EMD-28777

Single-particle
2.5 Å
EMD-28777
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Deposition: 03/11/2022
Map released: 12/04/2023
Last modified: 12/04/2023
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-28777
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Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8f0q summary report (pdf.gz) Map and 8f0q FULL report (pdf.gz)
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Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310

EMD-28777

Single-particle
2.5 Å
EMD-28777
3D View Gallery
Deposition: 03/11/2022
Map released: 12/04/2023
Last modified: 12/04/2023
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens
Sample: Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310
Fitted models: 8f0q

Deposition Authors: Kschonsak M , Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine D, McKerall SJ, Hackos DH, Deng L, Chen J, Sutherlin D, Dragovich PS, Volgraf M, Wright MR, Payandeh J , Ciferri C , Tellis JC
Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Kschonsak M , Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine DF, McKerrall SJ, Hackos DH, Deng L, Chen J, Li T, Dragovich PS, Volgraf M, Wright MR, Payandeh J , Ciferri C , Tellis JC
(2023) eLife , 12
PUBMED: 36975198
DOI: doi:10.7554/eLife.84151
ISSN: 2050-084X