EMD-23609

Single-particle
2.39 Å
EMD-23609
3D View Gallery
Deposition: 10/03/2021
Map released: 17/03/2021
Last modified: 25/08/2021
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-23609
Download
3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7m05 summary report (pdf.gz) Map and 7m05 FULL report (pdf.gz)
EMICSS annotations (xml)

PRMT5 bound to covalent PBM-site inhibitor BRD-6988

EMD-23609

Single-particle
2.39 Å
EMD-23609
3D View Gallery
Deposition: 10/03/2021
Map released: 17/03/2021
Last modified: 25/08/2021
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens
Sample: Hetero-octamer complex of PRMT5 and WDR77
Fitted models: 7m05

Deposition Authors: McMillan BJ, McKinney DC, Timm DE
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
McKinney DC , McMillan BJ, Ranaghan MJ , Moroco JA , Brousseau M, Mullin-Bernstein Z , O'Keefe M, McCarren P, Mesleh MF, Mulvaney KM, Robinson F, Singh R, Bajrami B, Wagner FF, Hilgraf R, Drysdale MJ, Campbell AJ, Skepner A, Timm DE, Porter D, Kaushik VK, Sellers WR , Ianari A
(2021) J. Med. Chem. , 64 , 11148 - 11168
PUBMED: 34342224
DOI: doi:10.1021/acs.jmedchem.1c00507
ISSN: 0022-2623
ASTM: JMCMAR