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EMD-21688
Structure of human TRPA1 in complex with inhibitor GDC-0334
EMD-21688
Single-particle3.6 Å
Deposition: 11/04/2020Map released: 17/02/2021
Last modified: 29/05/2024
Sample Organism:
Homo sapiens
Sample: TRPA1 bound by inhibitor GDC-0334
Fitted models: 6wj5
Deposition Authors: Rohou A, Rouge L, Arthur CP
Sample: TRPA1 bound by inhibitor GDC-0334
Fitted models: 6wj5
Deposition Authors: Rohou A, Rouge L, Arthur CP
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
Balestrini A,
Joseph V,
Dourado M,
Reese RM 
,
Shields SD,
Rouge L,
Bravo DD ,
Chernov-Rogan T,
Austin CD,
Chen H,
Wang L,
Villemure E,
Shore DGM,
Verma VA,
Hu B,
Chen Y,
Leong L,
Bjornson C,
Hotzel K,
Gogineni A,
Lee WP,
Suto E,
Wu X,
Liu J,
Zhang J,
Gandham V,
Wang J,
Payandeh J,
Ciferri C,
Estevez A ,
Arthur CP,
Kortmann J,
Wong RL ,
Heredia JE,
Doerr J,
Jung M,
Vander Heiden JA,
Roose-Girma M,
Tam L,
Barck KH,
Carano RAD,
Ding HT,
Brillantes B,
Tam C,
Yang X,
Gao SS,
Ly JQ,
Liu L,
Chen L,
Liederer BM,
Lin JH,
Magnuson S,
Chen J,
Hackos DH,
Elstrott J,
Rohou A,
Safina BS,
Volgraf M,
Bauer RN,
Riol-Blanco L
(2021) J Exp Med , 218
,
Shields SD,
Rouge L,
Bravo DD ,
Chernov-Rogan T,
Austin CD,
Chen H,
Wang L,
Villemure E,
Shore DGM,
Verma VA,
Hu B,
Chen Y,
Leong L,
Bjornson C,
Hotzel K,
Gogineni A,
Lee WP,
Suto E,
Wu X,
Liu J,
Zhang J,
Gandham V,
Wang J,
Payandeh J,
Ciferri C,
Estevez A ,
Arthur CP,
Kortmann J,
Wong RL ,
Heredia JE,
Doerr J,
Jung M,
Vander Heiden JA,
Roose-Girma M,
Tam L,
Barck KH,
Carano RAD,
Ding HT,
Brillantes B,
Tam C,
Yang X,
Gao SS,
Ly JQ,
Liu L,
Chen L,
Liederer BM,
Lin JH,
Magnuson S,
Chen J,
Hackos DH,
Elstrott J,
Rohou A,
Safina BS,
Volgraf M,
Bauer RN,
Riol-Blanco L
(2021) J Exp Med , 218