chen Y
,
Pozharski E
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection.
Beaudoin-Bussieres G,
Chen Y ,
Ullah I,
Prevost J ,
Tolbert WD,
Symmes K,
Ding S,
Benlarbi M ,
Gong SY ,
Tauzin A ,
Gasser R,
Chatterjee D,
Vezina D,
Goyette G,
Richard J ,
Zhou F,
Stamatatos L,
McGuire AT,
Charest H,
Roger M,
Pozharski E,
Kumar P,
Mothes W,
Uchil PD,
Pazgier M ,
Finzi A
(2022) Cell Rep , 38 , 110368 - 110368
,
Ullah I,
Prevost J ,
Tolbert WD,
Symmes K,
Ding S,
Benlarbi M ,
Gong SY ,
Tauzin A ,
Gasser R,
Chatterjee D,
Vezina D,
Goyette G,
Richard J ,
Zhou F,
Stamatatos L,
McGuire AT,
Charest H,
Roger M,
Pozharski E,
Kumar P,
Mothes W,
Uchil PD,
Pazgier M ,
Finzi A
(2022) Cell Rep , 38 , 110368 - 110368