EMD-0246

Single-particle
4.2 Å
EMD-0246
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Deposition: 14/09/2018
Map released: 21/11/2018
Last modified: 30/03/2022
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Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-0246
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 6hn4 summary report (pdf.gz) Map and 6hn4 FULL report (pdf.gz)
EMICSS annotations (xml)

Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part

EMD-0246

Single-particle
4.2 Å
EMD-0246
3D View Gallery
Deposition: 14/09/2018
Map released: 21/11/2018
Last modified: 30/03/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sample: Leucine zippered human insulin receptor ectodomain (IR-A isoform, "deltabeta" mutant) in complex with insulin and two Fv 83-7 modules : "lower" membrane-proximal part
Fitted models: 6hn4

Deposition Authors: Weis F , Menting JG , Margetts MB, Chan SJ, Xu Y, Tennagels N, Wohlfart P , Langer T , Mueller CW, Dreyer MK , Lawrence MC
The signalling conformation of the insulin receptor ectodomain.
Weis F , Menting JG , Margetts MB, Chan SJ, Xu Y, Tennagels N, Wohlfart P , Langer T , Muller CW , Dreyer MK , Lawrence MC
(2018) Nat Commun , 9 , 4420 - 4420
PUBMED: 30356040
DOI: doi:10.1038/s41467-018-06826-6
ISSN: 2041-1723